{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:59:42Z","timestamp":1790135982908,"version":"4.0.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministry of Economy and Competitiveness","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Instituto Carlos III","award":["PI20\/00392"],"award-info":[{"award-number":["PI20\/00392"]}]},{"name":"CIBER Cardiovascular","award":["16\/11\/00420"],"award-info":[{"award-number":["16\/11\/00420"]}]},{"name":"CIBER Cardiovascular","award":["16\/11\/00403"],"award-info":[{"award-number":["16\/11\/00403"]}]},{"DOI":"10.13039\/100009664","name":"Spanish Society of Cardiology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009664","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Spanish Society of Internal Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Increased intra-abdominal pressure (IAP) is now considered a potential contributor to organ damage and disease progression in acute heart failure (AHF). In this work, we aimed to determine if antigen carbohydrate 125 (CA125) is associated with IAP and to identify a cutpoint of CA125 useful for ruling out intra-abdominal hypertension (defined as IAP\u2009\u2265\u200912\u2005mmHg).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We prospectively evaluated a cohort of 53 patients admitted with AHF in which IAP was measured within the first 24-h of admission. The mean age was 80\u2009\u00b1\u20098 years, 31 (58.5%) were female, and 31 (58.5%) had left ventricular ejection fraction \u226550%. The median plasma levels of NT-proBNP and CA125 were 3830\u2005pg\/mL (2417\u20138929) and 45.8\u2005U\/mL (29.8\u2013114.0), respectively. The median of IAP was 15\u2005mmHg (11\u201317), and 39 (73%) patients had an IAP\u2009\u2265\u200912\u2005mmHg. The diagnostic performance of CA125 for identifying an IAP\u2009\u2265\u200912\u2005mmHg was tested using the receiving operating characteristic (ROC) curve. The cut-off for CA125 of 17.1\u2005U\/mL showed a sensitivity of 92%, a specificity of 50%, and an area under the ROC curve of 0.71. After multivariate adjustment, CA125 remained non-linearly and positively associated with higher IAP (P-value\u2009=\u20090.003), explaining almost 28% of the model\u2019s variability (R2: 27.6%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with AHF and intra-abdominal hypertension had higher CA125 plasma levels. A baseline concentration of CA125 below 17.1\u2005U\/mL will increase the odds of identifying a subset of patients with normal IAP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuac046","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T11:12:38Z","timestamp":1649934758000},"page":"453-460","source":"Crossref","is-referenced-by-count":5,"title":["Utility of plasma CA125 as a proxy of intra-abdominal pressure in patients with acute heart failure"],"prefix":"10.1093","volume":"11","author":[{"given":"Jorge","family":"Rubio-Gracia","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Hospital Cl\u00ednico Universitario \u2018Lozano Blesa\u2019 , Avda. San Juan Bosco no 15, 50009 Zaragoza , Spain"},{"name":"Instituto Investigaci\u00f3n Sanitaria Arag\u00f3n , Zaragoza , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Crespo-Aznarez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Cl\u00ednico Universitario \u2018Lozano Blesa\u2019 , Avda. San Juan Bosco no 15, 50009 Zaragoza , Spain"},{"name":"Instituto Investigaci\u00f3n Sanitaria Arag\u00f3n , Zaragoza , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"De la Espriella","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario de Valencia, INCLIVA, Departamento de Medicina, Universitat de Val\u00e8ncia , Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario de Valencia, INCLIVA, Departamento de Medicina, Universitat de Val\u00e8ncia , Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"S\u00e1nchez-Marteles","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Cl\u00ednico Universitario \u2018Lozano Blesa\u2019 , Avda. San Juan Bosco no 15, 50009 Zaragoza , Spain"},{"name":"Instituto Investigaci\u00f3n Sanitaria Arag\u00f3n , Zaragoza , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Garc\u00e9s-Horna","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Cl\u00ednico Universitario \u2018Lozano Blesa\u2019 , Avda. San Juan Bosco no 15, 50009 Zaragoza , Spain"},{"name":"Instituto Investigaci\u00f3n Sanitaria Arag\u00f3n , Zaragoza , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Yanguas-Barea","sequence":"additional","affiliation":[{"name":"Radiology Department, Hospital Cl\u00ednico Universitario \u2018Lozano Blesa\u2019 , Zaragoza , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Josa-Laorden","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Cl\u00ednico Universitario \u2018Lozano Blesa\u2019 , Avda. San Juan Bosco no 15, 50009 Zaragoza , Spain"},{"name":"Instituto Investigaci\u00f3n Sanitaria Arag\u00f3n , Zaragoza , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cobo-Marcos","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Puerta de Hierro , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Gim\u00e9nez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Instituto Investigaci\u00f3n Sanitaria Arag\u00f3n , Zaragoza , Spain"},{"name":"Facultad de Medicina, Universidad de Zaragoza , Zaragoza , Spain"},{"name":"Instituto Aragon\u00e9s de Ciencias de la Salud (IACS) , Zaragoza , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Ignacio","family":"P\u00e9rez-Calvo","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Cl\u00ednico Universitario \u2018Lozano Blesa\u2019 , Avda. San Juan Bosco no 15, 50009 Zaragoza , Spain"},{"name":"Instituto Investigaci\u00f3n Sanitaria Arag\u00f3n , Zaragoza , Spain"},{"name":"Facultad de Medicina, Universidad de Zaragoza , Zaragoza , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario de Valencia, INCLIVA, Departamento de Medicina, Universitat de Val\u00e8ncia , Valencia , Spain"},{"name":"CIBER in Cardiovascular Diseases (CIBERCV) , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"2022062217490990800_zuac046-B1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jacc.2013.04.070","article-title":"Abdominal contributions to cardiorenal dysfunction in congestive heart failure","volume":"62","author":"Verbrugge","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2022062217490990800_zuac046-B2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/clc.22489","article-title":"Intra-abdominal hypertension: an important consideration for diuretic resistance in acute decompensated heart failure","volume":"39","author":"Nguyen","year":"2016","journal-title":"Clin Cardiol"},{"key":"2022062217490990800_zuac046-B3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.5603\/AIT.2014.0063","article-title":"The role of abdominal compliance, the neglected parameter in critically ill patients\u2014a consensus review of 16. Part 2: measurement techniques and management recommendations","volume":"46","author":"Malbrain","year":"2014","journal-title":"Anaesthesiol Intensive Ther"},{"key":"2022062217490990800_zuac046-B4","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/ki.2012.406","article-title":"The relevance of congestion in the cardio-renal syndrome","volume":"83","author":"Gnanaraj","year":"2013","journal-title":"Kidney Int"},{"key":"2022062217490990800_zuac046-B5","first-page":"35","article-title":"Congestion in heart failure, a prominent role in pathophysiology, and a therapeutic goal","volume":"1","author":"Rubio-gracia","year":"2021","journal-title":"Spanish J Med"},{"key":"2022062217490990800_zuac046-B6","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s00380-020-01634-9","article-title":"Intra-abdominal pressure and its relationship with markers of congestion in patients admitted for acute decompensated heart failure","volume":"35","author":"Rubio-Gracia","year":"2020","journal-title":"Heart Vessels"},{"key":"2022062217490990800_zuac046-B7","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.cardfail.2008.02.010","article-title":"Prompt reduction in intra-abdominal pressure following large-volume mechanical fluid removal improves renal insufficiency in refractory decompensated heart failure","volume":"14","author":"Mullens","year":"2008","journal-title":"J Card Fail"},{"key":"2022062217490990800_zuac046-B8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/ckj\/sfv124","article-title":"Focus on renal congestion in heart failure","volume":"9","author":"Afsar","year":"2016","journal-title":"Clin Kidney J"},{"key":"2022062217490990800_zuac046-B9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/ehf2.13118","article-title":"Congestive nephropathy: a neglected entity? Proposal for diagnostic criteria and future perspectives","volume":"8","author":"Husain-Syed","year":"2021","journal-title":"ESC Hear Fail"},{"key":"2022062217490990800_zuac046-B10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.20452\/pamw.4290","article-title":"Validation of transurethral intra-abdominal pressure measurement in acute heart failure","volume":"128","author":"Zymli\u0144ski","year":"2018","journal-title":"Polish Arch Intern Med"},{"key":"2022062217490990800_zuac046-B11","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1007\/s00134-006-0349-5","article-title":"Results from the international conference of experts on intra-abdominal hypertension and abdominal compartment syndrome. I. Definitions","volume":"32","author":"Malbrain","year":"2006","journal-title":"Intensive Care Med"},{"key":"2022062217490990800_zuac046-B12","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1186\/2110-5820-2-S1-S10","article-title":"Intra-abdominal pressure measurement using the FoleyManometer does not increase the risk for urinary tract infection in critically ill patients","volume":"2012","author":"Desie","year":"2012","journal-title":"Ann Intensive Care"},{"key":"2022062217490990800_zuac046-B13","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1136\/hrt.2006.096016","article-title":"Carbohydrate antigen 125: an emerging prognostic risk factor in acute heart failure?","volume":"93","author":"N\u00fa\u00f1ez","year":"2007","journal-title":"Heart"},{"key":"2022062217490990800_zuac046-B14","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jchf.2019.12.005","article-title":"Clinical role of CA125 in worsening heart failure: a BIOSTAT-CHF study subanalysis","volume":"8","author":"N\u00fa\u00f1ez","year":"2020","journal-title":"JACC Hear Fail"},{"key":"2022062217490990800_zuac046-B15","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41569-020-0379-7","article-title":"Congestion in heart failure: a contemporary look at physiology, diagnosis and treatment","volume":"17","author":"Boorsma","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"2022062217490990800_zuac046-B16","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/ejhf.2295","article-title":"Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review","volume":"23","author":"N\u00fa\u00f1ez","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"2022062217490990800_zuac046-B17","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.echo.2013.06.004","article-title":"Non-invasive evaluation of right atrial pressure","volume":"26","author":"Beigel","year":"2013","journal-title":"J Am Soc Echocardiogr"},{"key":"2022062217490990800_zuac046-B18","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","article-title":"Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography","volume":"23","author":"Rudski","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"2022062217490990800_zuac046-B19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"2022062217490990800_zuac046-B20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijcard.2018.01.067","article-title":"Prevalence, predictors and clinical outcome of residual congestion in acute decompensated heart failure","volume":"258","author":"Rubio-Gracia","year":"2018","journal-title":"Int J Cardiol"},{"key":"2022062217490990800_zuac046-B21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ejheart.2004.01.011","article-title":"Analytical performance of the N terminal pro B type natriuretic peptide (NT-proBNP) assay on the ElecsysTM 1010 and 2010 analysers","volume":"6","author":"Collinson","year":"2004","journal-title":"Eur J Heart Fail"},{"key":"2022062217490990800_zuac046-B22","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1309\/NBA312W0LANRXYH9","article-title":"Performance characteristics of seven automated CA 125 assays","volume":"125","author":"Mongia","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"2022062217490990800_zuac046-B23","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jacc.2007.09.043","article-title":"Elevated intra-abdominal pressure in acute decompensated heart failure. A potential contributor to worsening renal function?","volume":"51","author":"Mullens","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2022062217490990800_zuac046-B24","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.rceng.2020.01.011","article-title":"Variation in intraabdominal pressure in patients with acute heart failure according to left ventricular ejection fraction. Results of an intraabdominal pressure study","volume":"221","author":"Gracia","year":"2021","journal-title":"Rev Cl\u00ednica Espa\u00f1ola (English Ed)"},{"key":"2022062217490990800_zuac046-B25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.rce.2018.09.022","article-title":"Intraabdominal pressure and worsening renal function during decompensations of heart failure. A preliminary report from the PIA study","volume":"219","author":"Rubio-Gracia","year":"2019","journal-title":"Rev Clin Esp"},{"key":"2022062217490990800_zuac046-B26","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1093\/eurheartj\/ehq142","article-title":"Improvement in risk stratification with the combination of the tumour marker antigen carbohydrate 125 and brain natriuretic peptide in patients with acute heart failure","volume":"31","author":"N\u00fa\u00f1ez","year":"2010","journal-title":"Eur Heart J"},{"key":"2022062217490990800_zuac046-B27","first-page":"1","article-title":"Prognostic value of glycoprotein CA125 and their time-line changes in decompensated heart failure","volume":"1","author":"Josa-laorden","year":"2021","journal-title":"Spanish J Med"},{"key":"2022062217490990800_zuac046-B28","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.amjmed.2019.07.041","article-title":"CA125-guided diuretic treatment versus usual care in patients with acute heart failure and renal dysfunction","volume":"133","author":"N\u00fa\u00f1ez","year":"2020","journal-title":"Am J Med"},{"key":"2022062217490990800_zuac046-B29","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1093\/eurheartj\/ehw008","article-title":"Intestinal congestion and right ventricular dysfunction: a link with appetite loss, inflammation, and cachexia in chronic heart failure","volume":"37","author":"Valentova","year":"2016","journal-title":"Eur Heart J"},{"key":"2022062217490990800_zuac046-B30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/2048872620908033","article-title":"Factors associated with plasma antigen carbohydrate 125 and amino-terminal pro-B-type natriuretic peptide concentrations in acute heart failure","volume":"9","author":"Mi\u00f1ana","year":"2020","journal-title":"Eur Hear J Acute Cardiovasc Care"},{"key":"2022062217490990800_zuac046-B31","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.medcli.2020.05.063","article-title":"Comparison between CA125 and NT-proBNP for evaluating congestion in acute heart failure","volume":"156","author":"Ll\u00e0cer","year":"2021","journal-title":"Med Clin (Barc)"},{"key":"2022062217490990800_zuac046-B32","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/ejhf.1383","article-title":"Prevalence, pattern and clinical relevance of ultrasound indices of congestion in outpatients with heart failure","volume":"21","author":"Pellicori","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2022062217490990800_zuac046-B33","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/ehf2.12598","article-title":"Inferior vena cava ultrasound in acute decompensated heart failure: design rationale of the CAVA-ADHF-DZHK10 trial","volume":"7","author":"Jobs","year":"2020","journal-title":"ESC Hear Fail"}],"container-title":["European Heart Journal. Acute Cardiovascular Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/11\/6\/453\/44171430\/zuac046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/11\/6\/453\/44171430\/zuac046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T17:50:28Z","timestamp":1655920228000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjacc\/article\/11\/6\/453\/6580638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,5,5]]},"published-print":{"date-parts":[[2022,6,22]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjacc\/zuac046","relation":{},"ISSN":["2048-8726","2048-8734"],"issn-type":[{"value":"2048-8726","type":"print"},{"value":"2048-8734","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,6,1]]},"published":{"date-parts":[[2022,5,5]]}}}