{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T21:32:55Z","timestamp":1794346375063,"version":"4.9.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001729","name":"Swedish Foundation for Strategic Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Olle Engkvist Byggm\u00e4stare foundation"},{"DOI":"10.13039\/501100009336","name":"Bengt Ihres Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Swedish Medical Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,26]]},"DOI":"10.1093\/ecco-jcc\/jjy170","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T11:18:16Z","timestamp":1539602296000},"page":"341-350","source":"Crossref","is-referenced-by-count":13,"title":["High Serum sCD40 and a Distinct Colonic T Cell Profile in Ulcerative Colitis Associated With Primary Sclerosing Cholangitis"],"prefix":"10.1093","volume":"13","author":[{"given":"Maria","family":"Lampinen","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Gastroenterology Research Group, University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Vessby","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Gastroenterology Research Group, University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Fredricsson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Gastroenterology Research Group, University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alkwin","family":"Wanders","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Rorsman","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Gastroenterology Research Group, University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Gastroenterology Research Group, University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,20]]},"reference":[{"key":"key\n\t\t\t\t2019032608503096500_CIT0001","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1055\/s-2008-1040420","article-title":"Relationship of inflammatory bowel disease and primary sclerosing cholangitis","volume":"11","author":"Fausa","year":"1991","journal-title":"Semin Liver Dis"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0002","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1016\/S0140-6736(18)30300-3","article-title":"Primary sclerosing cholangitis","volume":"391","author":"Dyson","year":"2018","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0003","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/gut.2004.046615","article-title":"PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis","volume":"54","author":"Loftus","year":"2005","journal-title":"Gut"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0004","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s00534-010-0319-8","article-title":"Clinical characteristics of inflammatory bowel disease associated with primary sclerosing cholangitis","volume":"18","author":"Sano","year":"2011","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0005","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/S0140-6736(13)60096-3","article-title":"Primary sclerosing cholangitis","volume":"382","author":"Hirschfield","year":"2013","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0006","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1002\/hep.24570","article-title":"Cancer surveillance in patients with primary sclerosing cholangitis","volume":"54","author":"Razumilava","year":"2011","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0007","first-page":"279","article-title":"A case series of transplant recipients who despite immunosuppression developed inflammatory bowel disease","volume":"92","author":"Riley","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0008","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0140-6736(02)07374-9","article-title":"Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease","volume":"359","author":"Grant","year":"2002","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0009","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1084\/jem.20041035","article-title":"Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis","volume":"200","author":"Eksteen","year":"2004","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0010","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/ecco-jcc\/jjx050","article-title":"Th1 and innate lymphoid cells accumulate in primary sclerosing cholangitis-associated inflammatory bowel disease","volume":"11","author":"Gwela","year":"2017","journal-title":"J Crohns Colitis"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0011","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/JLB.3MA0517-175R","article-title":"Downregulated eosinophil activity in ulcerative colitis with concomitant primary sclerosing cholangitis","volume":"104","author":"Lampinen","year":"2018","journal-title":"J Leukoc Biol"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0012","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1002\/ibd.22938","article-title":"Primary sclerosing cholangitis is associated with a distinct phenotype of inflammatory bowel disease","volume":"18","author":"Boonstra","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0013","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1053\/j.gastro.2017.02.038","article-title":"Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis","volume":"152","author":"Weism\u00fcller","year":"2017","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0014","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1053\/j.gastro.2004.02.072","article-title":"From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation","volume":"126","author":"Sands","year":"2004","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0015","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1074\/mcp.M116.064725","article-title":"Tracing cellular origin of human exosomes using multiplex proximity extension assays","volume":"16","author":"Larssen","year":"2017","journal-title":"Mol Cell Proteomics"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0016","doi-asserted-by":"crossref","first-page":"3958069","DOI":"10.1155\/2017\/3958069","article-title":"Dual roles of IL-27 in cancer biology and immunotherapy","volume":"2017","author":"Fabbi","year":"2017","journal-title":"Mediators Inflamm"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0017","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1136\/gut.2005.066423","article-title":"Eosinophil granulocytes are activated during the remission phase of ulcerative colitis","volume":"54","author":"Lampinen","year":"2005","journal-title":"Gut"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0018","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/(SICI)1097-0320(19970101)27:1<71::AID-CYTO9>3.0.CO;2-O","article-title":"Flow cytometric analysis of activation markers on stimulated T cells and their correlation with cell proliferation","volume":"27","author":"Caruso","year":"1997","journal-title":"Cytometry"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0019","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.yexcr.2010.12.017","article-title":"CXCR3 in T cell function","volume":"317","author":"Groom","year":"2011","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0020","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1002\/1521-4141(200010)30:10<2972::AID-IMMU2972>3.0.CO;2-#","article-title":"CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease","volume":"30","author":"Cosmi","year":"2000","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0021","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1067\/mai.2001.112266","article-title":"Inflammatory cell and epithelial characteristics of perennial allergic and nonallergic rhinitis with a symptom history of 1 to 3 years\u2019 duration","volume":"107","author":"Amin","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0022","doi-asserted-by":"crossref","first-page":"941","DOI":"10.2307\/2532216","article-title":"On adjusting P-values for multiplicity","volume":"49","author":"Westfall","year":"1993","journal-title":"Biometrics"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0023","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1023\/B:APPT.0000018802.95600.25","article-title":"Role of circulating soluble CD40 as an apoptotic marker in liver disease","volume":"9","author":"Schmilovitz-Weiss","year":"2004","journal-title":"Apoptosis"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0024","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.2353\/ajpath.2010.090461","article-title":"The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease","volume":"176","author":"Borcherding","year":"2010","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0025","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1111\/j.1572-0241.2000.01938.x","article-title":"An increased number of CD40-high monocytes in patients with Crohn\u2019s disease","volume":"95","author":"Sawada-Hase","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0026","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1136\/gut.52.10.1435","article-title":"Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients","volume":"52","author":"Danese","year":"2003","journal-title":"Gut"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0027","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0002-9440(10)62060-3","article-title":"CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow","volume":"167","author":"Curbishley","year":"2005","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0028","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1053\/jhep.2001.24231","article-title":"MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium [MAdCAM-1 in chronic inflammatory liver disease]","volume":"33","author":"Grant","year":"2001","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0029","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00281-009-0167-2","article-title":"Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis","volume":"31","author":"Borchers","year":"2009","journal-title":"Semin Immunopathol"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0030","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1136\/gut.49.1.131","article-title":"Tumour necrosis factor alpha impairs function of liver derived T lymphocytes and natural killer cells in patients with primary sclerosing cholangitis","volume":"49","author":"Bo","year":"2001","journal-title":"Gut"},{"key":"key\n\t\t\t\t2019032608503096500_CIT0031","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jhep.2013.12.027","article-title":"Reduced FOXP3[+] regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms","volume":"60","author":"Sebode","year":"2014","journal-title":"J Hepatol"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/13\/3\/341\/28222390\/jjy170.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T07:13:40Z","timestamp":1589958820000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/13\/3\/341\/5139660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,20]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,10,20]]},"published-print":{"date-parts":[[2019,3,26]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjy170","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3]]},"published":{"date-parts":[[2018,10,20]]}}}