{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:44:16Z","timestamp":1793659456802,"version":"4.5.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":45,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2020-02021"],"award-info":[{"award-number":["2020-02021"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006736","name":"\u00d6rebro University Hospital research foundation","doi-asserted-by":"crossref","award":["OLL-890291"],"award-info":[{"award-number":["OLL-890291"]}],"id":[{"id":"10.13039\/501100006736","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004785","name":"NordForsk","doi-asserted-by":"publisher","award":["90569"],"award-info":[{"award-number":["90569"]}],"id":[{"id":"10.13039\/501100004785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The diagnostic and prognostic properties of anti-integrin \u03b1v\u03b26 immunoglobulin G (IgG) autoantibodies in ulcerative colitis (UC) are poorly understood. We aimed to assess the diagnostic performance of anti-integrin \u03b1v\u03b26 autoantibodies and examine their association with disease outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum samples from a Swedish inception cohort of patients with suspected inflammatory bowel disease (IBD, n\u2005=\u2005473) were analyzed using an in-house fluorescence enzyme immunoassay based on EliA technology. Findings were validated in a Norwegian population-based inception cohort (n\u2005=\u2005570). Diagnostic performance was assessed by calculating the area under the curve (AUC) with 95% confidence intervals and determining sensitivity and specificity. Reclassification was evaluated using the net reclassification index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the discovery cohort, patients with UC, IBD-unclassified, or colonic Crohn\u2019s disease exhibited higher median autoantibody levels compared to symptomatic and healthy controls. In the validation cohort, the autoantibody demonstrated 79% sensitivity and 94% specificity for UC vs symptomatic controls at a cut-off of 400 UA\/l. Its diagnostic performance (AUC\u2005=\u20050.92, 95% CI, 0.89-0.95) was superior to hs-CRP (AUC\u2005=\u20050.65, 95% CI, 0.60-0.70, P\u2005&amp;lt;\u2005.001) and faecal calprotectin (fcalpro) (AUC\u2005=\u20050.88, 95% CI, 0.84-0.92, P\u2005=\u2005.09). Combining the autoantibody with fcalpro further improved diagnostic accuracy (AUC\u2005=\u20050.97, 95% CI, 0.95-0.98) and patient reclassification (P\u2005&amp;lt;\u2005.001). Autoantibody positivity was associated with a severe phenotype of UC, characterised by increased inflammatory activity and higher IL-17A and granzyme B levels. Higher autoantibody levels were linked to an aggressive disease course, remaining stable in aggressive UC but decreasing in indolent disease (P\u2005=\u2005.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anti-integrin \u03b1v\u03b26 is a reliable diagnostic and prognostic marker for UC, with potential clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaf062","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T05:44:34Z","timestamp":1744868674000},"source":"Crossref","is-referenced-by-count":14,"title":["Anti-integrin \u03b1v\u03b26 IgG antibody as a diagnostic and prognostic marker in ulcerative colitis: A cross-sectional and longitudinal study defining a specific disease phenotype"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8492-4045","authenticated-orcid":false,"given":"Eleftheria","family":"Pertsinidou","sequence":"first","affiliation":[{"name":"Department of Immunology, Genetics, and Pathology, Uppsala University , Uppsala,","place":["Sweden"]},{"name":"Thermo Fisher Scientific , Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8951-9839","authenticated-orcid":false,"given":"Benita","family":"Salomon","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health, \u00d6rebro University , \u00d6rebro,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1906-0746","authenticated-orcid":false,"given":"Daniel","family":"Bergemalm","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine and Health, \u00d6rebro University , \u00d6rebro,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-4196","authenticated-orcid":false,"given":"Samira","family":"Salihovic","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health, \u00d6rebro University , \u00d6rebro,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-8516","authenticated-orcid":false,"given":"Charlotte R H","family":"Hedin","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna, Karolinska Institutet , Stockholm,","place":["Sweden"]},{"name":"Department of Gastroenterology, Dermatovenereology and Rheumatology, Centre for Digestive Health, Karolinska University Hospital , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5518-7990","authenticated-orcid":false,"given":"Maria","family":"Ling Lundstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences: Gastroenterology and Hepatology, Uppsala University , Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6820-0215","authenticated-orcid":false,"given":"\u00c5sa V","family":"Keita","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, Link\u00f6ping University , Link\u00f6ping,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8888-4968","authenticated-orcid":false,"given":"Maria K","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-383X","authenticated-orcid":false,"given":"Carl","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine and Health, \u00d6rebro University , \u00d6rebro,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-7141","authenticated-orcid":false,"given":"May-Bente","family":"Bengtson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Vestfold Hospital Trust , T\u00f8nsberg,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-1659","authenticated-orcid":false,"given":"Olle","family":"Gr\u00e4nn\u00f6","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, 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