{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T13:03:42Z","timestamp":1773061422583,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"CIBER CV","award":["16\/11\/00420"],"award-info":[{"award-number":["16\/11\/00420"]}]},{"name":"CIBER CV","award":["16\/11\/00403"],"award-info":[{"award-number":["16\/11\/00403"]}]},{"name":"Instituto de Salud Carlos III-FEDER","award":["PIE15\/00013"],"award-info":[{"award-number":["PIE15\/00013"]}]},{"name":"Instituto de Salud Carlos III-FEDER","award":["PI17\/01836"],"award-info":[{"award-number":["PI17\/01836"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Iron deficiency (ID) is a frequent finding in patients with chronic and acute heart failure (AHF) along the full spectrum of left ventricular ejection fraction (LVEF). Iron deficiency has been related to ventricular systolic dysfunction, but its role in right ventricular function has not been evaluated. We sought to evaluate whether ID identifies patients with greater right ventricular dysfunction in the setting of AHF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We prospectively included 903 patients admitted with AHF. Right systolic function was evaluated by tricuspid annular plane systolic excursion (TAPSE) and the ratio TAPSE\/pulmonary artery systolic pressure (TAPSE\/PASP). Iron deficiency was defined, according to European Society of Cardiology criteria, as serum ferritin &amp;lt;100\u2009mg\/dL (absolute ID) or ferritin 100\u2013299\u2009mg\/dL and transferrin saturation (TSAT) &amp;lt;20% (functional ID). The relationships among the exposures with right ventricular systolic function were evaluated by multivariate linear regression analyses. The mean age of the sample was 74.3\u2009\u00b1\u200910.6\u2009years, 441 (48.8%) were female, 471 (52.2%) exhibited heart failure with preserved ejection fraction, and 677 (75.0%) showed ID. The mean LVEF, TAPSE, and TAPSE\/PASP were 49\u2009\u00b1\u200915%, 18.6\u2009\u00b1\u20093.9\u2009mm, and 0.45\u2009\u00b1\u20090.18, respectively. The median (interquartile range) amino-terminal pro-brain natriuretic peptide was 4015 (1807\u20138775) pg\/mL. In a multivariable setting, lower TSAT and ferritin were independently associated with lower TAPSE (P\u2009&amp;lt;\u20090.05 for both comparisons). Transferrin saturation (P\u2009=\u20090.017), and not ferritin (P\u2009=\u20090.633), was independently associated with TAPSE\/PASP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In AHF, proxies of ID were associated with right ventricular dysfunction. Further studies should confirm these findings and evaluate the pathophysiological facts behind this association.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuaa028","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T04:14:14Z","timestamp":1609474454000},"page":"406-414","source":"Crossref","is-referenced-by-count":15,"title":["Right ventricular function and iron deficiency in acute heart failure"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8777-2588","authenticated-orcid":false,"given":"Gema","family":"Mi\u00f1ana","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, Universitat de Valencia, INCLIVA, Avda. Blasco Ib\u00e1\u00f1ez 17, 46010 Valencia, Spain"},{"name":"CIBER Cardiovascular, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Santas","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, Universitat de Valencia, INCLIVA, Avda. Blasco Ib\u00e1\u00f1ez 17, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"de la Espriella","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, Universitat de Valencia, INCLIVA, Avda. Blasco Ib\u00e1\u00f1ez 17, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, Universitat de Valencia, INCLIVA, Avda. Blasco Ib\u00e1\u00f1ez 17, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, Universitat de Valencia, INCLIVA, Avda. Blasco Ib\u00e1\u00f1ez 17, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, Universitat de Valencia, INCLIVA, Avda. Blasco Ib\u00e1\u00f1ez 17, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Valero","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, Universitat de Valencia, INCLIVA, Avda. Blasco Ib\u00e1\u00f1ez 17, 46010 Valencia, Spain"},{"name":"CIBER Cardiovascular, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicent","family":"Bod\u00ed","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, Universitat de Valencia, INCLIVA, Avda. Blasco Ib\u00e1\u00f1ez 17, 46010 Valencia, Spain"},{"name":"CIBER Cardiovascular, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J","family":"Chorro","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, Universitat de Valencia, INCLIVA, Avda. Blasco Ib\u00e1\u00f1ez 17, 46010 Valencia, Spain"},{"name":"CIBER Cardiovascular, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Sanchis","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, Universitat de Valencia, INCLIVA, Avda. Blasco Ib\u00e1\u00f1ez 17, 46010 Valencia, Spain"},{"name":"CIBER Cardiovascular, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Cohen-Solal","sequence":"additional","affiliation":[{"name":"Cardiology Department, UMR-S942, University of Paris, Lariboisiere Hospital, AP-HP, 2 rue ambroise pare, Paris 75010, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Bay\u00e9s-Gen\u00eds","sequence":"additional","affiliation":[{"name":"CIBER Cardiovascular, Madrid, Spain"},{"name":"Cardiology Department and Heart Failure Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain"},{"name":"Autonomous University of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-7119","authenticated-orcid":false,"given":"Julio","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, Universitat de Valencia, INCLIVA, Avda. 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