{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:10:58Z","timestamp":1781755858371,"version":"3.54.5"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Kitasato University Kitasato Institute Hospital, Tokyo, Japan","award":["18015"],"award-info":[{"award-number":["18015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Intestinal ultrasound (IUS) is a valuable tool for assessing short-term responses to treatment of ulcerative colitis (UC). Nevertheless, no prior reports on IUS use, earlier than weeks 6\u201314, are known for predicting long-term endoscopic responses. This study evaluated whether IUS (transabdominal and transperineal) at week 1 can predict long-term clinical\u2013endoscopic remission (CER) and histo-endoscopic mucosal improvement (HEMI) following advanced therapies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a post-hoc analysis of a prospective study examining the predictive value of IUS at baseline and weeks 1 and 8 after the initiation of advanced therapy in patients with active UC. CER and HEMI were defined based on the Mayo endoscopic subscore and Geboes score assessed from colonoscopy after &amp;gt;14\u2009weeks. The predictive values of the IUS for CER and HEMI were assessed using a receiver operating characteristic analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 69 patients, 15 (21%) achieved CER and 11 (16%) achieved HEMI. At week 1, reduction in rectal bowel wall thickness (\u0394rectal BWT) was significantly greater in the CER and HEMI groups than those without these improvements (CER: 1.1\u2009\u00b1\u20090.7 vs \u22120.1\u2009\u00b1\u20091.4, P\u2009&amp;lt;\u2009.01; HEMI: 1.2\u2009\u00b1\u20090.7 vs 0.0\u2009\u00b1\u20091.4, P\u2009&amp;lt;\u2009.01). However, \u0394rectal BWT at week 8 did not differ between the groups. \u0394Rectal BWT at week 1 accurately predicted both CER [area under the curve (AUC) 0.75; 95% CI 0.60\u20130.86; P\u2009=\u2009.02] and HEMI (AUC 0.79; 95% CI 0.65\u20130.88; P\u2009=\u2009.02) with high accuracy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Assessing rectal wall thickness at week 1 is valuable for predicting advanced therapy-induced CER and HEMI in patients with UC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registry Number<\/jats:title>\n                  <jats:p>UMIN000032422 (https:\/\/upload.umin.ac.jp\/cgi-open-bin\/ctr_e\/ctr_view.cgi? recptno=R000036970).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaf141","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T17:15:13Z","timestamp":1755018913000},"source":"Crossref","is-referenced-by-count":5,"title":["Early reduction in rectal wall thickness on transperineal ultrasound predicts mucosal healing in ulcerative colitis"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-8161","authenticated-orcid":false,"given":"Shintaro","family":"Sagami","sequence":"first","affiliation":[{"name":"Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Odajima","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Kitasato University Kitasato Institute Hospital , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Asonoma","sequence":"additional","affiliation":[{"name":"Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital , Tokyo,","place":["Japan"]},{"name":"Department of Gastroenterology and Hepatology, Kitasato University Kitasato Institute Hospital , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Miyatani","sequence":"additional","affiliation":[{"name":"Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Nakano","sequence":"additional","affiliation":[{"name":"Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital , Tokyo,","place":["Japan"]},{"name":"Department of Gastroenterology and Hepatology, Kitasato University Kitasato Institute Hospital , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kitasato University Kitasato Institute Hospital , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Hibi","sequence":"additional","affiliation":[{"name":"Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2073-4234","authenticated-orcid":false,"given":"Taku","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital , Tokyo,","place":["Japan"]},{"name":"Department of Clinical Laboratory, Kitasato University 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