{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:12:49Z","timestamp":1792653169853,"version":"4.5.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To assess differences in long-term outcome and functional status of patients with cardiogenic shock (CS) treated by percutaneous mechanical circulatory support (pMCS) and intra-aortic balloon pump (IABP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Long-term follow-up of the multicentre, randomized IMPRESS in Severe Shock trial (NTR3450) was performed 5-year after initial randomization. Between 2012 and 2015, a total of 48 patients with severe CS from acute myocardial infarction (AMI) with ST-segment elevation undergoing immediate revascularization were randomized to pMCS by Impella CP (n\u2009=\u200924) or IABP (n\u2009=\u200924). For the 5-year assessment, all-cause mortality, functional status, and occurrence of major adverse cardiac and cerebrovascular event (MACCE) were assessed. MACCE consisted of death, myocardial re-infarction, repeat percutaneous coronary intervention, coronary artery bypass grafting, and stroke. Five-year mortality was 50% (n\u2009=\u200912\/24) in pMCS patients and 63% (n\u2009=\u200915\/24) in IABP patients (relative risk 0.87, 95% confidence interval 0.47\u20131.59, P\u2009=\u20090.65). MACCE occurred in 12\/24 (50%) of the pMCS patients vs. 19\/24 (79%) of the IABP patients (P\u2009=\u20090.07). All survivors except for one were in New York Heart Association Class I\/II [pMCS n\u2009=\u200910 (91%) and IABP n\u2009=\u20097 (100%), P\u2009=\u20091.00] and none of the patients had residual angina. There were no differences in left ventricular ejection fraction between the groups (pMCS 52\u2009\u00b1\u200911% vs. IABP 48\u2009\u00b1\u200910%, P\u2009=\u20090.53).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this explorative randomized trial of patients with severe CS after AMI, there was no difference in long-term 5-year mortality between pMCS and IABP-treated patients, supporting previously published short-term data and in accordance with other long-term CS trials.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuab060","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T19:45:21Z","timestamp":1625687121000},"page":"1009-1015","source":"Crossref","is-referenced-by-count":47,"title":["Long-term 5-year outcome of the randomized IMPRESS in severe shock trial: percutaneous mechanical circulatory support vs. intra-aortic balloon pump in cardiogenic shock after acute myocardial infarction"],"prefix":"10.1093","volume":"10","author":[{"given":"Mina","family":"Karami","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlend","family":"Eriksen","sequence":"additional","affiliation":[{"name":"Department of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar M","family":"Ouweneel","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1703-7921","authenticated-orcid":false,"given":"Bimmer E","family":"Claessen","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"},{"name":"Department of Cardiology, Noordwest Ziekenhuisgroep, Alkmaar, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Marije","family":"Vis","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Baan","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Beijk","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik J S","family":"Packer","sequence":"additional","affiliation":[{"name":"Department of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krischan D","family":"Sjauw","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical Center Leeuwarden, Henri Dunantweg 2, 8934 AD Leeuwarden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Engstrom","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"},{"name":"Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Vlaar","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim K","family":"Lagrand","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose P S","family":"Henriques","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"2021120621325421200_zuab060-B1","doi-asserted-by":"crossref","first-page":"i31","DOI":"10.1093\/ejcts\/ezy444","article-title":"Current perspectives on mechanical circulatory support","volume":"55","author":"Schramm","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"2021120621325421200_zuab060-B2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0140-6736(20)31047-3","article-title":"Temporary circulatory support for cardiogenic 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cardiogenic shock","volume":"139","author":"Schrage","year":"2019","journal-title":"Circulation"},{"key":"2021120621325421200_zuab060-B9","doi-asserted-by":"crossref","first-page":"e0235762","DOI":"10.1371\/journal.pone.0235762","article-title":"Pre-PCI versus immediate post-PCI Impella initiation in acute myocardial infarction complicated by cardiogenic shock","volume":"15","author":"Hemradj","year":"2020","journal-title":"PLoS One"},{"key":"2021120621325421200_zuab060-B10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijcard.2020.09.044","article-title":"Short term outcomes of Impella in cardiogenic shock: a review and meta-analysis of observational studies","volume":"324","author":"Iannaccone","year":"2021","journal-title":"Int J Cardiol"},{"key":"2021120621325421200_zuab060-B11","doi-asserted-by":"crossref","first-page":"e006462","DOI":"10.1161\/JAHA.117.006462","article-title":"Left ventricular unloading using an Impella CP improves coronary flow and infarct 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