{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:02:44Z","timestamp":1793865764757,"version":"4.6.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Real-world data are needed to better understand the burden and outcomes of patients hospitalized with severe ulcerative colitis (UC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analyzed US electronic health record (EHR) data with linked insurance claims to identify adults hospitalized for UC who received intravenous corticosteroids during an inpatient admission (index hospitalization) between January 1, 2014, and December 31, 2022, with \u2265180\u2009days of prior EHR activity. Results were analyzed for the overall cohort, in three subgroups: (1) no prior UC diagnosis in the EHR, (2) prior UC diagnosis without prior advanced therapy, and (3) prior UC with prior advanced therapy, and in a nested cohort of patients discharged without colectomy. Multivariable analyses assessed factors associated with colectomy before discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, we identified 9716 patients (mean [SD] age, 46.3 [17.4] years); 83.3% had a previous diagnosis of UC and 23.8% had prior biologic use for UC. During hospitalization, 13.1% received advanced therapy; 12.2% underwent colectomy. The rate of colectomy was 12.6% in subgroup 1, 9.2% in subgroup 2, and 19.6% in subgroup 3 (P\u2009&amp;lt;\u2009.0001). Prior UC diagnosis with prior advanced therapy use and abnormal\/missing albumin labs were associated with higher risk of colectomy. The cumulative risk of colectomy &amp;lt;1 year after index hospitalization was 20.4% overall and 18.5%, 16.1%, and 32.7% in subgroups 1, 2, and 3, respectively. In the nested cohort (n\u2009=\u20094383), one-third received advanced therapy within 90\u2009days; 38.4% experienced a UC-related hospitalization &amp;lt;1\u2009year after index hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data from a large contemporary cohort elucidate the burden and outcomes for patients hospitalized with severe UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjag040","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T12:43:00Z","timestamp":1772714580000},"source":"Crossref","is-referenced-by-count":2,"title":["Real-world patient characteristics, treatments, and outcomes during and after severe ulcerative colitis hospitalization"],"prefix":"10.1093","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5855-9873","authenticated-orcid":false,"given":"Tim","family":"Raine","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust , Cambridge, CB2 0QQ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D","family":"Lewis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-7714","authenticated-orcid":false,"given":"Gareth C","family":"Parkes","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Royal London Hospital, Barts Health NHS Trust , London, E1 1FR,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Millie D","family":"Long","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Center for Gastrointestinal Biology and Disease, University of North Carolina , Chapel Hill, NC 27514,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parambir S","family":"Dulai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Northwestern University , Chicago, IL 60208,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A","family":"Berinstein","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Michigan , Ann Arbor, MI 48109,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S","family":"Cheifetz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Beth Israel Deaconess Medical Center , Boston, MA 02215,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyu","family":"Chen","sequence":"additional","affiliation":[{"name":"AbbVie Inc ., North Chicago, IL 60064,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7010-2024","authenticated-orcid":false,"given":"Carrie","family":"Huisingh","sequence":"additional","affiliation":[{"name":"AbbVie Inc ., North Chicago, IL 60064,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Eccleston","sequence":"additional","affiliation":[{"name":"AbbVie Inc ., North Chicago, IL 60064,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Kujawski","sequence":"additional","affiliation":[{"name":"AbbVie Inc ., North Chicago, IL 60064,","place":["United 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