{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:20:16Z","timestamp":1783984816405,"version":"3.55.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Intestinal ultrasound (IUS) is a promising tool for predicting treatment response in inflammatory bowel disease (IBD). We aimed to systematically review existing literature on the predictive value of IUS for treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search was performed until May 2025. We included articles assessing treatment response in IBD using IUS. Data were analyzed separately for Crohn\u2019s Disease (CD), ulcerative colitis (UC) and acute severe ulcerative colitis (ASUC). Pooled data analysis was performed for bowel wall thickness (BWT) in CD patients starting anti-TNF (tumor necrosis factor).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 31 articles were included (18 CD, 9 UC, and 4 ASUC). In 8\/10 CD studies, IUS at week 4-8 could distinguish future responders, with BWT change ranging from \u221243% to \u221214.6% in responders vs. \u221214% to\u2009+\u20092% in nonresponders. In the pooled data analysis of anti-TNF-treated CD patients (n\u2009=\u2009236) a 23% decrease from baseline at week 4-8 (area under the receiver operating characteristic curve [AUROC] 0.82) and 27% decrease at week 12-16 (AUROC 0.78) could predict future response. In 2\/2 UC studies, IUS after 4-8\u2009weeks could predict future endoscopic remission vs. non-remission with a decrease in BWT ranging from \u221255% to \u221249% vs. \u221238% to \u221217% respectively. In ASUC, change in BWT after 1-3\u2009days could predict need for salvage therapy (\u221234% vs. \u221210%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intestinal ultrasound predicts response at an early stage after treatment initiation, both in CD as well as in UC. In anti-TNF-treated CD patients, 23% and 27% decrease in BWT after 4-8\u2009weeks and 12-16\u2009weeks of treatment initiation predicts outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjag017","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:45:25Z","timestamp":1770986725000},"source":"Crossref","is-referenced-by-count":1,"title":["The predictive value of intestinal ultrasound for treatment response in inflammatory bowel disease: a systematic review and pooled data analysis"],"prefix":"10.1093","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8166-7022","authenticated-orcid":false,"given":"Johanna M B W","family":"Vos","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam , Amsterdam,","place":["The Netherlands"]},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Research 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Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7457-8353","authenticated-orcid":false,"given":"Maarten J","family":"Pruijt","sequence":"additional","affiliation":[{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam UMC , Amsterdam,","place":["The Netherlands"]},{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faridi S","family":"Jamaludin","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Centre, University of Amsterdam, Medical Library AMC , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert R A M","family":"D\u2019Haens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A","family":"Benninga","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart G P","family":"Koot","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina B","family":"Gecse","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC , Amsterdam,","place":["The 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