{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:43:38Z","timestamp":1778942618491,"version":"3.51.4"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"DOI":"10.1093\/eep\/dvx014","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T17:58:57Z","timestamp":1509731937000},"source":"Crossref","is-referenced-by-count":11,"title":["Multigenerational analysis of sex-specific phenotypic differences at midgestation caused by abnormal folate metabolism"],"prefix":"10.1093","volume":"3","author":[{"given":"Nisha","family":"Padmanabhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Rakoczy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Kondratowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Menelaou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina E T","family":"Blake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4496-2271","authenticated-orcid":false,"given":"Erica D","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"key":"key\n\t\t\t\t20180125123245_dvx014-B1","first-page":"50","article-title":"Placental contribution to nutritional programming of health and diseases: epigenetics and sexual dimorphism","volume":"218(Pt 1)","year":"2015","journal-title":"J Exp Biol"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B2","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/REP-11-0489","article-title":"Sex differences in developmental programming models","volume":"145","year":"2013","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1126\/science.aad7977","article-title":"Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder","volume":"351","year":"2016","journal-title":"Science"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/ng.3527","article-title":"Epigenetic germline inheritance of diet-induced obesity and insulin resistance","volume":"48","year":"2016","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1126\/science.aad6780","article-title":"Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals","volume":"351","year":"2016","journal-title":"Science"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B6","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1108190","article-title":"Epigenetic transgenerational actions of endocrine disruptors and male fertility","volume":"308","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B7","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nn.3695","article-title":"Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice","volume":"17","year":"2014","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cell.2013.09.002","article-title":"Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development","volume":"155","year":"2013","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B9","doi-asserted-by":"crossref","first-page":"1255903","DOI":"10.1126\/science.1255903","article-title":"In utero effects. In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism","volume":"345","year":"2014","journal-title":"Science"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cbpa.2016.06.008","article-title":"Unravelling the complex mechanisms of transgenerational epigenetic inheritance","volume":"33","year":"2016","journal-title":"Curr Opin Chem Biol"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B11","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/ajhb.22594","article-title":"The anthropometry of children and adolescents may be influenced by the prenatal smoking habits of their grandmothers: a longitudinal cohort study","volume":"26","year":"2014","journal-title":"Am J Hum Biol"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s12864-015-1506-4","article-title":"Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development","volume":"16","year":"2015","journal-title":"BMC Genomics"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B13","first-page":"S33","article-title":"Review: Sex and the human placenta: mediating differential strategies of fetal growth and survival","volume":"31(Suppl.)","year":"2010","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B14","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1093\/jn\/134.11.2975","article-title":"Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates","volume":"134","year":"2004","journal-title":"J Nutr"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B15","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/jn\/128.7.1204","article-title":"Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women","volume":"128","year":"1998","journal-title":"J Nutr"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B16","first-page":"2830","article-title":"Ethionine-induced changes in rat liver transfer RNA methylation","volume":"35","year":"1975","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B17","doi-asserted-by":"crossref","first-page":"9476","DOI":"10.1073\/pnas.0603694103","article-title":"Human methionine synthase reductase is a molecular chaperone for human methionine synthase","volume":"103","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ymgme.2007.02.001","article-title":"Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase","volume":"91","year":"2007","journal-title":"Mol Genet Metab"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B19","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.3390\/nu5114760","article-title":"Folate deficiency and folic acid supplementation: the prevention of neural-tube defects and congenital heart defects","volume":"5","year":"2013","journal-title":"Nutrients"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B20","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/bdra.20575","article-title":"Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice","volume":"85","year":"2009","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B21","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1159\/000329935","article-title":"Urinary tract anomalies associated with MTHFR gene polymorphism C677T in girls","volume":"34","year":"2011","journal-title":"Kidney Blood Press Res"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B22","doi-asserted-by":"crossref","first-page":"46959","DOI":"10.18632\/oncotarget.10506","article-title":"Sex-specific metabolic interactions between liver and adipose tissue in MCD diet-induced non-alcoholic fatty liver disease","volume":"7","year":"2016","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3945\/jn.109.119453","article-title":"A methyl-deficient diet fed to rat dams during the peri-conception period programs glucose homeostasis in adult male but not female offspring","volume":"141","year":"2011","journal-title":"J Nutr"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B24","doi-asserted-by":"crossref","first-page":"710","DOI":"10.4161\/epi.24948","article-title":"High folate gestational and post-weaning diets alter hypothalamic feeding pathways by DNA methylation in Wistar rat offspring","volume":"8","year":"2013","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B25","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1158\/1055-9965.EPI-04-0905","article-title":"Sex differences in risk of lung cancer associated with methylene-tetrahydrofolate reductase polymorphisms. Cancer","volume":"14","year":"2005","journal-title":"Epidemiol Biomarkers Prev"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1001\/jama.2016.19438","article-title":"Folic acid supplementation for the prevention of neural tube defects: US preventive services task force recommendation statement","volume":"317","author":"U.S. Preventative Services Task Force","year":"2017","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B27","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/hmg\/dds494","article-title":"Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development","volume":"22","year":"2013","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/mrd.1081","article-title":"Rapid DNA extraction and PCR-sexing of mouse embryos","volume":"60","year":"2001","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000348677","article-title":"Novel PCR assay for determining the genetic sex of mice","volume":"7","year":"2013","journal-title":"Sex Dev"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B30","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/bdra.10129","article-title":"Differential risks to males and females for congenital malformations among 2.5 million California births, 1989-1997","volume":"67","year":"2003","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B31","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/bdra.22846","article-title":"Sex differences in the prevalence of congenital anomalies: a population-based study","volume":"91","year":"2011","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B32","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.rbmo.2013.09.008","article-title":"Lessons from the one-carbon metabolism: passing it along to the next generation","volume":"27","year":"2013","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0140-6736(91)90133-A","article-title":"Prevention of neural tube defects: results of the Medical Research Council Vitamin Study","volume":"338","author":"MRC Vitamin Study Research Group","year":"1991","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B34","first-page":"133","volume-title":"Folate in Health and Disease","year":"2010"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B35","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1056\/NEJMoa067103","article-title":"Reduction in neural-tube defects after folic acid fortification in Canada","volume":"357","year":"2007","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B36","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1101\/gad.234294.113","article-title":"DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos","volume":"28","year":"2014","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B37","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1111\/j.1742-4658.2011.08029.x","article-title":"Sex determination and the control of Sox9 expression in mammals","volume":"278","year":"2011","journal-title":"FEBS J"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B38","first-page":"180","article-title":"Development of structures and transport functions in the mouse placenta","volume":"20","year":"2005","journal-title":"Physiology (Bethesda)"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B39","doi-asserted-by":"crossref","first-page":"19219","DOI":"10.1073\/pnas.0504468103","article-title":"Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B40","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1073\/pnas.1000440107","article-title":"Contrasting effects of different maternal diets on sexually dimorphic gene expression in the murine placenta","volume":"107","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B41","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1210\/en.2015-1227","article-title":"Sex-specific placental responses in fetal development","volume":"156","year":"2015","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B42","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.placenta.2012.11.009","article-title":"Sexually dimorphic placental development throughout gestation in the spiny mouse (Acomys cahirinus)","volume":"34","year":"2013","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B43","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/ajhb.20995","article-title":"Boys live dangerously in the womb","volume":"22","year":"2010","journal-title":"Am J Hum Biol"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B44","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/ng.3554","article-title":"Fat eggs shape offspring health","volume":"48","year":"2016","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B45","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.placenta.2012.02.005","article-title":"Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development","volume":"33","year":"2012","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20180125123245_dvx014-B46","first-page":"40","article-title":"Placental nutrient transport and intrauterine growth restriction","volume":"7","year":"2016","journal-title":"Front Physiol"}],"container-title":["Environmental Epigenetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/eep\/article-pdf\/3\/4\/dvx014\/23652385\/dvx014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T02:37:37Z","timestamp":1603247857000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/eep\/article\/doi\/10.1093\/eep\/dvx014\/4590249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,1]]},"references-count":46,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,11,3]]},"published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/eep\/dvx014","relation":{},"ISSN":["2058-5888"],"issn-type":[{"value":"2058-5888","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,10]]},"published":{"date-parts":[[2017,10,1]]}}}