{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:40:22Z","timestamp":1790502022352,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Age and sex disparities in out-of-hospital cardiac arrest (OHCA) have been described. Reproductive age may have a protected effect on females vs. males, although results are conflicting. We aimed to clarify this using the Paris Sudden Death Expertise Centre (SDEC) registry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The Paris SDEC registry collects OHCAs occurring in the Greater Paris Area. We included all OHCAs of presumed cardiac causes occurring between 2013 and 2018. Patients were divided into age groups: 1\u201313, 13\u201350, 50\u201375, and &amp;gt;75\u2009years. Sex and age disparities in OHCA incidence and outcomes were analysed using multivariable negative binomial and logistic regression models. There were 19\u2009782 OHCAs meeting inclusion criteria: 0.37% aged 1\u201313\u2009years, 12.4% aged 13\u201350\u2009years, 40.4% aged 50\u201375\u2009years, and 46.9% aged &amp;gt;75\u2009years. Adjusted incidence rate ratios (IRRs) in females vs. males were for the youngest to the older age groups: 1.29 [95% confidence interval (CI) 0.78\u20132.13], 0.54 [0.49\u20130.59], 0.60 [0.56\u20130.64], and 0.75 [0.67\u20130.84]. At reproductive age, females were more likely than males to have a return of spontaneous circulation [adjusted odds ratio (OR) 1.60 (1.27\u20132.02)], to be alive at hospital admission [OR: 1.49 (1.18\u20131.89)]. In both sexes, patients aged 13\u201350\u2009years were more likely to survive at hospital discharge than those aged 50\u201375\u2009years [males: OR 1.81 (1.49\u20132.20), females: 2.24 (1.54\u20133.25)]. However, at reproductive age, no sex disparity was observed in survival at hospital discharge [OR: 1.16 (0.75\u20131.80)].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Incidence rate ratios were similar between pre- and post-menopausal aged patients. At reproductive age, no sex disparity in survival at hospital discharge was observed, suggesting that menopausal status may not influence OHCA occurrence and prognosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuac028","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T12:32:28Z","timestamp":1647520348000},"page":"293-302","source":"Crossref","is-referenced-by-count":2,"title":["Does age influence out-of-hospital cardiac arrest incidence and outcomes among women? Insights from the Paris SDEC"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9022-0450","authenticated-orcid":false,"given":"Delphine","family":"Lavignasse","sequence":"first","affiliation":[{"name":"Paris Cardiovascular Research Center, University of Paris, INSERM Unit 970 , 56 Leblanc street, 75015\u00a0Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4018-0715","authenticated-orcid":false,"given":"Sabine","family":"Lemoine","sequence":"additional","affiliation":[{"name":"Brigade des Sapeurs-Pompiers de Paris (BSPP) , 1 place Jules Renard, 75017 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Karam","sequence":"additional","affiliation":[{"name":"Paris Cardiovascular Research Center, University of Paris, INSERM Unit 970 , 56 Leblanc street, 75015\u00a0Paris , France"},{"name":"Department of Cardiology, European Georges Pompidou Hospital, APHP , 20 Leblanc street, 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5516-4665","authenticated-orcid":false,"given":"Bamba","family":"Gaye","sequence":"additional","affiliation":[{"name":"Paris Cardiovascular Research Center, University of Paris, INSERM Unit 970 , 56 Leblanc street, 75015\u00a0Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1821-7713","authenticated-orcid":false,"given":"Wulfran","family":"Bougouin","sequence":"additional","affiliation":[{"name":"Paris Cardiovascular Research Center, University of Paris, INSERM Unit 970 , 56 Leblanc street, 75015\u00a0Paris , France"},{"name":"Medical Surgical Intensive Care Unit, Ramsay G\u00e9n\u00e9rale de Sant\u00e9, H\u00f4pital Priv\u00e9 Jacques Cartier , 6 Noyer Lambert avenue, 91300 Massy , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-224X","authenticated-orcid":false,"given":"Frankie","family":"Beganton","sequence":"additional","affiliation":[{"name":"Paris Cardiovascular Research Center, University of Paris, INSERM Unit 970 , 56 Leblanc street, 75015\u00a0Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-6669","authenticated-orcid":false,"given":"Patricia","family":"Jabre","sequence":"additional","affiliation":[{"name":"Paris Cardiovascular Research Center, University of Paris, INSERM Unit 970 , 56 Leblanc street, 75015\u00a0Paris , France"},{"name":"Emergency Medical Services, SAMU 75, Necker Enfants Malades Hospital , APHP, 11 rue de S\u00e8vres, 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Loeb","sequence":"additional","affiliation":[{"name":"Emergency Medical Services, SAMU 92, Raymond Poincar\u00e9 Hospital , APHP, 104, Raymond-Poincar\u00e9 boulevard, 92380 Garches , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5622-7026","authenticated-orcid":false,"given":"Jean-Marc","family":"Agostinucci","sequence":"additional","affiliation":[{"name":"Emergency Medical Services, SAMU 93, H\u00f4pital Avicenne, APHP , 125 Stalingrad street, 93000 Bobigny , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7651-7909","authenticated-orcid":false,"given":"Florence","family":"Dumas","sequence":"additional","affiliation":[{"name":"Paris Cardiovascular Research Center, University of Paris, INSERM Unit 970 , 56 Leblanc street, 75015\u00a0Paris , France"},{"name":"Emergency Department, Cochin-Hotel-Dieu Hospital, APHP , 27 Faubourg Saint-Jacques, street 75014 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5333-822X","authenticated-orcid":false,"given":"Eric","family":"Lecarpentier","sequence":"additional","affiliation":[{"name":"Emergency Medical Services, SAMU 94, Henri Mondor Hospital , APHP, 1 Gustave Eiffel street, 94000 Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6046-1234","authenticated-orcid":false,"given":"Daniel","family":"Jost","sequence":"additional","affiliation":[{"name":"Department of Cardiology, European Georges Pompidou Hospital, APHP , 20 Leblanc street, 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3258-4672","authenticated-orcid":false,"given":"Alain","family":"Cariou","sequence":"additional","affiliation":[{"name":"Paris Cardiovascular Research Center, University of Paris, INSERM Unit 970 , 56 Leblanc street, 75015\u00a0Paris , France"},{"name":"Medical Intensive Care Unit, H\u00f4pital Cochin Hospital , APHP, 27 Faubourg Saint-Jacques, street,75014 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7227-3428","authenticated-orcid":false,"given":"Eloi","family":"Marijon","sequence":"additional","affiliation":[{"name":"Paris Cardiovascular Research Center, University of Paris, INSERM Unit 970 , 56 Leblanc street, 75015\u00a0Paris , France"},{"name":"Department of Cardiology, European Georges Pompidou Hospital, APHP , 20 Leblanc street, 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-7772","authenticated-orcid":false,"given":"Jean-Philippe","family":"Empana","sequence":"additional","affiliation":[{"name":"Paris Cardiovascular Research Center, University of Paris, INSERM Unit 970 , 56 Leblanc street, 75015\u00a0Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Jouven","sequence":"additional","affiliation":[{"name":"Paris Cardiovascular Research Center, University of Paris, INSERM Unit 970 , 56 Leblanc street, 75015\u00a0Paris , France"},{"name":"Department of Cardiology, European Georges Pompidou Hospital, APHP , 20 Leblanc street, 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"2022060717500142300_zuac028-B1","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1001\/jama.288.23.3008","article-title":"Changing incidence of out-of-hospital ventricular fibrillation, 1980\u20132000","volume":"288","author":"Cobb","year":"2002","journal-title":"JAMA"},{"key":"2022060717500142300_zuac028-B2","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1161\/hc4701.099784","article-title":"Out-of-hospital cardiac arrest in men and women","volume":"104","author":"Kim","year":"2001","journal-title":"Circulation"},{"key":"2022060717500142300_zuac028-B3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/euhj.1999.1629","article-title":"Sex differences in outcome following community-based cardiopulmonary arrest","volume":"21","author":"Pell","year":"2000","journal-title":"Eur Heart J"},{"key":"2022060717500142300_zuac028-B4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.resuscitation.2015.06.018","article-title":"Gender and survival after sudden cardiac arrest: a systematic review and meta-analysis","volume":"94","author":"Bougouin","year":"2015","journal-title":"Resuscitation"},{"key":"2022060717500142300_zuac028-B5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.118.004710","article-title":"Gender Disparities Among Adult Recipients of Bystander Cardiopulmonary Resuscitation in the Public","volume":"11","author":"Blewer","year":"2018","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2022060717500142300_zuac028-B6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1161\/CIRCULATIONAHA.120.050427","article-title":"Gender-based differences in outcomes among resuscitated patients with out-of-hospital cardiac arrest","volume":"143","author":"Mody","year":"2021","journal-title":"Circulation"},{"key":"2022060717500142300_zuac028-B7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0300-9572(99)00155-0","article-title":"Incidence, duration and survival of ventricular fibrillation in out-of-hospital cardiac arrest patients in Sweden","volume":"44","author":"Holmberg","year":"2000","journal-title":"Resuscitation"},{"key":"2022060717500142300_zuac028-B8","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1161\/CIRCULATIONAHA.111.076810","article-title":"Incidence, causes, and survival trends from cardiovascular-related sudden cardiac arrest in children and young adults 0 to 35 years of age: a 30-year review","volume":"126","author":"Meyer","year":"2012","journal-title":"Circulation"},{"key":"2022060717500142300_zuac028-B9","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1161\/CIRCULATIONAHA.114.013122","article-title":"Survival after out-of-hospital cardiac arrest in relation to age and early identification of patients with minimal chance of long-term survival","volume":"131","author":"Wissenberg","year":"2015","journal-title":"Circulation"},{"key":"2022060717500142300_zuac028-B10","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1093\/eurheartj\/ehz297","article-title":"Women have lower chances than men to be resuscitated and survive out-of-hospital cardiac arrest","volume":"40","author":"Blom","year":"2019","journal-title":"Eur Heart J"},{"key":"2022060717500142300_zuac028-B11","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/eurheartj\/ehq059","article-title":"Reduction in incidence and fatality of out-of-hospital cardiac arrest in females of the reproductive age","volume":"31","author":"Kitamura","year":"2010","journal-title":"Eur Heart J"},{"key":"2022060717500142300_zuac028-B12","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.resuscitation.2012.12.004","article-title":"Exploring gender differences and the \u2018oestrogen effect\u2019 in an Australian out-of-hospital cardiac arrest population","volume":"84","author":"Bray","year":"2013","journal-title":"Resuscitation"},{"key":"2022060717500142300_zuac028-B13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/2048872616633879","article-title":"Resuscitation outcomes of reproductive-age females who experienced out-of-hospital cardiac arrest","volume":"6","author":"Hagihara","year":"2017","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"2022060717500142300_zuac028-B14","doi-asserted-by":"crossref","first-page":"100084","DOI":"10.1016\/j.resplu.2021.100084","article-title":"The effect of sex and age on return of spontaneous circulation and survival to hospital discharge in patients with out of hospital cardiac arrest: a retrospective analysis of a Canadian population","volume":"5","author":"Awad","year":"2021","journal-title":"Resusc Plus"},{"key":"2022060717500142300_zuac028-B15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.resuscitation.2021.06.024","article-title":"Premenopausal-aged females have no neurological outcome advantage after out-of-hospital cardiac arrest: a multilevel analysis of North American populations","volume":"166","author":"Awad","year":"2021","journal-title":"Resuscitation"},{"key":"2022060717500142300_zuac028-B16","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.amjcard.2017.05.003","article-title":"Age \u00d7 gender interaction effect on resuscitation outcomes in patients with out-of-hospital cardiac arrest","volume":"120","author":"Hagihara","year":"2017","journal-title":"Am J Cardiol"},{"key":"2022060717500142300_zuac028-B17","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.resuscitation.2012.09.011","article-title":"Females of childbearing age have a survival benefit after out-of-hospital cardiac arrest","volume":"84","author":"Johnson","year":"2013","journal-title":"Resuscitation"},{"key":"2022060717500142300_zuac028-B18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.resuscitation.2015.12.002","article-title":"Effect of gender on outcome of out of hospital cardiac arrest in the Resuscitation Outcomes Consortium","volume":"100","author":"Morrison","year":"2016","journal-title":"Resuscitation"},{"key":"2022060717500142300_zuac028-B19","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s00134-014-3252-5","article-title":"Characteristics and prognosis of sudden cardiac death in Greater Paris: population-based approach from the Paris Sudden Death Expertise Center (Paris\u2014SDEC)","volume":"40","author":"Bougouin","year":"2014","journal-title":"Intensive Care Med"},{"key":"2022060717500142300_zuac028-B20","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1161\/CIR.0000000000000144","article-title":"Cardiac arrest and cardiopulmonary resuscitation outcome reports: update of the Utstein Resuscitation Registry templates for out-of-hospital cardiac arrest","volume":"132","author":"Perkins","year":"2015","journal-title":"Circulation"},{"key":"2022060717500142300_zuac028-B21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.gyobfe.2010.01.014","article-title":"[Age at onset of menarche: Results from the French Health Behaviour in School-aged Children study]","volume":"38","author":"Gaudineau","year":"2010","journal-title":"Gynecol Obstet Fertil"},{"key":"2022060717500142300_zuac028-B22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/aje\/kws421","article-title":"Factors related to age at natural menopause: longitudinal analyses from SWAN","volume":"178","author":"Gold","year":"2013","journal-title":"Am J Epidemiol"},{"key":"2022060717500142300_zuac028-B23","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1093\/eurheartj\/ehw106","article-title":"2016 European Guidelines on cardiovascular disease prevention in clinical practice: the Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)","volume":"37","author":"Piepoli","year":"2016","journal-title":"Eur Heart J"},{"key":"2022060717500142300_zuac028-B24","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1177\/2047487316667784","article-title":"Lifestyle and risk factor management in people at high risk of cardiovascular disease. A report from the European Society of Cardiology European Action on Secondary and Primary Prevention by Intervention to Reduce Events (EUROASPIRE) IV cross-sectional survey in 14 European regions","volume":"23","author":"Kotseva","year":"2016","journal-title":"Eur J Prev Cardiol"},{"key":"2022060717500142300_zuac028-B25","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1093\/eurheartj\/ehi376","article-title":"Diabetes, glucose level, and risk of sudden cardiac death","volume":"26","author":"Jouven","year":"2005","journal-title":"Eur Heart J"},{"key":"2022060717500142300_zuac028-B26","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/HJR.0b013e328325d7f0","article-title":"Sex-based differences in premature first myocardial infarction caused by smoking: twice as many years lost by women as by men","volume":"16","author":"Grundtvig","year":"2009","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"2022060717500142300_zuac028-B27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.resuscitation.2019.05.018","article-title":"Socio-economic differences in incidence, bystander cardiopulmonary resuscitation and survival from out-of-hospital cardiac arrest: a systematic review","volume":"141","author":"van Nieuwenhuizen","year":"2019","journal-title":"Resuscitation"},{"key":"2022060717500142300_zuac028-B28","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1161\/CIRCULATIONAHA.118.036553","article-title":"Racial differences in sudden cardiac death","volume":"139","author":"Zhao","year":"2019","journal-title":"Circulation"},{"key":"2022060717500142300_zuac028-B29","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003704","article-title":"Sex-Based Disparities in Incidence, Treatment, and Outcomes of Cardiac Arrest in the United States, 2003-2012","volume":"5","author":"Kim","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"2022060717500142300_zuac028-B30","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1056\/NEJM199308263290902","article-title":"Racial differences in the incidence of cardiac arrest and subsequent survival. The CPR Chicago Project","volume":"329","author":"Becker","year":"1993","journal-title":"N Engl J Med"}],"container-title":["European Heart Journal. Acute Cardiovascular Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/11\/4\/293\/43973109\/zuac028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/11\/4\/293\/43973109\/zuac028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T17:51:43Z","timestamp":1654624303000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjacc\/article\/11\/4\/293\/6567697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,13]]},"published-print":{"date-parts":[[2022,6,7]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjacc\/zuac028","relation":{},"ISSN":["2048-8726","2048-8734"],"issn-type":[{"value":"2048-8726","type":"print"},{"value":"2048-8734","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,4,1]]},"published":{"date-parts":[[2022,4,1]]}}}