{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:31:12Z","timestamp":1769693472771,"version":"3.49.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Assistance Publique\u2014H\u00f4pitaux de Paris"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The role of diuretics in patients with intermediate-risk pulmonary embolism (PE) is controversial. In this multicentre, double-blind trial, we randomly assigned normotensive patients with intermediate-risk PE to receive either a single 80\u2009mg bolus of furosemide or a placebo.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Eligible patients had at least a simplified PE Severity Index (sPESI) \u22651 with right ventricular dysfunction. The primary efficacy endpoint assessed 24\u2009h after randomization included (i) absence of oligo-anuria and (ii) normalization of all sPESI items. Safety outcomes were worsening renal function and major adverse outcomes at 48\u2009hours defined by death, cardiac arrest, mechanical ventilation, or need of catecholamine. A total of 276 patients underwent randomization; 135 were assigned to receive the diuretic, and 141 to receive the placebo. The primary outcome occurred in 68\/132 patients (51.5%) in the diuretic and in 49\/132 (37.1%) in the placebo group (relative risk\u2009=\u20091.30, 95% confidence interval 1.04\u20131.61; P\u2009=\u20090.021). Major adverse outcome at 48\u2009h occurred in 1 (0.8%) patients in the diuretic group and 4 patients (2.9%) in the placebo group (P\u2009=\u20090.19). Increase in serum creatinine level was greater in diuretic than placebo group [+4\u2009\u00b5M\/L (\u22122; 14) vs. \u22121\u2009\u00b5M\/L (\u221211; 6), P\u2009&amp;lt;\u20090.001].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In normotensive patients with intermediate-risk PE, a single bolus of furosemide improved the primary efficacy outcome at 24\u2009h and maintained stable renal function. In the furosemide group, urine output increased, without a demonstrable improvement in heart rate, systolic blood pressure, or arterial oxygenation.<\/jats:p>\n                  <jats:p>ClinicalTrials.gov identifier NCT02268903.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuab082","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T19:16:34Z","timestamp":1631819794000},"page":"2-9","source":"Crossref","is-referenced-by-count":19,"title":["Diuretic vs. placebo in intermediate-risk acute pulmonary embolism: a randomized clinical trial"],"prefix":"10.1093","volume":"11","author":[{"given":"Pascal","family":"Lim","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Est Creteil, INSERM, IMRB, Creteil F-94010, France"},{"name":"Department of Cardiology, AP-HP H\u00f4pitaux Universitaires Henri-Mondor, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9ment","family":"Delmas","sequence":"additional","affiliation":[{"name":"Cardiology Department, CHU Rangueil, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-8391","authenticated-orcid":false,"given":"Olivier","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Paris, France"},{"name":"Division of Respiratory and Intensive Care, AP-HP, H\u00f4pital Europ\u00e8en Georges Pompidou, Paris, France"},{"name":"INSERM UMR-S 1140, Innovative Therapies in Haemostasis, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Meneveau","sequence":"additional","affiliation":[{"name":"Cardiology Department, Besancon University Hospital, EA3920, University of Burgundy Franche-Comt\u00e9, Besancon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Rosario","sequence":"additional","affiliation":[{"name":"Cardiology Department, H\u00f4pital Saint-Joseph, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Bouvaist","sequence":"additional","affiliation":[{"name":"Cardiology Department, CHU, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Bernard","sequence":"additional","affiliation":[{"name":"Cardiology Department, CHU, Tours, France and EA4245, Universit\u00e9 de Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Mansourati","sequence":"additional","affiliation":[{"name":"Respiratory Department, CHRU de la Cavale Blanche, Brest, France and University Hospital of Brest and UBO (Universit\u00e9 de Bretagne 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France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Gallet","sequence":"additional","affiliation":[{"name":"Emergency Department, CHRU Lapeyronie, Montpellier, France"},{"name":"Department of Cardiology, AP-HP H\u00f4pitaux Universitaires Henri-Mondor, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Luc","family":"Dubois-Rande","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Creteil, INSERM, IMRB, Creteil F-94010, France"},{"name":"Department of Cardiology, AP-HP H\u00f4pitaux Universitaires Henri-Mondor, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Fard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Creteil, INSERM, IMRB, Creteil F-94010, France"},{"name":"Department of Cardiology, AP-HP H\u00f4pitaux Universitaires Henri-Mondor, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Chatelier","sequence":"additional","affiliation":[{"name":"Clinical Research Department, AP-HP, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tabassome","family":"Simon","sequence":"additional","affiliation":[{"name":"Cinical Pharmacology, AP-HP, H\u00f4pital Saint-Antoine, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Paul","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Creteil, INSERM, IMRB, Creteil F-94010, France"},{"name":"AP-HP H\u00f4pitaux Universitaires Henri-Mondor, Clinical Pharmacology, Cr\u00e9teil F-94010, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Andr\u00e9","family":"Natella","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Creteil, INSERM, IMRB, Creteil F-94010, 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