{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:14:55Z","timestamp":1762377295008,"version":"3.37.3"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01HL148439"],"award-info":[{"award-number":["R01HL148439"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>PARADISE-MI examined the efficacy of sacubitril\/valsartan in acute myocardial infarction (AMI) complicated by reduced left ventricular ejection fraction (LVEF), pulmonary congestion, or both. We sought to assess the trajectory of pulmonary congestion using lung ultrasound (LUS) and its association with cardiac structure and function in a pre-specified substudy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Patients without prior heart failure (HF) underwent eight-zone LUS and echocardiography at baseline (\u00b12 days of randomization) and after 8 months. B-lines were quantified offline, blinded to treatment, clinical findings, time point, and outcomes. Among 152 patients (median age 65, 32% women, mean LVEF 41%), B-lines were detectable in 87% at baseline [median B-line count: 4 (interquartile range 2\u20138)]. Among 115 patients with LUS data at baseline and follow-up, B-lines decreased significantly from baseline (mean \u00b1 standard deviation: \u22121.6 \u00b1 7.3; P = 0.018). The proportion of patients without pulmonary congestion at follow-up was significantly higher in those with fewer B-lines at baseline. Adjusted for baseline, B-lines at follow-up were on average 6 (95% confidence interval: 3\u20139) higher in patients who experienced an intercurrent HF event vs. those who did not (P = 0.001). A greater number of B-lines at baseline was associated with larger left atrial size, higher E\/e\u2032 and E\/A ratios, greater degree of mitral regurgitation, worse right ventricular systolic function, and higher tricuspid regurgitation velocity (P-trend &amp;lt;0.05 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this AMI cohort, B-lines, indicating pulmonary congestion, were common at baseline and, on average, decreased significantly from baseline to follow-up. Worse pulmonary congestion was associated with prognostically important echocardiographic markers.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ehjacc\/zuad001","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T04:02:20Z","timestamp":1674014540000},"page":"155-164","source":"Crossref","is-referenced-by-count":3,"title":["Trajectory and correlates of pulmonary congestion by lung ultrasound in patients with acute myocardial infarction: insights from PARADISE-MI"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8604-0710","authenticated-orcid":false,"given":"Elke","family":"Platz","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 360 Longwood Ave, 7th Floor, Boston, MA 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Claggett","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 360 Longwood Ave, 7th Floor, Boston, MA 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karola S","family":"Jering","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 360 Longwood Ave, 7th Floor, Boston, MA 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University , Budapest , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Cikes","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, University of Zagreb School of Medicine and University Hospital Centre Zagreb , Zagreb , Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ephraim B","family":"Winzer","sequence":"additional","affiliation":[{"name":"Heart Center Dresden\u2014University Clinic, Department of Internal Medicine and Cardiology, Technische Universit\u00e4t Dresden , Dresden , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aria","family":"Rad","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 360 Longwood Ave, 7th Floor, Boston, MA 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin P","family":"Lefkowitz","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceutical Corporation , East Hanover, NJ , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjian","family":"Gong","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceutical Corporation , East Hanover, NJ , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-1466","authenticated-orcid":false,"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Blegdamsvej, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J V","family":"McMurray","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow , Glasgow , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3698-9597","authenticated-orcid":false,"given":"Scott D","family":"Solomon","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 360 Longwood Ave, 7th Floor, Boston, MA 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A","family":"Pfeffer","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 360 Longwood Ave, 7th Floor, Boston, MA 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amil","family":"Shah","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital , 360 Longwood Ave, 7th Floor, Boston, MA 02115 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"2023070503375473000_zuad001-B1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ahj.2013.11.005","article-title":"Influence of heart failure symptoms and ejection fraction on short- and long-term outcomes for older patients with non-ST-segment elevation myocardial infarction","volume":"167","author":"van Diepen","year":"2014","journal-title":"Am Heart J"},{"key":"2023070503375473000_zuad001-B2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0002-9149(67)90023-9","article-title":"Treatment of myocardial infarction in a coronary care unit. 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