{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T01:37:46Z","timestamp":1765157866599,"version":"build-2065373602"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Long-term outcomes and potential benefits of evolved treatment strategies in patients with Crohn\u2019s disease (CD) undergoing a second ileocolic resection (second surgery) are not well characterized. This study aimed to evaluate the risk of a third surgery following second surgery in CD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This retrospective cohort study included CD patients undergoing second surgery between 2000\u20132021 in Amsterdam UMC. Primary outcome was a third surgery due to disease recurrence at the neoterminal ileum. Two cohorts were compared to assess changes over time: C1 (2000\u20132009) and C2 (2010\u20132021).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 110 patients were included (69 women [62.7%]; median age, 39\u2009years [IQR 30\u201350]). The rates of third surgery were 12.1% at 5-years and 24.9% at 10-years. Use of prophylactic advanced therapies increased over time (C1: 16.4% vs C2: 41.7%, P\u2009=\u2009.004). However, the 5-year risk of third surgery was similar in both periods (C1: 12.5% vs C2: 11.5%, P\u2009=\u2009.45). Similarly, there was no statistically significant difference in third surgery risk between patients treated with vs without prophylactic advanced therapies (HR, 0.87 [95% CI, 0.37\u20132.02]). Most redo surgeries were performed for stricturing disease, even when the first surgery was for a different indication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Following second surgery, the 5-year third surgery rate is 12.1%, which has remained stable over the past two decades. No statistically significant reduction in third surgery rates were observed in patients receiving prophylactic advanced therapies. This may reflect both the predominantly stricturing disease as indication for redo surgery, which is typically less amenable to medical treatment, and the shorter follow-up in C2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaf156","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T11:51:13Z","timestamp":1755690673000},"source":"Crossref","is-referenced-by-count":1,"title":["Impact of advanced therapies on surgical recurrence following second ileocolic resection in Crohn\u2019s disease"],"prefix":"10.1093","volume":"19","author":[{"given":"Anouck E G","family":"Haanappel","sequence":"first","affiliation":[{"name":"Department of Surgery, Amsterdam UMC , Location VUmc , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tycho B","family":"Moojen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC , Location VUmc , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malaika S","family":"Vlug","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC , Location VUmc , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6094-8950","authenticated-orcid":false,"given":"Roel","family":"Hompes","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC , Location VUmc , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9425-8683","authenticated-orcid":false,"given":"Christianne J","family":"Buskens","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC , Location VUmc , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem A","family":"Bemelman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC , Location VUmc , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"2025102819153881100_jjaf156-B1","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1136\/gut.2010.234617","article-title":"Surgery for adult Crohn\u2019s disease: what is the actual risk?","volume":"60","author":"Bouguen","year":"2011","journal-title":"Gut"},{"key":"2025102819153881100_jjaf156-B2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/SLA.0000000000003395","article-title":"Decreasing trends in intestinal resection and re-resection in Crohn\u2019s disease: a nationwide cohort study","volume":"273","author":"Beelen","year":"2021","journal-title":"Ann Surg"},{"key":"2025102819153881100_jjaf156-B3","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1002\/bjs.11659","article-title":"Decrease in primary but not in secondary abdominal surgery for Crohn\u2019s disease: nationwide cohort study, 1990-2014","volume":"107","author":"Kalman","year":"2020","journal-title":"Br J Surg"},{"key":"2025102819153881100_jjaf156-B4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/apt.16114","article-title":"The risk of later surgery at the anastomotic site following right hemicolectomy for Crohn\u2019s disease in a national cohort of 12 230 patients","volume":"53","author":"King","year":"2021","journal-title":"Aliment Pharmacol Ther"},{"key":"2025102819153881100_jjaf156-B5","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/S2468-1253(20)30117-5","article-title":"Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn\u2019s disease: retrospective long-term follow-up of the lir! 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A prospective multicentric cohort study of the getaid chirurgie","volume":"13","author":"Abdalla","year":"2019","journal-title":"J Crohns Colitis"},{"key":"2025102819153881100_jjaf156-B24","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/DCR.0000000000002675","article-title":"Redo ileocolic resection is not an independent risk factor for anastomotic leak in recurrent Crohn\u2019s disease","volume":"66","author":"Yang","year":"2023","journal-title":"Dis Colon Rectum"},{"key":"2025102819153881100_jjaf156-B25","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/bjs.10595","article-title":"Short- and medium-term outcomes following primary ileocaecal resection for Crohn\u2019s disease in two specialist centres","volume":"104","author":"de Buck van Overstraeten","year":"2017","journal-title":"Br J Surg"}],"container-title":["Journal of Crohn\u2019s and Colitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/advance-article-pdf\/doi\/10.1093\/ecco-jcc\/jjaf156\/64103502\/jjaf156.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/9\/jjaf156\/64103502\/jjaf156.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/9\/jjaf156\/64103502\/jjaf156.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:15:47Z","timestamp":1761693347000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/doi\/10.1093\/ecco-jcc\/jjaf156\/8239295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,28]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjaf156","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"type":"print","value":"1873-9946"},{"type":"electronic","value":"1876-4479"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,8,21]]},"article-number":"jjaf156"}}