{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T03:28:01Z","timestamp":1786332481737,"version":"build-2736575974"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>5-Aminosalicylic acid (5-ASA) remains the first-line therapy for mild-to-moderate ulcerative colitis (UC). Modern treatment goals extend beyond symptom control to include steroid-free remission, endoscopic healing, and biomarker normalization. Real-world evidence on 5-ASA\u2019s ability to achieve these targets is limited. This study assessed remission levels and associated factors in Belgian UC patients in clinical remission on 5-ASA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional, multicenter, phase 4 study included UC patients in clinical remission (PRO-2\u2009\u2264\u20091, no rectal bleeding) treated with 5-ASA for \u22656\u2009months. Patients receiving corticosteroids, immunomodulators, or advanced therapies were excluded. Outcomes were complete clinical remission (PRO-2\u2009=\u20090, no urgency), endoscopic remission (MES \u2264 1, UCEIS \u2264 1), complete endoscopic remission (MES = 0), histological remission (Geboes 0-1), biological remission (fecal calprotectin &amp;lt;150\u2009\u00b5g\/g), and deep remission (clinical, endoscopic, and histological). Adherence was assessed using MARS-5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 198 patients were enrolled (median age 50\u2009years; 41% female). Treatment was oral 5-ASA only (n\u2009=\u2009134, 68%), rectal only (n\u2009=\u200919, 9%), or combination (n\u2009=\u200945, 23%). Biological remission was observed in 78%, endoscopic remission in 87%, complete endoscopic remission in 70%, and histological remission in 80%. Deep remission occurred in 24%, limited by persistent urgency (63%). Adherence was high (median MARS-5: 24). Oral 5-ASA only was significantly associated with endoscopic remission (P\u2009&amp;lt;\u2009.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this real-world Belgian cohort, patients in clinical remission on 5-ASA achieved high rates of objective remission, while deep remission was low because of persistent urgency. These findings confirm 5-ASA\u2019s continued relevance in mild-to-moderate UC and highlight the importance of addressing residual symptoms despite mucosal healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjag100","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:18:50Z","timestamp":1782854330000},"source":"Crossref","is-referenced-by-count":0,"title":["Characterization of remission levels in patients with ulcerative colitis treated with 5-aminosalicylates: results of the cross-sectional CARUC-ASA study by the Belgian IBD Research and Development Group"],"prefix":"10.1093","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5490-4350","authenticated-orcid":false,"given":"Catherine","family":"Reenaers","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, University Hospital of Li\u00e8ge, Li\u00e8ge University , 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Gent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"De Zutter","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sint-Andriesziekenhuis , Tielt,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Rahier","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU UCL Namur, Universit\u00e9 catholique de Louvain , Yvoir,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1092-7128","authenticated-orcid":false,"given":"Michael","family":"Somers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Antwerpen , Antwerpen,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dries","family":"Reynders","sequence":"additional","affiliation":[{"name":"Gent University Department of Mathematics, Computer Science and Statistics, , Gent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Vansteenkiste","sequence":"additional","affiliation":[{"name":"Belgian Inflammatory Bowel Disease Research and Development (BIRD)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-083X","authenticated-orcid":false,"given":"Ingrid","family":"Arijs","sequence":"additional","affiliation":[{"name":"Belgian Inflammatory Bowel Disease Research and Development (BIRD)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Louis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital of Li\u00e8ge, Li\u00e8ge University , Li\u00e8ge,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Belgian IBD Research and Development Group 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