{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:14:47Z","timestamp":1789132487380,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ileo-colonoscopy provides accurate assessment of mucosal inflammation in Crohn\u2019s disease. Magnetic resonance imaging (MRI) offers a non-invasive alternative. MRI-based scores such as the simplified MaRIA (sMaRIA) have been proposed for measuring treatment response in clinical trials, but systematic comparisons with endoscopic scoring systems in prospective datasets are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PROFILE trial participants underwent ileo-colonoscopy and small bowel MRI at baseline and week 48 (end-of-trial). Using this dataset our primary objective was to assess the correlation between Simple Endoscopic Score for Crohn\u2019s Disease (SES-CD) and sMaRIA scores using contemporaneous ileo-colonoscopy and MRI studies. We also assessed the utility of sMaRIA as a clinical trial endpoint, and correlation between baseline sMaRIA and need for future surgery. Endoscopic and MRI remission were defined as SES-CD and sMaRIA scores of 0. Ulcer subscores were also examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, :285 patients had paired baseline ileo-colonoscopy and MRI studies and 220 had paired end-of-trial studies\u2014undertaken a median of 35 and 22\u2009days apart respectively. Correlation between total SES-CD and sMaRIA scores on end-of-trial studies was moderate (Spearman\u2019s \u03c1\u2009=\u20090.428). MRI\/sMaRIA identified only 18\/143 ulcerated segments seen on ileo-colonoscopy. While remission rates between PROFILE treatment arms were significantly different on ileo-colonoscopy\/SES-CD (P\u2009=\u2009.005), this difference was not seen on MRI\/sMaRIA (P\u2009=\u2009.564). Patients requiring abdominal surgery had higher baseline sMaRIA scores than those who did not (P\u2009=\u2009.015), while SES-CD scores were not different between these groups (P\u2009=\u2009.830).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MRI should be considered as complementary to ileo-colonoscopy for assessing ileal Crohn\u2019s disease. sMaRIA should not replace SES-CD in clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjag056","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:43:35Z","timestamp":1775821415000},"source":"Crossref","is-referenced-by-count":3,"title":["Magnetic resonance imaging-based simplified MaRIA scores are associated with future surgery in Crohn\u2019s disease, but modest correlation with ileo-colonoscopic inflammation limits their utility in clinical trials: results from the PROFILE trial"],"prefix":"10.1093","volume":"20","author":[{"given":"Megha","family":"Bhandari","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust , Cambridge, CB2 0QQ,","place":["United Kingdom"]},{"name":"Department of Medicine, University of Cambridge School of Clinical Medicine , Cambridge, CB2 0AW,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6385-6971","authenticated-orcid":false,"given":"Mohmmed Tauseef","family":"Sharip","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust , Cambridge, CB2 0QQ,","place":["United Kingdom"]},{"name":"Department of Medicine, University of Cambridge School of Clinical Medicine , Cambridge, CB2 0AW,","place":["United 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