{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:05:35Z","timestamp":1787882735477,"version":"build-2784847793"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":334,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000073","name":"Autism Speaks","doi-asserted-by":"publisher","award":["7785"],"award-info":[{"award-number":["7785"]}],"id":[{"id":"10.13039\/100000073","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES016443 R01ES017646 R01ES023780 R01ES023780-04S01 R24ES030893"],"award-info":[{"award-number":["R01ES016443 R01ES017646 R01ES023780 R01ES023780-04S01 R24ES030893"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000073","name":"Autism Speaks","doi-asserted-by":"publisher","award":["7785"],"award-info":[{"award-number":["7785"]}],"id":[{"id":"10.13039\/100000073","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES016443 R01ES017646 R01ES023780 R01ES023780-04S01 R24ES030893"],"award-info":[{"award-number":["R01ES016443 R01ES017646 R01ES023780 R01ES023780-04S01 R24ES030893"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Exposure to air pollutants has been associated with adverse health outcomes in adults and children who were prenatally exposed. In addition to reducing exposure to air pollutants, it is important to identify their biologic targets in order to mitigate the health consequences of exposure. One molecular change associated with prenatal exposure to air pollutants is DNA methylation (DNAm), which has been associated with changes in placenta and cord blood tissues at birth. However, little is known about how air pollution exposure impacts the sperm epigenome, which could provide important insights into the mechanism of transmission to offspring. In the present study, we explored whether exposure to particulate matter less than 2.5 microns in diameter, particulate matter less than 10 microns in diameter, nitrogen dioxide (NO2), or ozone (O3) was associated with DNAm in sperm contributed by participants in the Early Autism Risk Longitudinal Investigation prospective pregnancy cohort. Air pollution exposure measurements were calculated as the average exposure for each pollutant measured within 4\u2009weeks prior to the date of sample collection. Using array-based genome-scale methylation analyses, we identified 80, 96, 35, and 67 differentially methylated regions (DMRs) significantly associated with particulate matter less than 2.5 microns in diameter, particulate matter less than 10 microns in diameter, NO2, and O3, respectively. While no DMRs were associated with exposure to all four pollutants, we found that genes overlapping exposure-related DMRs had a shared enrichment for gene ontology biological processes related to neurodevelopment. Together, these data provide compelling support for the hypothesis that paternal exposure to air pollution impacts DNAm in sperm, particularly in regions implicated in neurodevelopment.<\/jats:p>","DOI":"10.1093\/eep\/dvae003","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T15:49:43Z","timestamp":1707493783000},"source":"Crossref","is-referenced-by-count":22,"title":["Exposure to air pollution is associated with DNA methylation changes in sperm"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8224-9245","authenticated-orcid":false,"given":"Rose","family":"Schrott","sequence":"first","affiliation":[{"name":"Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205,","place":["USA"]},{"name":"Department of Mental Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 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University of California , Davis, CA 95616,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A","family":"Croen","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California , Oakland, CA 94612,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Daniele","family":"Fallin","sequence":"additional","affiliation":[{"name":"Rollins School of Public Health, Emory University , Atlanta, GA 30322,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather E","family":"Volk","sequence":"additional","affiliation":[{"name":"Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205,","place":["USA"]},{"name":"Department of Mental Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 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