{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:07:58Z","timestamp":1781215678949,"version":"3.54.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"CIBEREHD and Instituto de Salud Carlos III","award":["PI16\/01296"],"award-info":[{"award-number":["PI16\/01296"]}]},{"name":"CIBEREHD and Instituto de Salud Carlos III","award":["PI19\/01034"],"award-info":[{"award-number":["PI19\/01034"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Identifying proteomic signatures in treatment-na\u00efve individuals newly diagnosed with inflammatory bowel disease (IBD) may provide insights into the underlying pathophysiological mechanisms of the disease and aid in distinguishing Crohn\u2019s disease (CD) from ulcerative colitis (UC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>In the discovery phase, label-free quantitative proteomics was performed to analyze proteomic profiles in serum extracellular vesicles (EVs), serum, urine, and intestinal tissue from 100 newly diagnosed IBD patients (50 CD and 50 UC), and 51 healthy controls (HC). Serum candidate biomarkers were validated using ELISA in a separate subset cohort (87 CD, 134 UC, and 99 HC), and immunohistochemistry was performed on biopsies from the discovery cohort to confirm findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 419 proteins in serum EVs, 468 in serum, 683 in urine, and 2603 in intestinal tissue. ELISA results showed lower levels of TTR and APOC3 and higher levels of ATRN in UC patients compared to HC. Similarly, CD patients showed lower TTR and higher ATRN levels compared to HC. Moreover, serum protein S10A9 was differentially upregulated in CD vs UC. Immunohistochemistry revealed increased PRDX4 and AZU1 expression in the ileum of CD patients, whereas AOFB expression was lower in the ileum of CD and in the left colon of both CD and UC compared to HC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This comprehensive proteomic study has identified a set of proteins differentially expressed in IBD, which may contribute to a better understanding of its mechanisms and hold promise as candidate biomarkers. Although these findings are preliminary, they warrant further investigation to evaluate their diagnostic and therapeutic relevance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaf177","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T11:58:55Z","timestamp":1759492735000},"source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive proteomic profile in newly diagnosed patients with inflammatory bowel disease: identification of potential biomarkers"],"prefix":"10.1093","volume":"19","author":[{"given":"Montse","family":"Bald\u00e1n-Mart\u00edn","sequence":"first","affiliation":[{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibon","family":"Iloro","sequence":"additional","affiliation":[{"name":"Proteomics Platform, CIC bioGUNE, BRTA (Basque Research & Technology Alliance), CIBEREHD , Derio,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9115-3202","authenticated-orcid":false,"given":"Mikel","family":"Azkargorta","sequence":"additional","affiliation":[{"name":"Proteomics Platform, CIC bioGUNE, BRTA (Basque Research & Technology Alliance), CIBEREHD , Derio,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Soleto","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena","family":"Orejudo","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mercado","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Su\u00e1rez-Trujillo","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"S\u00e1nchez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garre","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabino","family":"Riestra","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central de Asturias and Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) , Oviedo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Rivero","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla and IDIVAL , Santander,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Servicio Medicina Digestiva Hospital General Universitario Dr Balmis de Alicante; IIS ISABIAL, Hospital General Universitario Dr Balmis, Alicante and CIBEREHD, Instituto de Salud Carlos III , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-4578","authenticated-orcid":false,"given":"Iago","family":"Rodr\u00edguez-Lago","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Galdakao; Biobizkaia Health Research Institute , Galdakao,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Fern\u00e1ndez-Salazar","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid , Valladolid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2384-4524","authenticated-orcid":false,"given":"Daniel","family":"Ceballos","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Gran Canaria Dr Negr\u00edn , Las Palmas de Gran Canaria,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda and IMIBIC , C\u00f3rdoba,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4353-569X","authenticated-orcid":false,"given":"Mariam","family":"Aguas","sequence":"additional","affiliation":[{"name":"Health Research Institute (IISLaFe), Hospital Universitari i Politecnic La Fe , Valencia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iria","family":"Bast\u00f3n-Rey","sequence":"additional","affiliation":[{"name":"Complexo Hospitalario Universitario de Santiago de Compostela and Santiago de Compostela Health Research Institute , Santiago de Compostela,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4610-0886","authenticated-orcid":false,"given":"Fernando","family":"Bermejo","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Fuenlabrada , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8233-9638","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Casanova","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufo H","family":"Lorente-Poyatos","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Ciudad Real , Ciudad Real,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Ber","sequence":"additional","affiliation":[{"name":"Hospital San Jorge , Huesca,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ginard","sequence":"additional","affiliation":[{"name":"Hospital Universitari Son Espases , Palma de Mallorca,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Esteve","sequence":"additional","affiliation":[{"name":"Hospital Universitari Mutua Terrasa and CIBEREHD , Terrasa,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8476-1672","authenticated-orcid":false,"given":"Ruth","family":"De Francisco","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central de Asturias and Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) , Oviedo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-7005","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla and IDIVAL , Santander,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5105-1201","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Franc\u00e9s","sequence":"additional","affiliation":[{"name":"Grupo de Inmunobiologia Hep\u00e1tica e Intestinal, Dpto. Medicina Cl\u00ednica e Instituto IDIBE, Universidad Miguel Hern\u00e1ndez , San Juan, Alicante,","place":["Spain"]},{"name":"IIS ISABIAL, Hospital General Universitario Dr Balmis, Alicante and CIBEREHD, Instituto de Salud Carlos III , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Cabriada","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Galdakao; Biobizkaia Health Research Institute , Galdakao,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Soto","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda and IMIBIC , C\u00f3rdoba,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6619-1511","authenticated-orcid":false,"given":"Pilar","family":"Nos","sequence":"additional","affiliation":[{"name":"Health Research Institute (IISLaFe), Hospital Universitari i Politecnic La Fe , Valencia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-1477","authenticated-orcid":false,"given":"Manuel Barreiro-de","family":"Acosta","sequence":"additional","affiliation":[{"name":"Complexo Hospitalario Universitario de Santiago de Compostela and Santiago de Compostela Health Research Institute , Santiago de Compostela,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Guerra","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Fuenlabrada , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Herv\u00edas","family":"Cruz","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Ciudad Real , Ciudad Real,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Dom\u00ednguez Cajal","sequence":"additional","affiliation":[{"name":"Hospital San Jorge , Huesca,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Royo","sequence":"additional","affiliation":[{"name":"Hospital Universitari Son Espases , Palma de Mallorca,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Aceituno","sequence":"additional","affiliation":[{"name":"Hospital Universitari Mutua Terrasa and CIBEREHD , Terrasa,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa B","family":"Mart\u00edn-C\u00f3freces","sequence":"additional","affiliation":[{"name":"Immunology Unit from Hospital Universitario de la Princesa, UAM and IIS-Princesa , Madrid,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Cardiovasculares (CIBERCV) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Elortza","sequence":"additional","affiliation":[{"name":"Proteomics Platform, CIC bioGUNE, BRTA (Basque Research & Technology Alliance), CIBEREHD , Derio,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-3445","authenticated-orcid":false,"given":"Javier P","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9275-4242","authenticated-orcid":false,"given":"Mar\u00eda","family":"Chaparro","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid (UAM), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"2025111000105866500_jjaf177-B1","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"2025111000105866500_jjaf177-B2","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.3390\/JCM10132885\/S1","article-title":"Incidence, clinical characteristics and management of inflammatory bowel disease in Spain: Large-scale epidemiological study","volume":"10","author":"Chaparro","year":"2021","journal-title":"J Clin Med"},{"key":"2025111000105866500_jjaf177-B3","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/nature01511","article-title":"Mass spectrometry-based proteomics","volume":"422","author":"Aebersold","year":"2003","journal-title":"Nature"},{"key":"2025111000105866500_jjaf177-B4","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1093\/ECCO-JCC\/JJY158","article-title":"Clinical usefulness of proteomics in inflammatory bowel disease: a comprehensive review","volume":"13","author":"Gisbert","year":"2019","journal-title":"J Crohns Colitis"},{"key":"2025111000105866500_jjaf177-B5","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1093\/IBD\/IZAA352","article-title":"Tissue proteomic approaches to understand the pathogenesis of inflammatory bowel disease","volume":"27","author":"Baldan-Martin","year":"2021","journal-title":"Inflamm Bowel Dis"},{"key":"2025111000105866500_jjaf177-B6","doi-asserted-by":"publisher","first-page":"i123","DOI":"10.1093\/ecco-jcc\/jjab232.118","article-title":"DOP79 biomarkers for IBD using OLINK Proteomics inflammation panel: preliminary results from the COLLIBRI consortium","volume":"16","author":"Sudhakar","year":"2022","journal-title":"J Crohns Colitis"},{"key":"2025111000105866500_jjaf177-B7","doi-asserted-by":"publisher","first-page":"i314","DOI":"10.1093\/ecco-jcc\/jjac190.0284","article-title":"P154 A novel serum protein signature as biomarker for Inflammatory Bowel Disease: a diagnostic performance and prediction modelling study using data from two independent inception cohorts","volume":"17","author":"Bazov","year":"2023","journal-title":"J Crohns Colitis"},{"key":"2025111000105866500_jjaf177-B8","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1093\/ecco-jcc\/jjab178","article-title":"ECCO guidelines on therapeutics in ulcerative colitis: medical treatment","volume":"16","author":"Raine","year":"2022","journal-title":"J Crohns Colitis"},{"key":"2025111000105866500_jjaf177-B9","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1093\/ecco-jcc\/jjae091","article-title":"ECCO guidelines on therapeutics in Crohn\u2019s disease: medical treatment","volume":"18","author":"Gordon","year":"2024","journal-title":"J Crohns Colitis"},{"key":"2025111000105866500_jjaf177-B10","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/J.2517-6161.1995.TB02031.X","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J Royal Stat Soc Series B (Methodological)"},{"key":"2025111000105866500_jjaf177-B11","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1172\/JCI27883","article-title":"Liver X receptors as integrators of metabolic and inflammatory signaling","volume":"116","author":"Zelcer","year":"2006","journal-title":"J Clin Invest"},{"key":"2025111000105866500_jjaf177-B12","doi-asserted-by":"publisher","first-page":"100094","DOI":"10.1016\/J.JPI.2022.100094","article-title":"Probing predilection to Crohn\u2019s disease and Crohn\u2019s disease flares: a crowd-sourced bioinformatics approach","volume":"13","author":"Aljabban","year":"2022","journal-title":"J Pathol Inform"},{"key":"2025111000105866500_jjaf177-B13","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1196\/ANNALS.1361.058","article-title":"Systemic thromboembolism in inflammatory bowel disease: mechanisms and clinical applications","volume":"1051","author":"Twig","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"2025111000105866500_jjaf177-B14","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1053\/J.GASTRO.2010.06.070","article-title":"Risk factors associated with progression to intestinal complications of Crohn\u2019s disease in a population-based cohort","volume":"139","author":"Thia","year":"2010","journal-title":"Gastroenterology"},{"key":"2025111000105866500_jjaf177-B15","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/S10456-007-9074-0","article-title":"Angiogenesis and chronic inflammation: cause or consequence?","volume":"10","author":"Costa","year":"2007","journal-title":"Angiogenesis"},{"key":"2025111000105866500_jjaf177-B16","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.3748\/WJG.V26.I12.1242","article-title":"Roles of G protein-coupled receptors in inflammatory bowel disease","volume":"26","author":"Zeng","year":"2020","journal-title":"World J Gastroenterol"},{"key":"2025111000105866500_jjaf177-B17","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/J.CLNU.2016.06.004","article-title":"Is transthyretin a good marker of nutritional status?","volume":"36","author":"Delli\u00e8re","year":"2017","journal-title":"Clin Nutr"},{"key":"2025111000105866500_jjaf177-B18","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/J.EUPROT.2014.02.010","article-title":"Serum protein profiling of early and advanced stage Crohn\u2019s disease","volume":"3","author":"Piras","year":"2014","journal-title":"EuPA Open Proteom"},{"key":"2025111000105866500_jjaf177-B19","doi-asserted-by":"publisher","first-page":"E00500","DOI":"10.14309\/CTG.0000000000000500","article-title":"Apolipoprotein C3 is downregulated in patients with inflammatory bowel disease","volume":"13","author":"Hern\u00e1ndez-Camba","year":"2022","journal-title":"Clin Transl Gastroenterol"},{"key":"2025111000105866500_jjaf177-B20","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/ibd\/izad154","article-title":"Serum and urine metabolomic profiling of newly diagnosed treatment-na\u00efve inflammatory bowel disease patients","volume":"30","author":"Aldars-Garc\u00eda","year":"2024","journal-title":"Inflamm Bowel Dis"},{"key":"2025111000105866500_jjaf177-B21","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.3389\/FIMMU.2018.01298\/FULL","article-title":"S100A8\/A9 in inflammation","volume":"9","author":"Wang","year":"2018","journal-title":"Front Immunol"},{"key":"2025111000105866500_jjaf177-B22","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1002\/IJC.29671","article-title":"Inflammation-induced S100A8 activates Id3 and promotes colorectal tumorigenesis","volume":"137","author":"Zhang","year":"2015","journal-title":"Int J Cancer"},{"key":"2025111000105866500_jjaf177-B23","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.3389\/FIMMU.2017.01774\/FULL","article-title":"Suppression colitis and colitis-associated colon cancer by anti-S100a9 antibody in mice","volume":"8","author":"Zhang","year":"2017","journal-title":"Front Immunol"},{"key":"2025111000105866500_jjaf177-B24","doi-asserted-by":"publisher","first-page":"e38801","DOI":"10.1371\/JOURNAL.PONE.0038801","article-title":"Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis","volume":"7","author":"Lee","year":"2012","journal-title":"PLoS One"},{"key":"2025111000105866500_jjaf177-B25","doi-asserted-by":"publisher","first-page":"BSR20202384","DOI":"10.1042\/BSR20202384","article-title":"Integrated analysis of DNA methylation and gene expression profiles identified S100A9 as a potential biomarker in ulcerative colitis","volume":"40","author":"Su","year":"2020","journal-title":"Biosci Rep"},{"key":"2025111000105866500_jjaf177-B26","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/J.FREERADBIOMED.2018.12.024","article-title":"Elevated ER stress exacerbates dextran sulfate sodium-induced colitis in PRDX4-knockout mice","volume":"134","author":"Takagi","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"2025111000105866500_jjaf177-B27","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s004410100361","article-title":"Cellular localization of monoamine oxidase A and B in human tissues outside of the central nervous system","volume":"304","author":"Rodr\u00edguez","year":"2001","journal-title":"Cell Tissue Res"},{"key":"2025111000105866500_jjaf177-B28","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.3390\/ijms21082813","article-title":"Monoamine oxidase B expression correlates with a poor prognosis in colorectal cancer patients and is significantly associated with epithelial-to-mesenchymal transition-related gene signatures","volume":"21","author":"Yang","year":"2020","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/advance-article-pdf\/doi\/10.1093\/ecco-jcc\/jjaf177\/64555789\/jjaf177.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/10\/jjaf177\/64555789\/jjaf177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/19\/10\/jjaf177\/64555789\/jjaf177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T05:11:02Z","timestamp":1762751462000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/doi\/10.1093\/ecco-jcc\/jjaf177\/8277933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,11,8]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjaf177","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,10]]},"article-number":"jjaf177"}}