{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:00:23Z","timestamp":1785344423827,"version":"3.55.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Standard high-volume polyethylene glycol [PEG] bowel preparations [PEG-4L] are recommended for patients with inflammatory bowel disease [IBD] undergoing colonoscopy. However, low-volume preparations [\u22642 L of active volume] are often used in clinical practice. The aim of this study was to evaluate the efficacy, tolerability, and safety of the various bowel preparations for patients with IBD, including low-volume preparations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a French prospective multicentre observational study over a period of 1 month. Patients aged 18\u201375 years with IBD with an indication of colonoscopy independent of the study were enrolled. The choice of the preparation was left to the investigators, as per their usual protocol. The patients\u2019 characteristics, disease, and colonoscopy characteristics were recorded, and they were given self-reported questionnaires.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-five public and private hospitals enrolled 278 patients. Among them, 46 had a disease flare and 41 had bowel stenoses. Bowel preparations for colonoscopy were as follows: 42% received PEG-2L, 29% received sodium picosulfate [Pico], 15% received PEG-4L, and 14% had other preparations. The preparation did not reach the Boston\u2019s score efficacy outcome in the PEG-4L group in 51.2% of the patients [p = 0.0011]. The preparation intake was complete for 59.5% in the PEG-4L group, compared with 82.9% in the PEG-2L group and 93.8% in the Pico group [p &amp;lt; 0.0001]. Tolerability, as assessed by the patients\u2019 VAS, was significantly better for both Pico and PEG-2L compared with PEG-4L, and better for Pico compared with PEG-2L [p = 0.008; p = 0.0003]. In multivariate analyses, low-volume preparations were independent factors of efficacy and tolerability. Adverse events occurred in 4.3% of the patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Preparations with PEG-2L and Pico were equally safe, with better efficacy and tolerability outcomes compared with PEG-4L preparations. The best efficacy\/tolerance\/safety profile was achieved with the Pico preparation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjz040","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T04:24:23Z","timestamp":1550463863000},"page":"1121-1130","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy, Tolerability, and Safety of Low-Volume Bowel Preparations for Patients with Inflammatory Bowel Diseases: The French Multicentre CLEAN Study"],"prefix":"10.1093","volume":"13","author":[{"given":"C","family":"Briot","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, University Hospital of Besan\u00e7on, University Bourgogne Franche-Comt\u00e9, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Faure","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Clinique Pasteur, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A L","family":"Parmentier","sequence":"additional","affiliation":[{"name":"Centre de M\u00e9thodologie Clinique, University Hospital of Besan\u00e7on, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Nachury","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University Hospital of Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Trang","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology, University Hospital Hotel Dieu, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Viennot","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University Hospital of Caen, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Altwegg","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology, University Hospital of St Eloi, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Bulois","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, H\u00f4pital Priv\u00e9 la Louvi\u00e8re, Ramsay G\u00e9n\u00e9rale de Sant\u00e9, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Thomassin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Charles Nicolle, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Serrero","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, APHM, Hopital Nord, Marseille, 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Filippi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital L\u2019Archet, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Amiot","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Henri Mondor Hospital, APHP, Creteil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Attar","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Beaujon University Hospital, Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Clinique des C\u00e8dres, Cornebarrieu, 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