{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T13:40:37Z","timestamp":1768916437851,"version":"3.49.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary percutaneous coronary intervention (PPCI) has dramatically changed the outcome of patients with ST-elevation myocardial infarction (STEMI). However, despite improvements in interventional technology, registry data show little recent change in the prognosis of patients who survive STEMI, with a significant incidence of cardiogenic shock, heart failure, and cardiac death. Despite a technically successful PPCI procedure, a variable proportion of patients experience suboptimal myocardial reperfusion. Large infarct size and coronary microvascular injury, as the consequence of ischaemia\u2013reperfusion injury and distal embolization of atherothrombotic debris, account for suboptimal long-term prognosis of STEMI patients. In order to address this unmet therapeutic need, a broad-range of device-based treatments has been developed. These device-based therapies can be categorized according to the pathophysiological pathways they target: (i) techniques to prevent distal atherothrombotic embolization, (ii) techniques to prevent or mitigate ischaemia\/reperfusion injury, and (iii) techniques to enhance coronary microvascular function\/integrity. This review is an overview of these novel technologies with a focus on their pathophysiological background, procedural details, available evidence, and with a critical perspective about their potential future implementation in the clinical care of STEMI patients.<\/jats:p>","DOI":"10.1093\/ehjacc\/zuab012","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T20:30:46Z","timestamp":1614803446000},"page":"687-697","source":"Crossref","is-referenced-by-count":13,"title":["Novel device-based therapies to improve outcome in ST-segment elevation myocardial infarction"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3572-1855","authenticated-orcid":false,"given":"Giovanni Luigi","family":"De Maria","sequence":"first","affiliation":[{"name":"Oxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector M","family":"Garcia-Garcia","sequence":"additional","affiliation":[{"name":"MedStar Washington Hospital Centre\u2014Interventional Cardiology Department, 110 Irving St NW, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Scarsini","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of Verona, Piazzale Aristide Stefani 1, 37126, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aloke","family":"Finn","sequence":"additional","affiliation":[{"name":"CVPath Institute, Gaithersburg, 19 Firstfield Rd, Gaithersburg, MD 20878, USA"},{"name":"School of Medicine, University of Maryland, Baltimore, 655 W Baltimore St, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6878-1243","authenticated-orcid":false,"given":"Yu","family":"Sato","sequence":"additional","affiliation":[{"name":"CVPath Institute, Gaithersburg, 19 Firstfield Rd, Gaithersburg, MD 20878, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renu","family":"Virmani","sequence":"additional","affiliation":[{"name":"CVPath Institute, Gaithersburg, 19 Firstfield Rd, Gaithersburg, MD 20878, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravinay","family":"Bhindi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal North Shore Hospital, Reserve Road, ST. Leonard 2065, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan L","family":"Ciofani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal North Shore Hospital, Reserve Road, ST. Leonard 2065, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Nuche","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle Melchor Fern\u00e1ndez Almagro 3, 28029, Madrid, Spain"},{"name":"Servicio de Cardiolog\u00eda, Hospital Universitario 12 de Octubre, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), Cordoba avenue, 28041, Madrid, Spain"},{"name":"CIBERCV, Av. Monforte de Lemos, 3-5. Pabell\u00f3n, 11. 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Planta 0 28029, Madrid, Spain"},{"name":"IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Calle Isaac Peral, 28015 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico H J","family":"Pijls","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital, Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute, 920 E 28th St Ste 100, Minneapolis, MN 55407, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navin K","family":"Kapur","sequence":"additional","affiliation":[{"name":"The Cardiovascular Centre, Tufts Medical Centre, 800 Washington St, Boston, MA 02111, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-8210","authenticated-orcid":false,"given":"Gregg W","family":"Stone","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. 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