{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T01:02:33Z","timestamp":1775696553673,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Janus kinase inhibitors (JAKi) provide effective treatment for ulcerative colitis (UC), but inadequate response (IR) or intolerance occurs frequently. This study aimed to assess the effectiveness of a second JAKi in a real-world UC cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective multicenter cohort study encompassing 19 UK hospitals was undertaken. Primary outcome was clinical remission (Simple Clinical Colitis Activity Index\/partial Mayo Score\u2009\u2264\u20091) at weeks 8 and 24, based on available assessments. Biochemical (CRP\u2009\u2264\u20095mg\/L and fecal calprotectin\u2009\u2264\u2009200\u00b5g\/g) and endoscopic (Ulcerative Colitis Endoscopic Index of Severity\/Mayo Endoscopic Subscore\u2009\u2264\u20091) remission were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 131 patients with active UC were included. The majority (60%) had exposure to \u22653 advanced therapies and 50% required corticosteroids at induction. Clinical remission rates were 59% and 51% at weeks 8 and 24. Biochemical and endoscopic remission rates were 61% and 60% at week 8, and 47% and 32% at week 24. All disease activity parameters significantly reduced by week 8 (P\u2009&amp;lt;\u2009.001). At week 24 no difference was detected in clinical remission rates between those with primary non-response (42%) or secondary loss of response (52%) to their first JAKi (P\u2009=\u2009.518). Clinical remission did not differ between upadacitinib (54%) and filgotinib (36%), P\u2009=\u2009.253. Adverse events occurred in 27% of patients, and serious adverse events in 8%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this highly refractory cohort with active UC a second JAKi effectively achieved remission following IR to first JAKi. Type of first JAKi failure did not appear to influence clinical remission. No new safety signals were found.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaf154","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T11:21:08Z","timestamp":1755516068000},"source":"Crossref","is-referenced-by-count":2,"title":["Is 2nd JAKi treatment for UC worth the effort? A retrospective, multi-centre UK study"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1572-2172","authenticated-orcid":false,"given":"Chandni","family":"Radia","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, King\u2019s College Hospital NHS Foundation Trust , London, SE5 9RS,","place":["United Kingdom"]},{"name":"School of Immunology and Microbial Sciences, King\u2019s College London Faculty of Life Sciences & Medicine , London, WC2R 2LS,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaa","family":"Danso","sequence":"additional","affiliation":[{"name":"Gastroenterology, Barts Health NHS Trust , London, E1 1BB,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Gastroenterology, County Durham and Darlington NHS Foundation Trust , Darlington, DL3 6HX,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Hale","sequence":"additional","affiliation":[{"name":"Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield, S10 2JF,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6144-1369","authenticated-orcid":false,"given":"Alexander T","family":"Elford","sequence":"additional","affiliation":[{"name":"Edinburgh IBD Unit, Western General Hospital , Edinburgh, EH4 2XU,","place":["United Kingdom"]},{"name":"Medicine, The University of Melbourne , Melbourne, VIC, 3010,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chirag","family":"Patel","sequence":"additional","affiliation":[{"name":"Gastroenterology, Guy\u2019s and St Thomas\u2019 Hospitals NHS Trust , London, SE1 7EH,","place":["United 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3UJ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie Han","family":"Yeo","sequence":"additional","affiliation":[{"name":"Gastroenterology, University College London Hospitals NHS Foundation Trust , London, NW1 2BU,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Allah-Ditta","sequence":"additional","affiliation":[{"name":"Gastroenterology, Calderdale and Huddersfield NHS Foundation Trust , Huddersfield, HX3 0PW,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Bishara","sequence":"additional","affiliation":[{"name":"Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust , Exeter, EX2 5DW,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karishma","family":"Sethi-Arora","sequence":"additional","affiliation":[{"name":"Gastroenterology, Northern Care Alliance 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