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Previous research showed that both psychological disorders like post-traumatic stress disorder and metabolic diseases are more prevalent in the progeny of affected parents. This could suggest an epigenetic mode of transmission. Human studies give first insight into the scope of intergenerational influence of stressors but are limited in exploring the underlying mechanisms. Animal models have elucidated the mechanistic underpinnings of epigenetic transmission. In this review, we summarize progress on the mechanisms of paternal intergenerational transmission by means of sperm RNA in mouse models. We discuss relevant details for the modelling of RNA-mediated transmission, point towards currently unanswered questions and propose experimental considerations for tackling these questions.<\/jats:p>","DOI":"10.1093\/eep\/dvac011","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T04:21:49Z","timestamp":1650082909000},"source":"Crossref","is-referenced-by-count":17,"title":["Deciphering the RNA universe in sperm in its role as a vertical information carrier"],"prefix":"10.1093","volume":"8","author":[{"given":"Miriam","family":"Kretschmer","sequence":"first","affiliation":[{"name":"Department of Health Sciences and Technology, ETH Zurich, Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Winterthurerstrasse 190 , Zurich 8057, Switzerland"},{"name":"Neuroscience Centre Zurich, ETH Zurich and University of Zurich, Winterthurerstrasse 190 , Zurich 8057, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-1478","authenticated-orcid":false,"given":"Katharina","family":"Gapp","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Technology, ETH Zurich, Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Winterthurerstrasse 190 , Zurich 8057, Switzerland"},{"name":"Neuroscience Centre Zurich, ETH Zurich and University of Zurich, Winterthurerstrasse 190 , Zurich 8057, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,16]]},"reference":[{"key":"2022072711302898900_R1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0079-6123(07)67009-5","article-title":"Transgenerational transmission of cortisol and PTSD risk","volume":"167","author":"Yehuda","year":"2008","journal-title":"Prog Brain Res"},{"key":"2022072711302898900_R2","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1176\/appi.ajp.2014.13121571","article-title":"Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring","volume":"171","author":"Yehuda","year":"2014","journal-title":"Am J Psychiatry"},{"key":"2022072711302898900_R3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.earlhumdev.2006.07.001","article-title":"The Dutch famine and its long-term consequences for adult health","volume":"82","author":"Roseboom","year":"2006","journal-title":"Early Hum Dev"},{"key":"2022072711302898900_R4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.maturitas.2011.06.017","article-title":"Hungry in the womb: what are the consequences? 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