{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:33:03Z","timestamp":1790429583470,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"RHU MARVELOUS","award":["ANR-16-RHUS-0009"],"award-info":[{"award-number":["ANR-16-RHUS-0009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Important controversies remain concerning the determinants of life-threatening arrhythmias during ST-segment elevation myocardial infarction (STEMI) and their impact on late adverse events. This study sought to investigate which factors might facilitate ventricular tachycardia (VT) and ventricular fibrillation (VF), in a homogeneous population of anterior STEMI patients defined by abrupt left anterior descending coronary artery (LAD) occlusion and no collateral flow.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The 967 patients, who entered into the CIRCUS (Does Cyclosporine ImpRove Clinical oUtcome in ST elevation myocardial infarction patients) study, were assessed for further analysis. Acute VT\/VF was defined as VT (run of tachycardia &amp;gt;30 s either self-terminated or requiring electrical\/pharmacological cardioversion) or VF documented by electrocardiogram or cardiac monitoring, during transportation to the cathlab or initial hospitalization. VT\/VF was documented in 136 patients (14.1%). Patients with VT\/VF were younger and had shorter time from symptom onset to hospital arrival. Site of LAD occlusion, thrombus burden, area at risk, pre-percutaneous coronary intervention Thrombolysis in Myocardial Infarction flow, and ST-segment resolution were similar to that of patients without VT\/VF. There was no impact of VT\/VF on left ventricular remodelling or clinical outcomes. By multivariate analysis, the use of morphine (odds ratio 1.71; 95% confidence interval (1.13\u20132.60); P\u2009=\u20090.012) was the sole independent predictor of VT\/VF occurrence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In STEMI patients with LAD occlusion, our findings support the view that morphine could favour severe ventricular arrhythmias.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuaa005","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T04:14:14Z","timestamp":1609474454000},"page":"427-436","source":"Crossref","is-referenced-by-count":4,"title":["Life-threatening arrhythmias in anterior ST-segment elevation myocardial infarction patients treated by percutaneous coronary intervention: adverse impact of morphine"],"prefix":"10.1093","volume":"10","author":[{"given":"Fran\u00e7ois","family":"Sauer","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d\u2019Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, BP 426, 67091 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Jesel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d\u2019Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, BP 426, 67091 Strasbourg, France"},{"name":"UMR 1260 INSERM Nanom\u00e9decine R\u00e9g\u00e9n\u00e9rative Universit\u00e9 de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Marchandot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d\u2019Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, BP 426, 67091 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Derimay","sequence":"additional","affiliation":[{"name":"Hopital Cardiovasculaire Louis Pradel, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bochaton","sequence":"additional","affiliation":[{"name":"Hopital Cardiovasculaire Louis Pradel, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Amaz","sequence":"additional","affiliation":[{"name":"Centre d\u2019Investigation Clinique de Lyon, CIC 1407, H\u00f4pital Louis Pradel, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Roubille","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Universitaires de Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Cayla","sequence":"additional","affiliation":[{"name":"H\u00f4pital de N\u00eemes, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Rioufol","sequence":"additional","affiliation":[{"name":"Hopital Cardiovasculaire Louis Pradel, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Garcia-Dorado","sequence":"additional","affiliation":[{"name":"Hospital Universitaire Vall d\u2019Hebron, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Claeys","sequence":"additional","affiliation":[{"name":"University Hospital Antwerp, Edegem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Angoulvant","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Regional Universitaire de Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bonnefoy-Cudraz","sequence":"additional","affiliation":[{"name":"Hopital Cardiovasculaire Louis Pradel, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Gu\u00e9rin","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Universitaires de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Trinh","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d\u2019Activit\u00e9 M\u00e9dico-Chirurgicale Cardio-Vasculaire, Nouvel H\u00f4pital Civil, Centre Hospitalier Universitaire, BP 426, 67091 Strasbourg, 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