{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:45:42Z","timestamp":1787856342548,"version":"build-2784847793"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Shock severity predicts mortality in patients with cardiogenic shock (CS). We evaluated the association between pre-cannulation Society for Cardiovascular Angiography and Intervention (SCAI) shock classification and mortality among patients receiving venoarterial (VA) extracorporeal membrane oxygenation (ECMO) support for CS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We included Extracorporeal Life Support Organization (ELSO) Registry patients from 2010 to 2020 who received VA ECMO for CS. SCAI shock stage was assigned based on hemodynamic support requirements prior to ECMO initiation. In-hospital mortality was analyzed using multivariable logistic regression. We included 12 106 unique VA ECMO patient runs with a median age of 57.9 (interquartile range: 46.8, 66.1) years and 31.8% were females; 3472 (28.7%) were post-cardiotomy. The distribution of SCAI shock stages at ECMO initiation was: B, 821 (6.8%); C, 7518 (62.1%); D, 2973 (24.6%); and E, 794 (6.6%). During the index hospitalization, 6681 (55.2%) patients died. In-hospital mortality increased incrementally with SCAI shock stage (adjusted OR: 1.24 per SCAI shock stage, 95% CI: 1.17\u20131.32, P &amp;lt; 0.001): B, 47.5%; C, 52.8%; D, 60.8%; E, 65.1%. A higher SCAI shock stage was associated with increased in-hospital mortality in key subgroups, although the SCAI shock classification was only predictive of mortality in non-surgical (medical) CS and not in post-cardiotomy CS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The severity of shock prior to cannulation is a strong predictor of in-hospital mortality in patients receiving VA ECMO for CS. Using the pre-cannulation SCAI shock classification as a risk stratification tool can help clinicians refine prognostication for ECMO recipients and guide future investigations to improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuac119","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T17:06:59Z","timestamp":1664298419000},"page":"891-903","source":"Crossref","is-referenced-by-count":32,"title":["Cardiogenic shock severity and mortality in patients receiving venoarterial extracorporeal membrane oxygenator support"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-2859","authenticated-orcid":false,"given":"Jacob C","family":"Jentzer","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine , Mayo Clinic, 200 First Street SW, Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7754-9953","authenticated-orcid":false,"given":"David A","family":"Baran","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute , Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL 33331 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kyle Bohman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine , Mayo Clinic, 200 First Street SW, Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-828X","authenticated-orcid":false,"given":"Sean","family":"van Diepen","sequence":"additional","affiliation":[{"name":"Extracorporeal Life Support Organization (ELSO) , ELSO Office, 3001 Miller Road, Ann Arbor, MI 48103 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misty","family":"Radosevich","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine , Mayo Clinic, 200 First Street SW, Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraj","family":"Yalamuri","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine , Mayo Clinic, 200 First Street SW, Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rycus","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine and Division of Cardiology, Department of Medicine, University of Alberta , 8440 112 St NW, Edmonton, AB T6G 2B7 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros G","family":"Drakos","sequence":"additional","affiliation":[{"name":"Divisions of Cardiothoracic Surgery and Emergency Medicine, University of Utah Hospital , 50 Medical Dr N, Salt Lake City, UT 84132 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E","family":"Tonna","sequence":"additional","affiliation":[{"name":"Divisions of Cardiothoracic Surgery and Emergency Medicine, University of Utah Hospital , 50 Medical Dr N, Salt Lake City, UT 84132 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"2026071702014580000_zuac119-B1","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1161\/CIR.0000000000000525","article-title":"Contemporary management of cardiogenic shock: a scientific statement from the American heart association","volume":"136","author":"van Diepen","year":"2017","journal-title":"Circulation"},{"key":"2026071702014580000_zuac119-B2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ahj.2020.10.054","article-title":"Shock in the cardiac intensive care unit: changes in epidemiology and prognosis over time","volume":"232","author":"Jentzer","year":"2021","journal-title":"Am Heart J"},{"key":"2026071702014580000_zuac119-B3","article-title":"Variability in reporting of key outcome predictors in acute myocardial infarction cardiogenic shock trials","volume":"99","author":"Tyler","year":"2022","journal-title":"Catheter Cardiovasc Interv"},{"key":"2026071702014580000_zuac119-B4","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.jacc.2015.02.043","article-title":"2015. 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