{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:15:24Z","timestamp":1793103324436,"version":"4.5.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Primary sclerosing cholangitis [PSC] is usually associated with inflammatory bowel disease [IBD]. An increased risk of malignancies, mainly colorectal cancer [CRC] and cholangiocarcinoma [CCA], has been reported in PSC-IBD patients. Our aim was to determine the clinical characteristics and management of PSC in IBD patients, and the factors associated with malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PSC-IBD patients were identified from the Spanish ENEIDA registry of GETECCU. Additional data were collected using the AEG-REDCap electronic data capture tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 277 PSC-IBD patients were included, with an incidence rate of 61 PSC cases per 100 000 IBD patient-years, 69.7% men, 67.5% ulcerative colitis and mean age at PSC diagnosis of 40 \u00b1 16 years. Most patients [85.2%] were treated with ursodeoxycholic acid. Liver transplantation was required in 35 patients [12.6%] after 79 months (interquartile range [IQR] 50\u2013139). It was more common in intra- and extrahepatic PSC compared with small-duct PSC (16.3% vs 3.3%; odds ratio [OR] 5.7: 95% confidence interval [CI] = 1.7\u201319.3). The incidence rate of CRC since PSC diagnosis was 3.3 cases per 1000 patient-years [95% CI = 1.9\u20135.6]. Having symptoms of PSC at PSC diagnosis was the only factor related to an increased risk of CRC after IBD diagnosis [hazard ratio= 3.3: 95% CI = 1.1\u20139.9]. CCA was detected in seven patients [2.5%] with intra- and extrahepatic PSC, with median age of 42 years [IQR 39\u201353], and presented a lower life expectancy compared with patients without CCA and patients with or without CRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PSC-IBD patients with symptoms of PSC at PSC diagnosis have an increased risk of CRC. CCA was only diagnosed in patients with intra- and extrahepatic PSC and was associated with poor survival.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjz094","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T15:27:52Z","timestamp":1557156472000},"page":"1492-1500","source":"Crossref","is-referenced-by-count":50,"title":["Clinical Characteristics, Associated Malignancies and Management of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients: A Multicentre Retrospective Cohort Study"],"prefix":"10.1093","volume":"13","author":[{"given":"Ivan","family":"Guerra","sequence":"first","affiliation":[{"name":"Hospital Universitario de Fuenlabrada and Instituto de Investigaci\u00f3n del Hospital Universitario La Paz, IdiPaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Bujanda","sequence":"additional","affiliation":[{"name":"Hospital Donostia\/Instituto Biodonostia, Universidad del Pa\u00eds Vasco UPV\/EHU, Donostia-San Sebasti\u00e1n, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Castro","sequence":"additional","affiliation":[{"name":"Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Merino","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Cruces, Barakaldo, Vizcaya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Tosca","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cl\u00ednico de Valencia, Department of Medicine, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blau","family":"Camps","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), l\u2019Hospitalet de Llobregat, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Spain"},{"name":"Hospital General Universitario de Alicante, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Gordillo \u00c1balos","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"de Castro","sequence":"additional","affiliation":[{"name":"Complexo Hospitalario Universitario de Vigo, Instituto de Investigaci\u00f3n Biom\u00e9dica. Estructura Organizativa de Xesti\u00f3n Integrada de Vigo, Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Iborra","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Spain"},{"name":"Hospital Universitario y Polit\u00e9cnico de La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Y","family":"Carbajo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Rio Hortega, Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Taxonera","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos and Instituto de Investigaci\u00f3n del Hospital Cl\u00ednico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iago","family":"Rodr\u00edguez-Lago","sequence":"additional","affiliation":[{"name":"Hospital de Galdakao, Galdakao, Vizcaya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mesonero","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"de Francisco","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central De Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo J","family":"G\u00f3mez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Hospital 12 de Octubre, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Chaparro","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Spain"},{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP), Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A","family":"Tardillo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Nuestra Se\u00f1ora Candelaria, Santa Cruz De Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Rivero","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla and IDIVAL, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Algaba","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Fuenlabrada and Instituto de Investigaci\u00f3n del Hospital Universitario La Paz, IdiPaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Mart\u00edn Arranz","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz and Instituto de Investigaci\u00f3n del Hospital Universitario La Paz, IdiPaz, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorella","family":"Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Spain"},{"name":"Hospital Universitari Germans Trias i Pujol, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Vicente","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Sicilia","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Burgos, Burgos, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Antol\u00edn","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Prieto","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Parc de Salut Mar, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M","family":"Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda and Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC), C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Camo","sequence":"additional","affiliation":[{"name":"Hospital General San Jorge, Huesca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Piqueras","sequence":"additional","affiliation":[{"name":"Consorci Sanitari Terrassa, Terrassa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla J","family":"Gargallo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario \u201cLozano Blesa\u201d and Arag\u00f3n Health Research Institute (IIS Arag\u00f3n), Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Hinojosa","sequence":"additional","affiliation":[{"name":"Hospital de Manises, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M","family":"Huguet","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L","family":"P\u00e9rez Calle","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Van Domselaar","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Torrej\u00f3n and Universidad Francisco de Vitoria, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Complejo hospitalario de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Calvet","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Spain"},{"name":"Corporaci\u00f3 Sanit\u00e0ria Universit\u00e0ria Parc Taul\u00ed, Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mu\u00f1oz-Villafranca","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Basurto, Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana F","family":"Garc\u00eda-Sepulcre","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Elche, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Munoz-Garrido","sequence":"additional","affiliation":[{"name":"Hospital Donostia\/Instituto Biodonostia, Universidad del Pa\u00eds Vasco UPV\/EHU, Donostia-San Sebasti\u00e1n, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Fern\u00e1ndez-Clotet","sequence":"additional","affiliation":[{"name":"Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"G\u00f3mez Irwin","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Cruces, Barakaldo, Vizcaya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherly","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cl\u00ednico de Valencia, Department of Medicine, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Guardiola","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), l\u2019Hospitalet de Llobregat, Spain"},{"name":"Universitat de Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sempere","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Alicante, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gonz\u00e1lez Mu\u00f1oza","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicent","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Complexo Hospitalario Universitario de Vigo, Instituto de Investigaci\u00f3n Biom\u00e9dica. Estructura Organizativa de Xesti\u00f3n Integrada de Vigo, Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Spain"},{"name":"Hospital Universitario y Polit\u00e9cnico de La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Barrio","sequence":"additional","affiliation":[{"name":"Hospital Universitario Rio Hortega, Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Alba","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos and Instituto de Investigaci\u00f3n del Hospital Cl\u00ednico San Carlos (IdISSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Moraleja","sequence":"additional","affiliation":[{"name":"Hospital de Galdakao, Galdakao, Vizcaya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"L\u00f3pez-Sanrom\u00e1n","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabino","family":"Riestra","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central De Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Mart\u00ednez Montiel","sequence":"additional","affiliation":[{"name":"Hospital 12 de Octubre, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garre","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Spain"},{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP), Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Arranz","sequence":"additional","affiliation":[{"name":"Hospital Universitario Nuestra Se\u00f1ora Candelaria, Santa Cruz De Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-7005","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla and IDIVAL, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Mart\u00edn Arranz","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz and Instituto de Investigaci\u00f3n del Hospital Universitario La Paz, IdiPaz, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Corsino","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Arias","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Burgos, Burgos, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Fern\u00e1ndez-Salazar","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Fern\u00e1ndez-Pordomingo","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Andreu","sequence":"additional","affiliation":[{"name":"Parc de Salut Mar, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda and Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC), C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Ber","sequence":"additional","affiliation":[{"name":"Hospital General San Jorge, Huesca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Mena","sequence":"additional","affiliation":[{"name":"Consorci Sanitari Terrassa, Terrassa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Arroyo Villarino","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario \u201cLozano Blesa\u201d and Arag\u00f3n Health Research Institute (IIS Arag\u00f3n), Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Mora","sequence":"additional","affiliation":[{"name":"Hospital de Manises, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"L\u00f3pez-Serrano","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Blazquez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Torrej\u00f3n and Universidad Francisco de Vitoria, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Villoria","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Spain"},{"name":"Complejo hospitalario de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Corporaci\u00f3 Sanit\u00e0ria Universit\u00e0ria Parc Taul\u00ed, Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Bermejo","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Fuenlabrada and Instituto de Investigaci\u00f3n del Hospital Universitario La Paz, IdiPaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus M","family":"Banales","sequence":"additional","affiliation":[{"name":"Hospital Donostia\/Instituto Biodonostia, Universidad del Pa\u00eds Vasco UPV\/EHU, Donostia-San Sebasti\u00e1n, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Spain"},{"name":"Ikerbasque (Basque Foundation for Sciencies), Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeni","family":"Dom\u00e8nech","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Spain"},{"name":"Hospital Universitari Germans Trias i Pujol, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier P","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Spain"},{"name":"Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-IP), Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Spanish GETECCU group (ENEIDA Project)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"2019121011173480400_CIT0001","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1002\/hep.24247","article-title":"Incidence of primary sclerosing cholangitis: a systematic review and meta-analysis","volume":"53","author":"Molodecky","year":"2011","journal-title":"Hepatology"},{"key":"2019121011173480400_CIT0002","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.gastro.2003.07.011","article-title":"Incidence, clinical spectrum, and outcomes of primary sclerosing cholangitis in a United States community","volume":"125","author":"Bambha","year":"2003","journal-title":"Gastroenterology"},{"key":"2019121011173480400_CIT0003","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/hep.23678","article-title":"Incidence and prevalence of primary sclerosing cholangitis in a defined adult population in Sweden","volume":"52","author":"Lindkvist","year":"2010","journal-title":"Hepatology"},{"key":"2019121011173480400_CIT0004","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1055\/s-2008-1040420","article-title":"Relationship of inflammatory bowel disease and primary sclerosing cholangitis","volume":"11","author":"Fausa","year":"1991","journal-title":"Semin Liver Dis"},{"key":"2019121011173480400_CIT0005","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.cld.2017.06.004","article-title":"Primary sclerosing cholangitis: what the gastroenterologist and hepatologist needs to know","volume":"21","author":"Gossard","year":"2017","journal-title":"Clin Liver Dis"},{"key":"2019121011173480400_CIT0006","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1053\/bega.2001.0204","article-title":"Epidemiology of primary sclerosing cholangitis","volume":"15","author":"Schrumpf","year":"2001","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"2019121011173480400_CIT0007","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/ng.3745","article-title":"Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease","volume":"49","author":"Ji","year":"2017","journal-title":"Nat Genet"},{"key":"2019121011173480400_CIT0008","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0168-8278(01)00288-4","article-title":"Hepatic and extrahepatic malignancies in primary sclerosing cholangitis","volume":"36","author":"Bergquist","year":"2002","journal-title":"J Hepatol"},{"key":"2019121011173480400_CIT0009","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1053\/jhep.2002.31872","article-title":"Time-dependent Cox regression model is superior in prediction of prognosis in primary sclerosing cholangitis","volume":"35","author":"Boberg","year":"2002","journal-title":"Hepatology"},{"key":"2019121011173480400_CIT0010","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1136\/flgastro-2017-100815","article-title":"Primary sclerosing cholangitis and the management of uncertainty and complexity","volume":"8","author":"Arndtz","year":"2017","journal-title":"Frontline Gastroenterol"},{"key":"2019121011173480400_CIT0011","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1053\/j.gastro.2009.11.046","article-title":"Genome-wide association analysis in primary sclerosing cholangitis","volume":"138","author":"Karlsen","year":"2010","journal-title":"Gastroenterology"},{"key":"2019121011173480400_CIT0012","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/ecco-jcc\/jjv213","article-title":"The First European Evidence-based Consensus on extra-intestinal manifestations in inflammatory bowel disease","volume":"10","author":"Harbord","year":"2016","journal-title":"J Crohns Colitis"},{"key":"2019121011173480400_CIT0013","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1053\/j.gastro.2010.10.014","article-title":"Bone disease in patients with primary sclerosing cholangitis","volume":"140","author":"Angulo","year":"2011","journal-title":"Gastroenterology"},{"key":"2019121011173480400_CIT0014","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jhep.2009.04.009","article-title":"EASL clinical practice guidelines: management of cholestatic liver diseases","volume":"51","author":"European Association for the Study of the Liver","year":"2009","journal-title":"J Hepatol"},{"key":"2019121011173480400_CIT0015","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/MEG.0000000000000576","article-title":"Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and inflammatory bowel disease: a meta-analysis of 16 observational studies","volume":"28","author":"Zheng","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2019121011173480400_CIT0016","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1002\/hep.24570","article-title":"Cancer surveillance in patients with primary sclerosing cholangitis","volume":"54","author":"Razumilava","year":"2011","journal-title":"Hepatology"},{"key":"2019121011173480400_CIT0017","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1136\/gutjnl-2016-312137","article-title":"Primary sclerosing cholangitis: 50 years of a gut-liver relationship and still no love?","volume":"65","author":"Karlsen","year":"2016","journal-title":"Gut"},{"key":"2019121011173480400_CIT0018","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/hep.23294","article-title":"Diagnosis and management of primary sclerosing cholangitis","volume":"51","author":"Chapman","year":"2010","journal-title":"Hepatology"},{"key":"2019121011173480400_CIT0019","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/ajg.2015.112","article-title":"ACG clinical guideline: primary sclerosing cholangitis","volume":"110","author":"Lindor","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"2019121011173480400_CIT0020","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2013a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"2019121011173480400_CIT0021","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1053\/j.gastro.2016.06.021","article-title":"Prevalence of sclerosing cholangitis detected by magnetic resonance cholangiography in patients with long-term inflammatory bowel disease","volume":"151","author":"Lunder","year":"2016","journal-title":"Gastroenterology"},{"key":"2019121011173480400_CIT0022","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000440705","article-title":"Worldwide incidence of autoimmune liver disease","volume":"33","author":"Jepsen","year":"2015","journal-title":"Dig Dis"},{"key":"2019121011173480400_CIT0023","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/liv.13548","article-title":"Inflammatory bowel disease with primary sclerosing cholangitis: a Danish population-based cohort study 1977-2011","volume":"38","author":"S\u00f8rensen","year":"2018","journal-title":"Liver Int"},{"key":"2019121011173480400_CIT0024","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1016\/S0140-6736(18)30300-3","article-title":"Primary sclerosing cholangitis","volume":"391","author":"Dyson","year":"2018","journal-title":"Lancet"},{"key":"2019121011173480400_CIT0025","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1002\/ibd.22938","article-title":"Primary sclerosing cholangitis is associated with a distinct phenotype of inflammatory bowel disease","volume":"18","author":"Boonstra","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"2019121011173480400_CIT0026","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1007\/s10620-013-2697-7","article-title":"The phenotypic expression of inflammatory bowel disease in patients with primary sclerosing cholangitis differs in the distribution of colitis","volume":"58","author":"Schaeffer","year":"2013","journal-title":"Dig Dis Sci"},{"key":"2019121011173480400_CIT0027","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.crohns.2014.01.019","article-title":"Mortality and extraintestinal cancers in patients with primary sclerosing cholangitis and inflammatory bowel disease","volume":"8","author":"Ananthakrishnan","year":"2014","journal-title":"J Crohns Colitis"},{"key":"2019121011173480400_CIT0028","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1111\/liv.12492","article-title":"Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease","volume":"34","author":"Naess","year":"2014","journal-title":"Liver Int"},{"key":"2019121011173480400_CIT0029","doi-asserted-by":"crossref","first-page":"581","DOI":"10.7326\/0003-4819-102-5-581","article-title":"Pericholangitis in chronic ulcerative colitis: primary sclerosing cholangitis of the small bile ducts?","volume":"102","author":"Wee","year":"1985","journal-title":"Ann Intern Med"},{"key":"2019121011173480400_CIT0030","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1053\/j.gastro.2008.01.042","article-title":"The natural history of small-duct primary sclerosing cholangitis","volume":"134","author":"Bj\u00f6rnsson","year":"2008","journal-title":"Gastroenterology"},{"key":"2019121011173480400_CIT0031","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/hep.23082","article-title":"High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis","volume":"50","author":"Lindor","year":"2009","journal-title":"Hepatology"},{"key":"2019121011173480400_CIT0032","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.cgh.2012.12.032","article-title":"Association between reduced levels of alkaline phosphatase and survival times of patients with primary sclerosing cholangitis","volume":"11","author":"Lindstr\u00f6m","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2019121011173480400_CIT0033","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.dld.2010.12.008","article-title":"Alkaline phosphatase normalization is associated with better prognosis in primary sclerosing cholangitis","volume":"43","author":"Stanich","year":"2011","journal-title":"Dig Liver Dis"},{"key":"2019121011173480400_CIT0034","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/lt.21679","article-title":"A re-evaluation of the risk factors for the recurrence of primary sclerosing cholangitis in liver allografts","volume":"15","author":"Alabraba","year":"2009","journal-title":"Liver Transpl"},{"key":"2019121011173480400_CIT0035","doi-asserted-by":"crossref","first-page":"e0193523","DOI":"10.1371\/journal.pone.0193523","article-title":"A novel learning algorithm to predict individual survival after liver transplantation for primary sclerosing cholangitis","volume":"13","author":"Andres","year":"2018","journal-title":"PLoS One"},{"key":"2019121011173480400_CIT0036","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/apt.12651","article-title":"Systematic review with meta-analysis: the declining risk of colorectal cancer in ulcerative colitis","volume":"39","author":"Casta\u00f1o-Milla","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"2019121011173480400_CIT0037","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cgh.2011.10.020","article-title":"Risk for colorectal neoplasia in patients with colonic Crohn\u2019s disease and concomitant primary sclerosing cholangitis","volume":"10","author":"Braden","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2019121011173480400_CIT0038","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/apt.13516","article-title":"Patients with large-duct primary sclerosing cholangitis and Crohn\u2019s disease have a better outcome than those with ulcerative colitis, or without IBD","volume":"43","author":"Fevery","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"2019121011173480400_CIT0039","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1478-3231.2011.02614.x","article-title":"Mortality and cancer risk related to primary sclerosing cholangitis in a Swedish population-based cohort","volume":"32","author":"de Valle","year":"2012","journal-title":"Liver Int"},{"key":"2019121011173480400_CIT0040","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/lt.22161","article-title":"Primary sclerosing cholangitis in genetically diverse populations listed for liver transplantation: unique clinical and human leukocyte antigen associations","volume":"16","author":"Bowlus","year":"2010","journal-title":"Liver Transpl"},{"key":"2019121011173480400_CIT0041","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.jhep.2017.07.022","article-title":"Primary sclerosing cholangitis - a comprehensive review","volume":"67","author":"Karlsen","year":"2017","journal-title":"J Hepatol"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ecco-jcc\/advance-article-pdf\/doi\/10.1093\/ecco-jcc\/jjz094\/28808973\/jjz094.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/13\/12\/1492\/31490633\/jjz094.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/13\/12\/1492\/31490633\/jjz094.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T16:59:00Z","timestamp":1721235540000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/13\/12\/1492\/5486538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,7]]},"references-count":41,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,5,7]]},"published-print":{"date-parts":[[2019,12,10]]}},"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjz094","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,12]]},"published":{"date-parts":[[2019,5,7]]}}}