{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:15:04Z","timestamp":1783790104081,"version":"3.55.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Starting Grant","award":["ERC-2018-StG-804135"],"award-info":[{"award-number":["ERC-2018-StG-804135"]}]},{"name":"Starting Grant","award":["ERC-2024-CoG-101170920"],"award-info":[{"award-number":["ERC-2024-CoG-101170920"]}]},{"DOI":"10.13039\/100019180","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020"},{"name":"ANR grants EMULBIONT","award":["ANR-21-CE15-0042-01"],"award-info":[{"award-number":["ANR-21-CE15-0042-01"]}]},{"name":"DREAM","award":["ANR-20-PAMR-0002"],"award-info":[{"award-number":["ANR-20-PAMR-0002"]}]},{"name":"the Fondation de l\u2019Avenir","award":["AP-RM-21-032"],"award-info":[{"award-number":["AP-RM-21-032"]}]},{"name":"Fondation pour la Recherche Medicale FoodHabits","award":["ENV202409018912"],"award-info":[{"award-number":["ENV202409018912"]}]},{"name":"AFA Crohn RCH France"},{"name":"France 2030 investment plan managed by the National Research Agency","award":["ANR-24-PESA-0008"],"award-info":[{"award-number":["ANR-24-PESA-0008"]}]},{"name":"France 2030 investment plan managed by the National Research Agency","award":["ANR-23-IAHU-0012"],"award-info":[{"award-number":["ANR-23-IAHU-0012"]}]},{"name":"R\u00e9gion Ile-de-France DIM BioConvergence for Health (BioConvS) and DIM One HEALTH 2.0"},{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The rising incidence of Crohn\u2019s disease (CD) in Westernized countries has been linked to changes in diet and increased consumption of food additives, yet the mechanisms by which these factors fuel intestinal inflammation remain unclear. Adherent-invasive Escherichia coli (AIEC), a pathobiont involved in CD pathogenesis, lacks a clear genetic hallmark but exhibits intestinal colonization and virulence traits, raising questions about the evolutionary forces promoting its emergence among select individuals. Here, we investigated how chronic exposure to two common dietary emulsifiers, carboxymethylcellulose (CMC) and polysorbate 80 (P80), along with host inflammation, drives AIEC genomic evolution and pathogenic potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Wild-type and Il10-deficient mice were monocolonized with AIEC and chronically exposed to CMC, P80, or water. Bacterial isolates were collected and analyzed for genomic diversification, mutations, and phenotype both in vitro and in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Emulsifiers accelerated AIEC genomic diversification and selected for mutations linked to increased motility, invasion, and pro-inflammatory activity. Moreover, dietary emulsifier-evolved strains displayed a marked fitness advantage in vivo, outcompeting their counterparts in murine hosts, with the greatest advantage observed when evolution occurred under inflammatory conditions. Notably, evolutionary pathways and phenotypic outcomes were shaped by both emulsifier and the host\u2019s inflammatory status, highlighting synergy between diet and host genetics in fostering pro-inflammatory pathobionts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings provide an evolutionary framework connecting modern dietary habits to the emergence of pathogenic AIEC strains, and underscore the importance of dietary interventions in individuals at risk for inflammatory bowel disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjag088","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:38:29Z","timestamp":1783532309000},"source":"Crossref","is-referenced-by-count":0,"title":["Dietary emulsifiers and host inflammation synergistically drive genomic evolution of Crohn\u2019s disease-associated\n                    <i>Escherichia coli<\/i>\n                    toward enhanced pathogenicity"],"prefix":"10.1093","volume":"20","author":[{"given":"H\u00e9lo\u00efse","family":"Rytter","sequence":"first","affiliation":[{"name":"Microbiome-Host Interactions, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM U1306, CNRS UMR6047 , Paris, 75015,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Chevarin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne\/Inserm\/U1071, USC-INRAE1382, M2iSH , Clermont-Ferrand, 63000,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Martin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne\/Inserm\/U1071, USC-INRAE1382, M2iSH , Clermont-Ferrand, 63000,","place":["France"]},{"name":"CHU Clermont-Ferrand, 3iHP, Service d\u2018H\u00e9pato-Gastro Ent\u00e9rologie , Clermont-Ferrand, 63003,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Bruder","sequence":"additional","affiliation":[{"name":"CIRB\u2014Coll\u00e8ge de France, CNRS, INSERM, Universit\u00e9 PSL , Paris, 75231,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Denizot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne\/Inserm\/U1071, USC-INRAE1382, M2iSH , Clermont-Ferrand, 63000,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Tenaillon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Cochin , Paris, 75014,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Esp\u00e9li","sequence":"additional","affiliation":[{"name":"CIRB\u2014Coll\u00e8ge de France, CNRS, INSERM, Universit\u00e9 PSL , Paris, 75231,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Birer","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, University Hospital of Clermont-Ferrand , Clermont-Ferrand, 63000,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Barnich","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne\/Inserm\/U1071, USC-INRAE1382, M2iSH , Clermont-Ferrand, 63000,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3104-620X","authenticated-orcid":false,"given":"Emilie","family":"Viennois","sequence":"additional","affiliation":[{"name":"Center for Research on Inflammation, UMR 1149, INSERM, Universit\u00e9 Paris Cit\u00e9 , Paris, 75018,","place":["France"]},{"name":"CHRU Nancy, IHU Infiny, Nancy, F54000, 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