{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:59:40Z","timestamp":1778633980233,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Prognosis models based on stepwise regression methods show modest performance in patients with cardiogenic shock (CS). Automated variable selection allows data-driven risk evaluation by recognizing distinct patterns in data. We sought to evaluate an automated variable selection method (least absolute shrinkage and selection operator, LASSO) for predicting 30-day mortality in patients with acute myocardial infarction and CS (AMICS) receiving acute percutaneous coronary intervention (PCI) compared to two established scores.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Consecutive patients with AMICS receiving acute PCI at one of two tertiary heart centres in Denmark 2010\u20132017. Patients were divided according to treatment with mechanical circulatory support (MCS); PCI\u2013MCS cohort (n\u2009=\u2009220) versus PCI cohort (n\u2009=\u20091180). The latter was divided into a development (2010\u20132014) and a temporal validation cohort (2015\u20132017). Cohort-specific LASSO models were based on data obtained before PCI. LASSO models outperformed IABP-SHOCK II and CardShock risk scores in discriminative ability for 30-day mortality in the PCI validation [receiver operating characteristics area under the curve (ROC AUC) 0.80 (95% CI 0.76\u20130.84) vs 0.73 (95% CI 0.69\u20130.77) and 0.70 (95% CI 0.65\u20130.75), respectively, P\u2009&amp;lt;\u20090.01 for both] and PCI\u2013MCS development cohort [ROC AUC 0.77 (95% CI 0.70\u20130.83) vs 0.64 (95% CI 0.57\u20130.71) and 0.64 (95% CI 0.57\u20130.71), respectively, P\u2009&amp;lt;\u20090.01 for both]. Variable influence differed depending on MCS, with age being the most influential factor in the LASSO\u2013PCI model, whereas haematocrit and estimated glomerular filtration rate were the highest-ranking factors in the LASSO\u2013PCI\u2013MCS model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Data-driven prognosis models outperformed established risk scores in patients with AMICS receiving acute PCI and exhibited good discriminative abilities. Observations indicate a potential use of machinelearning to facilitate individualized patient care and targeted interventions in the future.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuab045","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T12:44:43Z","timestamp":1622724283000},"page":"668-675","source":"Crossref","is-referenced-by-count":6,"title":["Data-driven point-of-care risk model in patients with acute myocardial infarction and cardiogenic shock"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-8758","authenticated-orcid":false,"given":"Ole K L","family":"Helgestad","sequence":"first","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29, Entrance 20, 4th floor, 5000 Odense, Denmark"},{"name":"OPEN\u2014Open Patient data Explorative Network, Odense University Hospital, J.B. Winsl\u00f8ws Vej 9 A, 4th floor, 5000 Odense C, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Clinical Pharmacology, Aarhus University Hospital, Victor Albeck bygningen, Vennelyst Boulevard 4, 8000 AArhus C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6044-8841","authenticated-orcid":false,"given":"Amalie L","family":"Povlsen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, staircase 3, 5th floor, 2100 Copenhagen East, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3984-7781","authenticated-orcid":false,"given":"Jakob","family":"Josiassen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Inge Lehmanns Vej 7, staircase 2, 15th floor, 2100 Copenhagen East, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f6ren","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"OPEN\u2014Open Patient data Explorative Network, Odense University Hospital, J.B. Winsl\u00f8ws Vej 9 A, 4th floor, 5000 Odense C, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1199-0981","authenticated-orcid":false,"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Inge Lehmanns Vej 7, staircase 2, 15th floor, 2100 Copenhagen East, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-2429","authenticated-orcid":false,"given":"Lisette O","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29, Entrance 20, 4th floor, 5000 Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0941-378X","authenticated-orcid":false,"given":"Lene","family":"Holmvang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Inge Lehmanns Vej 7, staircase 2, 15th floor, 2100 Copenhagen East, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia, Odense University Hospital, .B. Winsl\u00f8wsvej 4, 5000 Odense C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-5845","authenticated-orcid":false,"given":"Jacob E","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Inge Lehmanns Vej 7, staircase 2, 15th floor, 2100 Copenhagen East, Denmark"},{"name":"University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4702-5195","authenticated-orcid":false,"given":"Hanne B","family":"Ravn","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, staircase 3, 5th floor, 2100 Copenhagen East, Denmark"},{"name":"Department of Cardiothoracic Anaesthesia, Odense University Hospital, .B. 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