{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:55:52Z","timestamp":1793890552013,"version":"4.8.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with inflammatory bowel disease (IBD), comprising Crohn\u2019s disease (CD) and ulcerative colitis (UC). This study aimed to assess the prevalence and clinical characteristics of HS in a population-based cohort of newly diagnosed IBD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Copenhagen IBD Inception Cohort is a population-based inception cohort of newly diagnosed patients with IBD between May 2021 and April 2023. Inflammatory bowel disease-related clinical data and extraintestinal manifestations (EIMs) were collected, with HS identified through validated self-reported questionnaires and dermatological examinations. Statistical comparisons were performed between IBD patients with and without HS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 527 patients with new-onset IBD, 38.1%, 58.4%, and 3.4% had CD, UC, or unclassified IBD, respectively. Hidradenitis suppurativa was prevalent in 5.5% (n \u2005=\u200529), 8% (n\u2005=\u200516), and 3.9% (n\u2005=\u200512) of patients with CD and UC, respectively. Patients with concomitant HS were most frequently affected in the groin area and buttocks, had significantly higher body mass index (BMI) (26.4 vs 24.2\u00a0kg\/m\u00b2, P\u2005=\u2005.036), and had higher prevalence of EIMs (79.3% vs 41.2%, P\u2005&amp;lt;\u2005.001) compared to patients with IBD alone. Among CD patients, those with HS had higher disease activity (Harvey-Bradshaw Index: 9.6 vs 6.8, P\u2005=\u2005.029) and more frequent perianal disease (31.3% vs 9.7%, P\u2005=\u2005.023).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa is a prevalent comorbidity in newly diagnosed IBD patients. Concomitant HS is associated with increased BMI, a higher burden of EIMs, and greater disease severity. Early dermatological assessment and integrated management strategies are essential to optimize care for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaf066","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T17:21:39Z","timestamp":1744478499000},"source":"Crossref","is-referenced-by-count":7,"title":["Hidradenitis suppurativa among patients with new-onset inflammatory bowel disease\u2014results from the IBD Prognosis Study"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7395-6009","authenticated-orcid":false,"given":"Valdemar Wendelboe","family":"Nielsen","sequence":"first","affiliation":[{"name":"Department of Dermato-Venereology & Wound Healing Centre, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0323-7030","authenticated-orcid":false,"given":"Mohamed","family":"Attauabi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Copenhagen University Hospital\u2014Herlev and Gentofte , Herlev ,","place":["Denmark"]},{"name":"Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents, and Adults, Copenhagen University Hospital\u2014Amager and Hvidovre , Hvidovre ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4616-5188","authenticated-orcid":false,"given":"Nikolaj","family":"Holgersen","sequence":"additional","affiliation":[{"name":"Department of Dermato-Venereology & Wound Healing Centre, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-7338","authenticated-orcid":false,"given":"Gorm Roager","family":"Madsen","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents, and Adults, Copenhagen University Hospital\u2014Amager and Hvidovre , Hvidovre ,","place":["Denmark"]},{"name":"Gastrounit, Medical Division, Copenhagen University Hospital\u2014Amager and Hvidovre , Hvidovre ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents, and Adults, Copenhagen University Hospital\u2014Amager and Hvidovre , Hvidovre ,","place":["Denmark"]},{"name":"Gastrounit, Medical Division, Copenhagen University Hospital\u2014Amager and Hvidovre , Hvidovre ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3230-7966","authenticated-orcid":false,"given":"Jakob","family":"Seidelin","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Digestive Diseases, Transplantation and General Surgery, Section for IBD, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-300X","authenticated-orcid":false,"given":"Simon Francis","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Dermato-Venereology & Wound Healing Centre, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Copenhagen ,","place":["Denmark"]},{"name":"Department of Biomedical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-5139","authenticated-orcid":false,"given":"Johan","family":"Burisch","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents, and Adults, Copenhagen University Hospital\u2014Amager and Hvidovre , Hvidovre ,","place":["Denmark"]},{"name":"Gastrounit, Medical Division, Copenhagen University Hospital\u2014Amager and Hvidovre , Hvidovre ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,19]]},"reference":[{"key":"2025060311002562500_CIT0001","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1365-2133.2009.09430.x","article-title":"Hidradenitis suppurativa and inflammatory bowel disease: are they associated? Results of a pilot study","volume":"162","author":"Van Der Zee","year":"2010","journal-title":"Br J Dermatol."},{"key":"2025060311002562500_CIT0002","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1111\/bjd.13002","article-title":"The prevalence of hidradenitis suppurativa in 1093 patients with inflammatory bowel disease","volume":"171","author":"Van Der Zee","year":"2014","journal-title":"Br J Dermatol."},{"key":"2025060311002562500_CIT0003","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1159\/000431175","article-title":"Hidradenitis suppurativa\/acne inversa: criteria for diagnosis, severity assessment, classification and disease evaluation","volume":"231","author":"Zouboulis","year":"2015","journal-title":"Dermatology."},{"key":"2025060311002562500_CIT0004","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/ijd.17498","article-title":"Differentiating clinical characteristics of perianal inflammatory bowel disease from perianal hidradenitis suppurativa","volume":"64","author":"Yamanaka-Takaichi","year":"2025","journal-title":"Int J Dermatol."},{"key":"2025060311002562500_CIT0005","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1001\/jamadermatol.2021.1677","article-title":"Prevalence of hidradenitis suppurativa: a systematic review and meta-regression analysis","volume":"157","author":"Jfri","year":"2021","journal-title":"JAMA Dermatology"},{"key":"2025060311002562500_CIT0006","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1111\/jdv.20472","article-title":"European S2k guidelines for hidradenitis suppurativa\/acne inversa part 2: treatment","volume":"39","author":"Zouboulis","year":"2025","journal-title":"J Eur Acad Dermatology Venereol."},{"key":"2025060311002562500_CIT0007","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1111\/jdv.12966","article-title":"European S1 guideline for the treatment of hidradenitis suppurativa\/acne inversa","volume":"29","author":"Zouboulis","year":"2015","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"2025060311002562500_CIT0008","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jaad.2019.02.068","article-title":"North American clinical management guidelines for hidradenitis suppurativa: a publication from the United States and Canadian Hidradenitis Suppurativa Foundations","volume":"81","author":"Alikhan","year":"2019","journal-title":"J Am Acad Dermatol."},{"key":"2025060311002562500_CIT0009","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1001\/jamadermatol.2019.0891","article-title":"Association of hidradenitis suppurativa with inflammatory bowel disease","volume":"155","author":"Chen","year":"2019","journal-title":"JAMA Dermatol"},{"key":"2025060311002562500_CIT0010","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1001\/jamadermatol.2023.2217","article-title":"Genetic variants associated with hidradenitis suppurativa","volume":"159","author":"Sun","year":"2023","journal-title":"JAMA Dermatol"},{"key":"2025060311002562500_CIT0011","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2023.1071616","article-title":"Causal association between inflammatory bowel disease and hidradenitis suppurativa: a two-sample bidirectional Mendelian randomization study","volume":"14","author":"Bao","year":"2023","journal-title":"Front Immunol."},{"key":"2025060311002562500_CIT0012","doi-asserted-by":"publisher","first-page":"601","DOI":"10.2340\/00015555-0749","article-title":"Increased serum tumour necrosis factor-alpha in hidradenitis suppurativa patients: is there a basis for treatment with anti-tumour necrosis factor-alpha agents","volume":"89","author":"Matusiak","year":"2009","journal-title":"Acta Derm Venereol."},{"key":"2025060311002562500_CIT0013","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nri3661","article-title":"Cytokines in inflammatory bowel disease","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat Rev Immunol."},{"key":"2025060311002562500_CIT0014","doi-asserted-by":"publisher","first-page":"e055779","DOI":"10.1136\/bmjopen-2021-055779","article-title":"Influence of genetics, immunity and the microbiome on the prognosis of inflammatory bowel disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study","volume":"12","author":"Attauabi","year":"2022","journal-title":"BMJ Open"},{"key":"2025060311002562500_CIT0015","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae176","article-title":"Incidence, disease burden and clinical presentation of patients newly diagnosed with inflammatory bowel disease in a population-based inception cohort","author":"Attauabi","year":"2024","journal-title":"J Crohns Colitis."},{"key":"2025060311002562500_CIT0016","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1111\/bjd.12787","article-title":"The prevalence of inverse recurrent suppuration: a population-based study of possible hidradenitis suppurativa","volume":"170","author":"Vinding","year":"2014","journal-title":"Br J Dermatol."},{"key":"2025060311002562500_CIT0017","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1056\/NEJMcp1014163","article-title":"Hidradenitis suppurativa","volume":"366","author":"Jemec","year":"2012","journal-title":"N Engl J Med."},{"key":"2025060311002562500_CIT0018","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1111\/bjd.15748","article-title":"Development and validation of the International Hidradenitis Suppurativa Severity Score System (IHS4), a novel dynamic scoring system to assess HS severity","volume":"177","author":"Zouboulis","year":"2017","journal-title":"Br J Dermatol."},{"key":"2025060311002562500_CIT0019","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1093\/ibd\/izaa167","article-title":"Systematic review with meta-analysis: the impact of co-occurring immune-mediated inflammatory diseases on the disease course of inflammatory bowel diseases","volume":"27","author":"Attauabi","year":"2021","journal-title":"Inflamm Bowel Dis."},{"key":"2025060311002562500_CIT0020","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1016\/j.cgh.2019.03.040","article-title":"Incidence of immune-mediated inflammatory diseases among patients with inflammatory bowel diseases in Denmark","volume":"17","author":"Burisch","year":"2019","journal-title":"Clin Gastroenterol Hepatol."},{"key":"2025060311002562500_CIT0021","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1097\/MIB.0000000000000579","article-title":"Identification of clinical and genetic parameters associated with hidradenitis suppurativa in inflammatory bowel disease","volume":"22","author":"Janse","year":"2016","journal-title":"Inflamm Bowel Dis."},{"key":"2025060311002562500_CIT0022","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s10620-018-4919-5","article-title":"Risk factors for hidradenitis suppurativa in patients with inflammatory bowel disease","volume":"63","author":"Lukach","year":"2018","journal-title":"Dig Dis Sci."},{"key":"2025060311002562500_CIT0023","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/ijd.13932","article-title":"The in-hospital burden of hidradenitis suppurativa in patients with inflammatory bowel disease: a decade nationwide analysis from 2004 to 2014","volume":"57","author":"Ramos-Rodriguez","year":"2018","journal-title":"Int J Dermatol."},{"key":"2025060311002562500_CIT0024","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/jcag\/gwaa024","article-title":"Risk factors for developing hidradenitis suppurativa in patients with inflammatory bowel disease: a retrospective case\u2013control study","volume":"4","author":"Tandon","year":"2021","journal-title":"J. Can. Assoc. Gastroenterol."},{"key":"2025060311002562500_CIT0025","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.jaad.2016.12.015","article-title":"Disease modification for hidradenitis suppurativa: a new paradigm","volume":"76","author":"Paek","year":"2017","journal-title":"J Am Acad Dermatol."},{"key":"2025060311002562500_CIT0026","doi-asserted-by":"publisher","first-page":"e321","DOI":"10.1111\/ijd.16628","article-title":"Characteristics of patients with hidradenitis suppurativa and concomitant inflammatory bowel disease","volume":"62","author":"Nielsen","year":"2023","journal-title":"Int J Dermatol."},{"key":"2025060311002562500_CIT0027","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1159\/000541612","article-title":"The Copenhagen hidradenitis suppurativa cohort: insights from the first 8 years","volume":"240","author":"Holgersen","year":"2024","journal-title":"Dermatology."},{"key":"2025060311002562500_CIT0028","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.3390\/jcm10061311","article-title":"The temporal relationships and associations between cutaneous manifestations and inflammatory bowel disease: a nationwide population-based cohort study","volume":"10","author":"Hung","year":"2021","journal-title":"J Clin Med"},{"key":"2025060311002562500_CIT0029","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/apt.15863","article-title":"Increased risk of permanent stoma in Crohn\u2019s disease associated with hidradenitis suppurativa: a case-control study","volume":"52","author":"Dumont","year":"2020","journal-title":"Aliment Pharmacol Ther."},{"key":"2025060311002562500_CIT0030","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1056\/NEJMoa1504370","article-title":"Two phase 3 trials of adalimumab for hidradenitis suppurativa","volume":"375","author":"Kimball","year":"2016","journal-title":"N Engl J Med."},{"key":"2025060311002562500_CIT0031","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1053\/j.gastro.2005.11.030","article-title":"Human anti\u2013tumor necrosis factor monoclonal antibody (Adalimumab) in Crohn\u2019s disease: the CLASSIC-I Trial","volume":"130","author":"Hanauer","year":"2006","journal-title":"Gastroenterology."},{"key":"2025060311002562500_CIT0032","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1053\/j.gastro.2011.10.032","article-title":"Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis","volume":"142","author":"Sandborn","year":"2012","journal-title":"Gastroenterology."},{"key":"2025060311002562500_CIT0033","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/jvc2.89","article-title":"Cluster analysis identifies six clinical subtypes of hidradenitis suppurativa characterised by distinct comorbidities, inflammatory and metabolic profiles, patient-reported outcomes and treatment patterns","volume":"2","author":"J\u00f8rgensen","year":"2023","journal-title":"JEADV Clin Pract"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/advance-article-pdf\/doi\/10.1093\/ecco-jcc\/jjaf066\/62956239\/jjaf066.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/5\/jjaf066\/62956239\/jjaf066.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/5\/jjaf066\/62956239\/jjaf066.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T11:01:43Z","timestamp":1748948503000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/doi\/10.1093\/ecco-jcc\/jjaf066\/8116398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,19]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,8]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjaf066","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,4,19]]},"article-number":"jjaf066"}}