{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:55:36Z","timestamp":1790542536486,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,28]]},"DOI":"10.1093\/ecco-jcc\/jjy034","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T11:52:41Z","timestamp":1521028361000},"page":"860-869","source":"Crossref","is-referenced-by-count":26,"title":["Dietary Supplementation With a Bacillus Superoxide Dismutase Protects Against \u03b3-Radiation-induced Oxidative Stress and Ameliorates Dextran Sulphate Sodium-induced Ulcerative Colitis in Mice"],"prefix":"10.1093","volume":"12","author":[{"given":"Ji-Eun","family":"Kang","sequence":"first","affiliation":[{"name":"GenoFocus, Inc., Techno 1-ro, Yuseong-gu, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Do","family":"Kim","sequence":"additional","affiliation":[{"name":"GenoFocus, Inc., Techno 1-ro, Yuseong-gu, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Young","family":"Park","sequence":"additional","affiliation":[{"name":"GenoFocus, Inc., Techno 1-ro, Yuseong-gu, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Gu","family":"Pan","sequence":"additional","affiliation":[{"name":"GenoFocus, Inc., Techno 1-ro, Yuseong-gu, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"GenoFocus, Inc., Techno 1-ro, Yuseong-gu, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Young","family":"Yum","sequence":"additional","affiliation":[{"name":"GenoFocus, Inc., Techno 1-ro, Yuseong-gu, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"key\n\t\t\t\t20180628065747_CIT0001","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1007\/s11095-013-1113-5","article-title":"Superoxide dismutase administration, a potential therapy against oxidative stress related diseases: several routes of supplementation and proposal of an original mechanism of action","volume":"30","author":"Carillon","year":"2013","journal-title":"Pharm Res"},{"key":"key\n\t\t\t\t20180628065747_CIT0002","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1089\/ars.2011.3999","article-title":"Superoxide dismutases: role in redox signaling, vascular function, and diseases","volume":"15","author":"Fukai","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"key\n\t\t\t\t20180628065747_CIT0003","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.nut.2014.10.006","article-title":"Therapeutic value of oral supplementation with melon superoxide dismutase and wheat gliadin combination","volume":"31","author":"Romao","year":"2015","journal-title":"Nutrition"},{"key":"key\n\t\t\t\t20180628065747_CIT0004","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.bbapap.2009.11.005","article-title":"Superoxide dismutases - a review of the metal-associated mechanistic variations","volume":"1804","author":"Abreu","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20180628065747_CIT0005","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1107\/S1744309107054127","article-title":"Structure of Bacillus subtilis superoxide dismutase","volume":"63","author":"Liu","year":"2007","journal-title":"Acta Crystallogr Sect F Struct Biol Cryst Commun"},{"key":"key\n\t\t\t\t20180628065747_CIT0006","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/jobm.201300805","article-title":"Effect of heavy metals on growth response and antioxidant defense protection in Bacillus cereus","volume":"54","author":"Behera","year":"2014","journal-title":"J Basic Microbiol"},{"key":"key\n\t\t\t\t20180628065747_CIT0007","first-page":"1033","article-title":"Influence of heavy metals on the activity of antioxidant enzymes in the metal resistant strains of Ochrobactrum and Bacillus sp","volume":"34","author":"Pandey","year":"2013","journal-title":"J Environ Biol"},{"key":"key\n\t\t\t\t20180628065747_CIT0008","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s12602-017-9257-y","article-title":"Erratum to: effect of probiotic Bacillus coagulans and Lactobacillus plantarum on alleviation of mercury toxicity in rat","volume":"9","author":"Majlesi","year":"2017","journal-title":"Probiotics Antimicrob Proteins"},{"key":"key\n\t\t\t\t20180628065747_CIT0009","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jenvrad.2013.09.005","article-title":"Repair effects of exogenous SOD on Bacillus subtilis against gamma radiation exposure","volume":"126","author":"Chen","year":"2013","journal-title":"J Environ Radioact"},{"key":"key\n\t\t\t\t20180628065747_CIT0010","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.fsi.2016.12.003","article-title":"Dietary administration of Bacillus subtilis HAINUP40 enhances growth, digestive enzyme activities, innate immune responses and disease resistance of tilapia, Oreochromis niloticus","volume":"60","author":"Liu","year":"2017","journal-title":"Fish Shellfish Immunol"},{"key":"key\n\t\t\t\t20180628065747_CIT0011","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.fsi.2016.12.035","article-title":"Comparative evaluation of dietary probiotics Bacillus subtilis WB60 and Lactobacillus plantarum KCTC3928 on the growth performance, immunological parameters, gut morphology and disease resistance in Japanese eel, Anguilla japonica","volume":"61","author":"Lee","year":"2017","journal-title":"Fish Shellfish Immunol"},{"key":"key\n\t\t\t\t20180628065747_CIT0012","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.fsi.2013.07.047","article-title":"Combined effects of dietary fructooligosaccharide and Bacillus licheniformis on innate immunity, antioxidant capability and disease resistance of triangular bream [Megalobrama terminalis]","volume":"35","author":"Zhang","year":"2013","journal-title":"Fish Shellfish Immunol"},{"key":"key\n\t\t\t\t20180628065747_CIT0013","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.fsi.2012.06.012","article-title":"Dietary administration of the probiotic, Bacillus subtilis E20, enhances the growth, innate immune responses, and disease resistance of the grouper, Epinephelus coioides","volume":"33","author":"Liu","year":"2012","journal-title":"Fish Shellfish Immunol"},{"key":"key\n\t\t\t\t20180628065747_CIT0014","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3382\/ps\/pew246","article-title":"Supplemental effects of probiotic Bacillus subtilis fmbJ on growth performance, antioxidant capacity, and meat quality of broiler chickens","volume":"96","author":"Bai","year":"2017","journal-title":"Poult Sci"},{"key":"key\n\t\t\t\t20180628065747_CIT0015","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3389\/fmicb.2015.00883","article-title":"Biocontrol agent Bacillus amyloliquefaciens LJ02 induces systemic resistance against cucurbits powdery mildew","volume":"6","author":"Li","year":"2015","journal-title":"Front Microbiol"},{"key":"key\n\t\t\t\t20180628065747_CIT0016","article-title":"Carbohydrase and Protease Enzyme Preparations Derived From Bacillus Subtilis or Bacillus Amyloliquefaciens; Affirmation of Gras Status as Direct Food Ingredients","author":"US Food and Drug Administration"},{"key":"key\n\t\t\t\t20180628065747_CIT0017","first-page":"1","article-title":"Opinion of the scientific committee on a request from EFSA related to a generic approach to the safety assessment by EFSA of microorganisms used in food\/feed and the production of food\/feed additives","volume":"226","author":"EFSA","year":"2005","journal-title":"EFSA J"},{"key":"key\n\t\t\t\t20180628065747_CIT0018","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.fsi.2016.11.016","article-title":"et al. Effects of the dietary supplementation of mixed probiotic spores of Bacillus amyloliquefaciens 54a, and Bacillus pumilus 47b on growth, innate immunity and stress responses of striped catfish [Pangasianodon hypophthalmus]","volume":"60","author":"Truong Thy","year":"2017","journal-title":"Fish Shellfish Immunol"},{"key":"key\n\t\t\t\t20180628065747_CIT0019","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.fsi.2017.05.005","article-title":"Paraprobiotic preparation from Bacillus amyloliquefaciens FPTB16 modulates immune response and immune relevant gene expression in Catla catla [Hamilton, 1822]","volume":"66","author":"Singh","year":"2017","journal-title":"Fish Shellfish Immunol"},{"key":"key\n\t\t\t\t20180628065747_CIT0020","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s00284-014-0717-2","article-title":"Two novel exopolysaccharides from Bacillus amyloliquefaciens c-1: Antioxidation and effect on oxidative stress","volume":"70","author":"Yang","year":"2015","journal-title":"Curr Microbiol"},{"key":"key\n\t\t\t\t20180628065747_CIT0021","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.3382\/ps\/pev124","article-title":"Bacillus amyloliquefaciens supplementation alleviates immunological stress in lipopolysaccharide-challenged broilers at early age","volume":"94","author":"Li","year":"2015","journal-title":"Poult Sci"},{"key":"key\n\t\t\t\t20180628065747_CIT0022","doi-asserted-by":"crossref","first-page":"239","DOI":"10.5713\/ajas.14.0330","article-title":"Effect of Bacillus amyloliquefaciens-based direct-fed microbial on performance, nutrient utilization, intestinal morphology and cecal microflora in broiler chickens","volume":"28","author":"Lei","year":"2015","journal-title":"Asian-Australas J Anim Sci"},{"key":"key\n\t\t\t\t20180628065747_CIT0023","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.3382\/ps.2013-03718","article-title":"Effects of Bacillus amyloliquefaciens as a probiotic strain on growth performance, cecal microflora, and fecal noxious gas emissions of broiler chickens","volume":"93","author":"Ahmed","year":"2014","journal-title":"Poult Sci"},{"key":"key\n\t\t\t\t20180628065747_CIT0024","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1080\/1745039X.2013.830517","article-title":"Effects of dietary supplementation of Bacillus amyloliquefaciens CECT 5940 and Enterococcus faecium CECT 4515 in adult healthy dogs","volume":"67","author":"Gonz\u00e1lez-Ortiz","year":"2013","journal-title":"Arch Anim Nutr"},{"key":"key\n\t\t\t\t20180628065747_CIT0025","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.fsi.2013.08.022","article-title":"Effects of potential probiotic Bacillus amyloliquefaciens [corrected] FPTB16 on systemic and cutaneous mucosal immune responses and disease resistance of catla [Catla catla]","volume":"35","author":"Das","year":"2013","journal-title":"Fish Shellfish Immunol"},{"key":"key\n\t\t\t\t20180628065747_CIT0026","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12602-011-9081-8","article-title":"Isolation and characterization of putative probiotic bacterial strain, Bacillus amyloliquefaciens, from North East Himalayan soil based on in vitro and in vivo functional properties","volume":"3","author":"Hairul Islam","year":"2011","journal-title":"Probiotics Antimicrob Proteins"},{"key":"key\n\t\t\t\t20180628065747_CIT0027","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrgastro.2009.218","article-title":"Future biologic targets for IBD: potentials and pitfalls","volume":"7","author":"Melmed","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20180628065747_CIT0028","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.biomaterials.2016.08.010","article-title":"A superoxide dismutase\/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease","volume":"105","author":"Zhang","year":"2016","journal-title":"Biomaterials"},{"key":"key\n\t\t\t\t20180628065747_CIT0029","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature10209","article-title":"Genetics and pathogenesis of inflammatory bowel disease","volume":"474","author":"Khor","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180628065747_CIT0030","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1007\/BF02093613","article-title":"Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease","volume":"41","author":"Lih-Brody","year":"1996","journal-title":"Dig Dis Sci"},{"key":"key\n\t\t\t\t20180628065747_CIT0031","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s12011-016-0891-0","article-title":"Evaluation of serum trace element levels and superoxide dismutase activity in patients with inflammatory bowel disease: translating basic research into clinical application","volume":"177","author":"Mohammadi","year":"2017","journal-title":"Biol Trace Elem Res"},{"key":"key\n\t\t\t\t20180628065747_CIT0032","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1073\/pnas.1501897112","article-title":"Host lysozyme-mediated lysis of Lactococcus lactis facilitates delivery of colitis-attenuating superoxide dismutase to inflamed colons","volume":"112","author":"Ballal","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180628065747_CIT0033","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/jam.12461","article-title":"Superoxide dismutase recombinant Lactobacillus fermentum ameliorates intestinal oxidative stress through inhibiting NF-\u03baB activation in a trinitrobenzene sulphonic acid-induced colitis mouse model","volume":"116","author":"Hou","year":"2014","journal-title":"J Appl Microbiol"},{"key":"key\n\t\t\t\t20180628065747_CIT0034","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jbiotec.2010.11.008","article-title":"Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn\u2019s disease in mice","volume":"151","author":"LeBlanc","year":"2011","journal-title":"J Biotechnol"},{"key":"key\n\t\t\t\t20180628065747_CIT0035","doi-asserted-by":"crossref","first-page":"G729","DOI":"10.1152\/ajpgi.00132.2007","article-title":"Anti-inflammatory properties of Lactobacillus gasseri expressing manganese superoxide dismutase using the interleukin 10-deficient mouse model of colitis","volume":"293","author":"Carroll","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key\n\t\t\t\t20180628065747_CIT0036","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/01.mib.0000235101.09231.9e","article-title":"Improvement of an experimental colitis in rats by lactic acid bacteria producing superoxide dismutase","volume":"12","author":"Han","year":"2006","journal-title":"Inflamm Bowel Dis"},{"key":"key\n\t\t\t\t20180628065747_CIT0037","doi-asserted-by":"crossref","first-page":"G353; author reply G354","DOI":"10.1152\/ajpgi.00517.2007","article-title":"Anti-inflammatory properties of lactic acid bacteria producing superoxide dismutase","volume":"294","author":"Han","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key\n\t\t\t\t20180628065747_CIT0038","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-1119(96)00404-0","article-title":"Plasmids for ectopic integration in Bacillus subtilis","volume":"180","author":"Gu\u00e9rout-Fleury","year":"1996","journal-title":"Gene"},{"key":"key\n\t\t\t\t20180628065747_CIT0039","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1128\/jb.176.6.1761-1763.1994","article-title":"Easy cloning of mini-Tn10 insertions from the Bacillus subtilis chromosome","volume":"176","author":"Steinmetz","year":"1994","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180628065747_CIT0040","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ab.2010.10.013","article-title":"Enhancing electro-transformation competency of recalcitrant Bacillus amyloliquefaciens by combining cell-wall weakening and cell-membrane fluidity disturbing","volume":"409","author":"Zhang","year":"2011","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20180628065747_CIT0041","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0027-5107(81)90154-8","article-title":"UV-induced mutation fixation in Bacillus subtilis","volume":"82","author":"Filippov","year":"1981","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20180628065747_CIT0042","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00284-012-0269-2","article-title":"Bacillus subtilis endospores at high purity and recovery yields: optimization of growth conditions and purification method","volume":"66","author":"Tavares","year":"2013","journal-title":"Curr Microbiol"},{"key":"key\n\t\t\t\t20180628065747_CIT0043","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1002\/ibd.20951","article-title":"Role of TNF receptors, TNFR1 and TNFR2, in dextran sodium sulfate-induced colitis","volume":"15","author":"Stillie","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"key\n\t\t\t\t20180628065747_CIT0044","doi-asserted-by":"crossref","first-page":"D190","DOI":"10.1093\/nar\/gkw1107","article-title":"InterPro in 2017-beyond protein family and domain annotations","volume":"45","author":"Finn","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20180628065747_CIT0045","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/pmic.200800483","article-title":"MscL of Bacillus subtilis prevents selective release of cytoplasmic proteins in a hypotonic environment","volume":"9","author":"Kouwen","year":"2009","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20180628065747_CIT0046","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/0471973165.ch12","article-title":"Proteomic survey through secretome of Bacillus subtilis","volume":"49","author":"Antelmann","year":"2006","journal-title":"Methods Biochem Anal"},{"key":"key\n\t\t\t\t20180628065747_CIT0047","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.3390\/nu7031565","article-title":"Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity","volume":"7","author":"Hollon","year":"2015","journal-title":"Nutrients"},{"key":"key\n\t\t\t\t20180628065747_CIT0048","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/00365520500235334","article-title":"Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines","volume":"41","author":"Drago","year":"2006","journal-title":"Scand J Gastroenterol"},{"key":"key\n\t\t\t\t20180628065747_CIT0049","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3389\/fmicb.2017.00800","article-title":"Use of wild type or recombinant lactic acid bacteria as an alternative treatment for gastrointestinal inflammatory diseases: a focus on inflammatory bowel diseases and mucositis","volume":"8","author":"Carvalho","year":"2017","journal-title":"Front Microbiol"},{"key":"key\n\t\t\t\t20180628065747_CIT0050","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00210-014-0985-1","article-title":"Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases","volume":"387","author":"Piechota-Polanczyk","year":"2014","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"key\n\t\t\t\t20180628065747_CIT0051","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1128\/JB.188.7.2692-2700.2006","article-title":"The intestinal life cycle of Bacillus subtilis and close relatives","volume":"188","author":"Tam","year":"2006","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180628065747_CIT0052","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.3945\/jn.109.108613","article-title":"Bacillus polyfermenticus ameliorates colonic inflammation by promoting cytoprotective effects in colitic mice","volume":"139","author":"Im","year":"2009","journal-title":"J Nutr"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/12\/7\/860\/25077679\/jjy034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T16:08:09Z","timestamp":1693584489000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/12\/7\/860\/4935132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,14]]},"references-count":52,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,3,14]]},"published-print":{"date-parts":[[2018,6,28]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjy034","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,7]]},"published":{"date-parts":[[2018,3,14]]}}}