{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:45:21Z","timestamp":1790725521879,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"vor","delay-in-days":62,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Zurich Center for Integrative Human Physiology"},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["310030_172870"],"award-info":[{"award-number":["310030_172870"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["314730_153380"],"award-info":[{"award-number":["314730_153380"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["33CS30_148422"],"award-info":[{"award-number":["33CS30_148422"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swiss IBD Cohort"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"DOI":"10.1093\/ecco-jcc\/jjy152","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T18:40:08Z","timestamp":1540492808000},"page":"245-258","source":"Crossref","is-referenced-by-count":54,"title":["Lack of the pH-sensing Receptor TDAG8 [GPR65] in Macrophages Plays a Detrimental Role in Murine Models of Inflammatory Bowel Disease"],"prefix":"10.1093","volume":"13","author":[{"given":"Irina","family":"Tcymbarevich","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shola M","family":"Richards","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Russo","sequence":"additional","affiliation":[{"name":"Functional Genomics Center Zurich, ETH Zurich\/University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"K\u00fchn-Georgijevic","sequence":"additional","affiliation":[{"name":"Functional Genomics Center Zurich, ETH Zurich\/University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Cosin-Roger","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Baebler","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Bengs","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstin","family":"Atrott","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Bettoni","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"},{"name":"Institute of Physiology, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Frey-Wagner","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Scharl","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"},{"name":"Zurich Center for Integrative Human Physiology, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Misselwitz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9874-8898","authenticated-orcid":false,"given":"Carsten A","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Zurich, Switzerland"},{"name":"Zurich Center for Integrative Human Physiology, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Seuwen","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Rogler","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"},{"name":"Zurich Center for Integrative Human Physiology, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Spalinger","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"de Valli\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Z\u00fcrich, University of Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"key\n\t\t\t\t2019020109393418600_CIT0001","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature01905","article-title":"Proton-sensing G-protein-coupled receptors","volume":"425","author":"Ludwig","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0002","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/10799890600932220","article-title":"Receptors for protons or lipid messengers or both","volume":"26","author":"Seuwen","year":"2006","journal-title":"J Recept Signal Transduct Res"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0003","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.cellsig.2013.07.022","article-title":"Regulation of inflammation by extracellular acidification and proton-sensing GPCRs","volume":"25","author":"Okajima","year":"2013","journal-title":"Cell Signal"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0004","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ejphar.2011.01.005","article-title":"Activation of T cell death-associated gene 8 attenuates inflammation by negatively regulating the function of inflammatory cells","volume":"654","author":"Onozawa","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0005","doi-asserted-by":"crossref","first-page":"17309","DOI":"10.1073\/pnas.1001165107","article-title":"The G protein-coupled receptor T-cell death-associated gene 8 [TDAG8] facilitates tumor development by serving as an extracellular pH sensor","volume":"107","author":"Ihara","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0006","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1038\/sj.onc.1207838","article-title":"G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers","volume":"23","author":"Sin","year":"2004","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0007","doi-asserted-by":"crossref","first-page":"45626","DOI":"10.1074\/jbc.M406966200","article-title":"TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor","volume":"279","author":"Wang","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0008","doi-asserted-by":"crossref","first-page":"9083","DOI":"10.1074\/jbc.M407832200","article-title":"Identification of T cell death-associated gene 8 [TDAG8] as a novel acid sensing G-protein-coupled receptor","volume":"280","author":"Ishii","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0009","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.4049\/jimmunol.0803466","article-title":"Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages","volume":"182","author":"Mogi","year":"2009","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0010","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.cellsig.2005.06.002","article-title":"Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: a novel type of multi-functional receptors","volume":"17","author":"Tomura","year":"2005","journal-title":"Cell Signal"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0011","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-immunol-051116-052235","article-title":"Metabolite-sensing G protein-coupled receptors-facilitators of diet-related immune regulation","volume":"35","author":"Tan","year":"2017","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0012","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jcmgh.2016.06.003","article-title":"Hypoxia positively regulates the expression of pH-sensing G-protein-coupled receptor OGR1 [GPR68]","volume":"2","author":"de Valli\u00e8re","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0013","doi-asserted-by":"crossref","first-page":"G475","DOI":"10.1152\/ajpgi.00408.2014","article-title":"The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment","volume":"309","author":"de Valli\u00e8re","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0014","first-page":"1269","article-title":"G protein-coupled pH-sensing receptor OGR1 is a regulator of intestinal inflammation","volume":"21","author":"de Valli\u00e8re","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0015","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/ecco-jcc\/jjx147","article-title":"The proton-activated receptor GPR4 modulates intestinal inflammation","volume":"12","author":"Wang","year":"2018","journal-title":"J Crohns Colitis"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0016","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ng.717","article-title":"Genome-wide meta-analysis increases to 71 the number of confirmed Crohn\u2019s disease susceptibility loci","volume":"42","author":"Franke","year":"2010","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0017","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"Jostins","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0018","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.cell.2015.11.009","article-title":"Single-cell genomics unveils critical regulators of Th17 cell pathogenicity","volume":"163","author":"Gaublomme","year":"2015","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0019","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cell.2012.09.016","article-title":"A validated regulatory network for Th17 cell specification","volume":"151","author":"Ciofani","year":"2012","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0020","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.immuni.2016.05.007","article-title":"Genetic coding variant in GPR65 alters lysosomal pH and links lysosomal dysfunction with colitis risk","volume":"44","author":"Lassen","year":"2016","journal-title":"Immunity"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0021","doi-asserted-by":"crossref","first-page":"52, 54","DOI":"10.2144\/00291bm09","article-title":"Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris [HotSHOT]","volume":"29","author":"Truett","year":"2000","journal-title":"Biotechniques"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0022","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/gut.2009.201988","article-title":"Sphingomyelin induces cathepsin D-mediated apoptosis in intestinal epithelial cells and increases inflammation in DSS colitis","volume":"60","author":"Fischbeck","year":"2011","journal-title":"Gut"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0023","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000327380","article-title":"Knock-out of \u03b2-glucosidase 2 has no influence on dextran sulfate sodium-induced colitis","volume":"84","author":"Scharl","year":"2011","journal-title":"Digestion"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0024","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2249.2007.03350.x","article-title":"In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium-induced colitis","volume":"148","author":"Hausmann","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0025","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0026","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/mi.2014.122","article-title":"PTPN2 controls differentiation of CD4\u207a T cells and limits intestinal inflammation and intestinal dysbiosis","volume":"8","author":"Spalinger","year":"2015","journal-title":"Mucosal Immunol"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0027","first-page":"Unit 14.1","article-title":"The isolation and characterization of murine macrophages","volume":"Chapter 14","author":"Zhang","year":"2008","journal-title":"Curr Protoc Immunol"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0028","volume-title":"SPSS Statistics for Windows VCSI","author":"SPSS Inc","year":"2008"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0029","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1038\/emboj.2012.231","article-title":"E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1","volume":"31","author":"Weijts","year":"2012","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0030","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.celrep.2015.04.047","article-title":"DDX60 is involved in RIG-I-dependent and independent antiviral responses, and its function is attenuated by virus-induced EGFR activation","volume":"11","author":"Oshiumi","year":"2015","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0031","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1189\/jlb.2A1216-526R","article-title":"Up-regulation of EP2 and EP3 receptors in human tolerogenic dendritic cells boosts the immunosuppressive activity of PGE2","volume":"102","author":"Fl\u00f3rez-Grau","year":"2017","journal-title":"J Leukoc Biol"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0032","doi-asserted-by":"crossref","first-page":"608930","DOI":"10.1155\/2014\/608930","article-title":"Cysteinyl leukotriene receptor-1 antagonists as modulators of innate immune cell function","volume":"2014","author":"Theron","year":"2014","journal-title":"J Immunol Res"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0033","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1182\/blood-2014-06-582965","article-title":"TOX2 regulates human natural killer cell development by controlling T-BET expression","volume":"124","author":"Vong","year":"2014","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0034","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.cell.2012.04.046","article-title":"Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration","volume":"149","author":"Wu","year":"2012","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0035","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","article-title":"Nitric oxide and macrophage function","volume":"15","author":"MacMicking","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0036","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1471-4159.2008.05862.x","article-title":"Signaling mechanisms of interferon gamma induced apoptosis in chromaffin cells: involvement of nNOS, iNOS, and NFkappaB","volume":"108","author":"P\u00e9rez-Rodr\u00edguez","year":"2009","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0037","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J Leukoc Biol"},{"key":"key\n\t\t\t\t2019020109393418600_CIT0038","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ejphar.2012.03.007","article-title":"Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro","volume":"683","author":"Onozawa","year":"2012","journal-title":"Eur J Pharmacol"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/13\/2\/245\/27692965\/jjy152.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T07:31:02Z","timestamp":1572247862000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/13\/2\/245\/5237755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,10,9]]},"published-print":{"date-parts":[[2019,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjy152","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,2]]},"published":{"date-parts":[[2018,10,9]]}}}