{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:46:47Z","timestamp":1788292007453,"version":"build-2803163510"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":125,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000118","name":"Office of Behavioral and Social Sciences Research","doi-asserted-by":"publisher","award":["U24OD023319"],"award-info":[{"award-number":["U24OD023319"]}],"id":[{"id":"10.13039\/100000118","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["See details in the manuscript - long list"],"award-info":[{"award-number":["See details in the manuscript - long list"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000118","name":"Office of Behavioral and Social Sciences Research","doi-asserted-by":"publisher","award":["U24OD023319"],"award-info":[{"award-number":["U24OD023319"]}],"id":[{"id":"10.13039\/100000118","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["See details in the manuscript - long list"],"award-info":[{"award-number":["See details in the manuscript - long list"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prenatal exposure to air pollution is an important risk factor for child health outcomes, including asthma. Identification of DNA methylation changes associated with air pollutant exposure can provide new intervention targets to improve children\u2019s health. The aim of this study is to test the association between prenatal air pollutant exposure and DNA methylation in developmental and asthma-\/allergy-relevant biospecimens (placenta, buccal, cord blood, nasal mucosa, and lavage). A subset of 2294 biospecimens collected from 1906 child participants enrolled in the Environmental Influences on Child Health Outcomes program with prenatal air pollutant and high-quality Illumina Asthma&amp;Allergy DNA methylation array measures (n\u2009=\u200937\u2009197 probes) were included. Prenatal ozone, nitrogen dioxide, and fine particulate matter were derived using residential history during pregnancy and spatiotemporal models. For each pollutant, biospecimen type, and prenatal exposure window, we estimated the effects of air pollution on gene DNA methylation levels. We compared results across pollutants, biospecimen types, and trimesters and tested for critical months of exposure using distributed lag models. DNA methylation levels at 154 out of 4746 tested genes were associated with air pollution; over 95% were exposure window, pollutant, and biospecimen-type specific. The fewest gene associations were detected in trimester 2, relative to other exposure windows. A variety of trends in methylation patterns were observed in response to lagged monthly pollution levels. Child DNA methylation changes at specific respiratory- and immune-relevant genes are associated with prenatal air pollutant exposures. Future studies should examine the relationship between these pollution-sensitive genes and child health.<\/jats:p>","DOI":"10.1093\/eep\/dvaf013","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T09:30:05Z","timestamp":1746178205000},"source":"Crossref","is-referenced-by-count":10,"title":["Prenatal ambient air pollution associations with DNA methylation in asthma- and allergy-relevant genes: findings from ECHO"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4801-8122","authenticated-orcid":false,"given":"Meredith","family":"Palmore","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma E","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Chicago , Chicago, IL 60637,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"Genomics and Translational Research Center, RTI International, Research Triangle Park , NC 27709,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa M","family":"Bastain","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, University of Southern California , Los Angeles, CA 90032,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6082-4066","authenticated-orcid":false,"given":"Carrie","family":"Breton","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, University of Southern California , Los Angeles, CA 90032,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Collingwood","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Utah , Salt Lake City, UT 84108,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank D","family":"Gilliland","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, University of Southern California , Los Angeles, CA 90032,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane R","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T. Chan School of Public Health , Boston, MA 02115,","place":["United States"]},{"name":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Habre","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Spatial Sciences, University of Southern California , Los Angeles, CA 90032,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7470-1166","authenticated-orcid":false,"given":"Tina","family":"Hartert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurjit K","family":"Khurana Hershey","sequence":"additional","affiliation":[{"name":"Division of 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