{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:59:41Z","timestamp":1792144781692,"version":"4.4.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T00:00:00Z","timestamp":1628899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To report the incidence, the predictors and clinical impact of device-related complications (DRCs) in the IMP-IT (IMPella Mechanical Circulatory Support Device in Italy) registry. Impella is percutaneous left ventricular assist devices, which provides mechanical circulatory support both in cardiogenic shock (CS) and high-risk percutaneous coronary intervention (HR-PCI). The IMP-IT registry is a multicentre registry evaluating the trends in use and clinical outcomes of Impella in Italy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A total of 406 patients have been included in this registry: 56.4% in the setting of CS, while 43.6% patients in the setting of HR-PCI. DRCs were defined as a composite endpoint of access-site bleeding, limb ischaemia, vascular complication requiring treatment, haemolysis, aortic injury, and left ventricular perforation. DRC incidence in the overall population was 25.6%, with significantly higher rate in the CS (37.1%) than in the HR-PCI (10.7%) group. The most frequent complication was haemolysis (11.8%), which occurred almost exclusively in CS population. Access-site bleeding was observed in 9.6% of the overall population, with no significant difference between the two groups. Limb ischaemia was observed in 8.3% of the overall population, with significantly higher rate in the CS group. CS and right ventricular dysfunction appear as the strongest independent predictors of DRC. One-year mortality in patients with DRC appears higher than in patients with no DRC. However, DRC was not confirmed as an independent predictor of 1-year mortality at multivariate analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In the IMP-IT registry, the rate of DRC was 25.6%, with CS being the strongest independent predictor. DRC was not found as an independent predictor of 1-year mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuab051","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T03:15:52Z","timestamp":1624504552000},"page":"999-1006","source":"Crossref","is-referenced-by-count":26,"title":["Device-related complications after Impella mechanical circulatory support implantation: an IMP-IT observational multicentre registry substudy"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7944-9756","authenticated-orcid":false,"given":"Marco B","family":"Ancona","sequence":"first","affiliation":[{"name":"Interventional Cardiology Unit, IRCCS San Raffaele Scientific Institute, 60, Via Olgettina, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-9459","authenticated-orcid":false,"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, IRCCS San Raffaele Scientific Institute, 60, Via Olgettina, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Masiero","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Via Giustiniani 2 - 35128, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-9401","authenticated-orcid":false,"given":"Francesco","family":"Burzotta","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Largo Gemelli, 1 - 00168, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2105-8186","authenticated-orcid":false,"given":"Carlo","family":"Briguori","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Mediterranea Cardiocentro, Via Orazio 2 - 80121, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pagnesi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60 - 20132, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Pazzanese","sequence":"additional","affiliation":[{"name":"Department of Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60 - 20132, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9777-013X","authenticated-orcid":false,"given":"Carlo","family":"Trani","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Largo Gemelli, 1 - 00168, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Piva","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Ospedali Riuniti di Ancona, via Conca 71, 60126 - Ancona, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"De Marco","sequence":"additional","affiliation":[{"name":"Department of Clinical and Interventional Cardiology, IRCCS Policlinico San Donato, Piazza Edmondo Malan 2 - 20097 - San Donato Milanese, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Di Biasi","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Ospedale Luigi Sacco, via G.B.Grassi 74 - 20157, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pagnotta","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Humanitas Research Hospital, Via Alessandro Manzoni, 56 - 20089, Rozzano (MI), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavino","family":"Casu","sequence":"additional","affiliation":[{"name":"Clinical cardiology and Interventional cardiology Unit, Azienda Ospedaliera Universitaria Sassari, Via E. 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