{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:27:08Z","timestamp":1789547228162,"version":"build-2803163510"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007405","name":"Danish Heart Foundation","doi-asserted-by":"publisher","award":["18-R125-A8472-22085"],"award-info":[{"award-number":["18-R125-A8472-22085"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"name":"J\u00f8rgen M\u00f8ller foundation"},{"name":"Abiomed"},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R186-2015-2132"],"award-info":[{"award-number":["R186-2015-2132"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The objective was to describe patient characteristics, interventions, and outcome in acute myocardial infarction complicated by cardiogenic shock (AMICS), due to predominantly right ventricular (RV) failure after revascularization, in comparison with patients suffering from left ventricular (LV) failure as these patients remain sparsely characterized.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>From 2010 to 2017, consecutive AMICS patients admitted to either of two tertiary heart centres, covering 3.9 million citizens, corresponding to two-thirds of the Danish population, were identified and individually reviewed through patient records. A total of 1716 AMICS patients were identified, of which 1482 underwent acute revascularization and included for analysis. Hereof, 101 (7%) patients developed cardiogenic shock due to predominantly RV failure, while 1381 (93%) had significant LV involvement. Female sex was the only demographic factor associated with RV failure (35% vs. 25%, P\u2009=\u20090.01). Despite having a preserved LV ejection fraction, patients with predominantly RV failure were comparable to patients with LV involvement, in terms of haemodynamic and metabolic profile, here among variables commonly used in the cardiogenic shock definition including blood pressure (82 mmHg vs. 83 mmHg, P\u2009=\u20090.90) and lactate level (5.7 mmol\/L vs. 5.4 mmol\/L, P\u2009=\u20090.70). Patients with RV AMICS had significantly lower 30-day mortality than LV AMICS, and this result persisted after multivariable adjustment (RV vs. LV; hazard ratio 0.61, 95% confidence interval 0.41\u20130.92, P\u2009=\u20090.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In contemporary AMICS patients undergoing revascularization, patients with predominantly RV failure had comparable haemodynamics and metabolic derangement on admission compared to patients with LV failure but was associated with female sex and a significantly lower 30-day mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuaa010","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T04:14:14Z","timestamp":1609474454000},"page":"33-39","source":"Crossref","is-referenced-by-count":14,"title":["Cardiogenic shock due to predominantly right ventricular failure complicating acute myocardial infarction"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3984-7781","authenticated-orcid":false,"given":"Jakob","family":"Josiassen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Kristian L","family":"Helgestad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, J. B. Winsl\u00f8ws Vej 4, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"},{"name":"Department of Cardiology, Odense University Hospital, J. B. Winsl\u00f8ws Vej 4, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia, Odense University Hospital, Odense, J. B. Winsl\u00f8ws Vej 4, 5000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette O","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, J. B. Winsl\u00f8ws Vej 4, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Holmvang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4702-5195","authenticated-orcid":false,"given":"Hanne B","family":"Ravn","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2100 Copenhagen, Denmark"},{"name":"Department of Cardiothoracic Anaesthesia, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"2021072111395327400_zuaa010-B1","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/ejhf.1566","article-title":"Temporal trends in incidence and patient characteristics in cardiogenic shock following acute myocardial infarction from 2010 to 2017: a Danish cohort study","volume":"21","author":"Helgestad","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2021072111395327400_zuaa010-B2","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1161\/CIRCULATIONAHA.108.814947","article-title":"Thirty-year trends (1975 to 2005) in the magnitude of, management of, and hospital death rates associated with cardiogenic shock in patients with acute myocardial infarction: a population-based perspective","volume":"119","author":"Goldberg","year":"2009","journal-title":"Circulation"},{"key":"2021072111395327400_zuaa010-B3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/CIRCOUTCOMES.115.002359","article-title":"Decade-long trends (2001-2011) in the incidence and hospital death rates associated with the in-hospital development of cardiogenic shock after acute myocardial infarction","volume":"9","author":"Goldberg","year":"2016","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2021072111395327400_zuaa010-B4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/eurjhf\/hfp204","article-title":"Right ventricular dysfunction is an independent predictor for mortality in ST-elevation myocardial infarction patients presenting with cardiogenic shock on admission","volume":"12","author":"Engstrom","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"2021072111395327400_zuaa010-B5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/2048872619894254","article-title":"Acute Cardiovascular Care Association position statement for the diagnosis and treatment of patients with acute myocardial infarction complicated by cardiogenic shock: a document of the Acute Cardiovascular Care Association of the European Society of Cardiology","volume":"9","author":"Zeymer","year":"2020","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"2021072111395327400_zuaa010-B6","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1001\/jama.297.15.joc70035","article-title":"Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial","volume":"297","author":"Alexander","year":"2007","journal-title":"JAMA"},{"key":"2021072111395327400_zuaa010-B7","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.jacc.2008.05.065","article-title":"A randomized clinical trial to evaluate the safety and efficacy of a percutaneous left ventricular assist device versus intra-aortic balloon pumping for treatment of cardiogenic shock caused by myocardial infarction","volume":"52","author":"Seyfarth","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2021072111395327400_zuaa010-B8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ahj.2019.04.019","article-title":"Rationale and design of DanGer shock: Danish-German cardiogenic shock trial","volume":"214","author":"Udesen","year":"2019","journal-title":"Am Heart J"},{"key":"2021072111395327400_zuaa010-B9","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1056\/NEJM199908263410901","article-title":"Early revascularization in acute myocardial infarction complicated by cardiogenic shock. 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