{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:29:14Z","timestamp":1793212154931,"version":"4.5.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100022924","name":"Grupo Espa\u00f1ol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100022924","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tillots Pharma"},{"name":"Gobierno Vasco-Eusko Jaurlaritza","award":["2020111061"],"award-info":[{"award-number":["2020111061"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral corticosteroids remain the treatment of choice for moderately active ulcerative colitis (UC), achieving clinical remission in 30%-60% of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the rates of steroid-free clinical-endoscopic remission at weeks 8 and 54 in patients treated with 3 methyl-prednisolone pulses before oral corticosteroids in moderately active UC versus those only receiving oral corticosteroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, open, multicentre, randomized, controlled trial. Patients with left\/extensive, moderately active UC, naive to immunosuppressants and biological agents, were randomized to receive conventional treatment (CT) with oral prednisone 60\u2009mg\/day or the same regimen preceded by an additional daily pulse (AP) of 500\u2009mg of methyl-prednisolone for 3 days. All patients who responded started oral mesalazine and were followed up until month 12 or clinical relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy-five patients were randomized: 39 were allocated to the CT arm and 36 to the AP arm. Overall, 21 patients achieved clinical-endoscopic remission (28%; 95% confidence interval [CI]: 23%-33%) at both weeks 8 and 54 without needing rescue treatments, being not significantly different between both study groups (23% [95%CI: 14%-32%] CT vs. 33% [95%CI: 21%-45%] AP; P\u2009=\u20090.323). Patients in the AP group had higher rates of clinical response at day 3 and remission at day 7. No significant differences in adverse events were observed. Due to early termination, the study was underpowered, and findings should be interpreted as exploratory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The addition of 3 pulses of high-dose corticosteroids to a conventional regimen of oral prednisone does not improve medium and long-term clinical outcomes in moderately active UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration codes<\/jats:title>\n                    <jats:p>EudraCT number 2016-001170-15; ClinicalTrials.gov identifier NCT02921555.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaf182","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T16:22:10Z","timestamp":1763569330000},"source":"Crossref","is-referenced-by-count":3,"title":["Addition of pulse corticosteroids to oral prednisone in moderately active ulcerative colitis: a randomized, multicentre, open-label study by GETECCU"],"prefix":"10.1093","volume":"19","author":[{"given":"Jordina","family":"Lla\u00f3","sequence":"first","affiliation":[{"name":"Gastroenterology & Hepatology Department, Hospital Universitari Germans Trias i Pujol , Badalona,","place":["Spain"]},{"name":"Xarxa Assistencial Althaia Gastoenterology Department, , Manresa,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00edriam","family":"Ma\u00f1osa","sequence":"additional","affiliation":[{"name":"Gastroenterology & Hepatology Department, Hospital Universitari Germans Trias i Pujol , Badalona,","place":["Spain"]},{"name":"Centro de investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD),","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Mart\u00edn-Arranz","sequence":"additional","affiliation":[{"name":"H. Universitario La Paz, Instituto de Investigacion Sanitaria del Hospital Universitario La Paz Idipaz Gastoenterology Department, , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-8868","authenticated-orcid":false,"given":"Yamile","family":"Zabana","sequence":"additional","affiliation":[{"name":"Centro de investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD),","place":["Spain"]},{"name":"H.U. M\u00fatua Terrassa Gastoenterology Department, , Terrassa,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Navarro-Llavat","sequence":"additional","affiliation":[{"name":"H. Mois\u00e8s Broggi Gastoenterology Department, , Sant Joan Desp\u00ed,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"T\u00e9ller","sequence":"additional","affiliation":[{"name":"Xarxa Assistencial Althaia Gastoenterology Department, , Manresa,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Garcia-Planella","sequence":"additional","affiliation":[{"name":"H. de la Santa Creu i Sant Pau Gastoenterology Department, , Barcelona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9385-1415","authenticated-orcid":false,"given":"David","family":"Busquets","sequence":"additional","affiliation":[{"name":"H. Trueta Gastoenterology Department, , Girona,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Monfort","sequence":"additional","affiliation":[{"name":"Consorci Sanitari de Terrassa Gastoenterology Department,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Ram\u00f3n","family":"Pineda","sequence":"additional","affiliation":[{"name":"H. \u00c1lvaro Cunqueiro Gastoenterology Department, , Vigo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Centro de investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD),","place":["Spain"]},{"name":"H.G. 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