{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:17:14Z","timestamp":1787847434017,"version":"build-2784847793"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"CAMS Innovation Fund for Medical Sciences","award":["2021-I2M-1-008"],"award-info":[{"award-number":["2021-I2M-1-008"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2020-I2M-C&T-B-056"],"award-info":[{"award-number":["2020-I2M-C&T-B-056"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To explore the association between elevated cardiac troponin I (cTnI) on 30-day mortality in patients with acute type A aortic dissection (ATAAD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A total of 1321 consecutive patients who were admitted to the emergency department of Fuwai Hospital from January 2016 to December 2020 were enrolled. Patients had computed tomography-confirmed ATAAD and were measured serum cTnI on admission. Patients were divided into the troponin-positive (cTnI &amp;gt; 0.02 ng\/mL) or the troponin-negative group (cTnI \u2264 0.02 ng\/mL). Troponin was detected by PATHFAST instrument produced by Medins Co., Ltd., and the reference range of normal value is 0\u20130.02 ng\/mL. A total of 522 out of 1321 patients (39.5%) in our study had elevated cTnI, who had higher 30\u2013day mortality rate compared with the troponin-negative group (44.4% vs. 19.4% P &amp;lt; 0.0001). Multivariate logistic regression results showed that elevated cTnI was an independent risk indicator for 30-day mortality (odds ratio: 2.582; 95% confidence interval: 1.357\u20134.914; P = 0.0039). The addition of elevated cTnI level to a clinical-based risk prediction model resulted in significant incremental prognostic value (AUC difference: 0.0261).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Elevated cTnI is common in patients with ATAAD, and is associated with increased 30-day mortality risk.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuac070","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T17:58:49Z","timestamp":1659117529000},"page":"597-606","source":"Crossref","is-referenced-by-count":11,"title":["Elevated cardiac troponin I and short-term mortality in patients with acute type A aortic dissection"],"prefix":"10.1093","volume":"11","author":[{"given":"Shuai","family":"Liu","sequence":"first","affiliation":[{"name":"Cardiometabolic Medicine Center, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China"},{"name":"State Key Laboratory of Cardiovascular Disease , A 167, Beilishi Road, Xicheng District, Beijing 100037 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Song","sequence":"additional","affiliation":[{"name":"Cardiometabolic Medicine Center, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China"},{"name":"State Key Laboratory of Cardiovascular Disease , A 167, Beilishi Road, Xicheng District, Beijing 100037 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Bian","sequence":"additional","affiliation":[{"name":"Cardiometabolic Medicine Center, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China"},{"name":"State Key Laboratory of Cardiovascular Disease , A 167, Beilishi Road, Xicheng District, Beijing 100037 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiometabolic Medicine Center, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China"},{"name":"State Key Laboratory of Cardiovascular Disease , A 167, Beilishi Road, Xicheng District, Beijing 100037 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Fu","sequence":"additional","affiliation":[{"name":"Cardiometabolic Medicine Center, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China"},{"name":"State Key Laboratory of Cardiovascular Disease , A 167, Beilishi Road, Xicheng District, Beijing 100037 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiometabolic Medicine Center, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China"},{"name":"State Key Laboratory of Cardiovascular Disease , A 167, Beilishi Road, Xicheng District, Beijing 100037 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Cardiometabolic Medicine Center, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China"},{"name":"State Key Laboratory of Cardiovascular Disease , A 167, Beilishi Road, Xicheng 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