{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:24Z","timestamp":1792785864524,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"crossref","award":["C53325\/A21134"],"award-info":[{"award-number":["C53325\/A21134"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Applied Research Collaboration East Midlands"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Currently, little evidence exists on survival and quality of care in cancer patients presenting with acute heart failure (HF). The aim of the study is to investigate the presentation and outcomes of hospital admission with acute HF in a national cohort of patients with prior cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This retrospective, population-based cohort study identified 221 953 patients admitted to a hospital in England for HF during 2012\u20132018 (12 867 with a breast, prostate, colorectal, or lung cancer diagnosis in the previous 10 years). We examined the impact of cancer on (i) HF presentation and in-hospital mortality, (ii) place of care, (iii) HF medication prescribing, and (iv) post-discharge survival, using propensity score weighting and model-based adjustment. Heart failure presentation was similar between cancer and non-cancer patients. A lower percentage of patients with prior cancer were cared for in a cardiology ward [\u22122.4% age point difference (ppd) (95% CI \u22123.3, \u22121.6)] or were prescribed angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists (ACEi\/ARB) for heart failure with reduced ejection fraction [\u22122.1 ppd (\u22123.3, \u22120.9)] than non-cancer patients. Survival after HF discharge was poor with median survival of 1.6 years in prior cancer and 2.6 years in non-cancer patients. Mortality in prior cancer patients was driven primarily by non-cancer causes (68% of post-discharge deaths).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Survival in prior cancer patients presenting with acute HF was poor, with a significant proportion due to non-cancer causes of death. Despite this, cardiologists were less likely to manage cancer patients with HF. Cancer patients who develop HF were less likely to be prescribed guideline-based HF medications compared with non-cancer patients. This was particularly driven by patients with a poorer cancer prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuad020","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T17:02:17Z","timestamp":1678122137000},"page":"315-327","source":"Crossref","is-referenced-by-count":6,"title":["Acute heart failure presentation, management, and outcomes in cancer patients: a national longitudinal study"],"prefix":"10.1093","volume":"12","author":[{"given":"Briana","family":"Coles","sequence":"first","affiliation":[{"name":"Biostatistics Research Group, Department of Health Sciences, George Davies Centre, University of Leicester , University Road, Leicester, LE1 7RH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-964X","authenticated-orcid":false,"given":"Catherine A","family":"Welch","sequence":"additional","affiliation":[{"name":"Biostatistics Research Group, Department of Health Sciences, George Davies Centre, University of Leicester , University Road, Leicester, LE1 7RH , UK"},{"name":"National Disease Registration Service, NHS Digital , Wellington Place, Leeds, LS1 4AP , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishabh S","family":"Motiwale","sequence":"additional","affiliation":[{"name":"Biostatistics Research Group, Department of Health Sciences, George Davies Centre, University of Leicester , University Road, Leicester, LE1 7RH , UK"},{"name":"School of Medicine, George Davies Centre, University of Leicester, University Road , Leicester, LE1 7RH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Teece","sequence":"additional","affiliation":[{"name":"Biostatistics Research Group, Department of Health Sciences, George Davies Centre, University of Leicester , University Road, Leicester, LE1 7RH , UK"},{"name":"National Disease Registration Service, NHS Digital , Wellington Place, Leeds, LS1 4AP , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3573-2426","authenticated-orcid":false,"given":"Clare","family":"Oliver-Williams","sequence":"additional","affiliation":[{"name":"Biostatistics Research Group, Department of Health Sciences, George Davies Centre, University of Leicester , University Road, Leicester, LE1 7RH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Weston","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Glangwili General Hospital , Dolgwili Road, Carmarthen, SA31 2AF , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"de Belder","sequence":"additional","affiliation":[{"name":"National Institute for Cardiovascular Outcomes Research, Arden & GEM Commissioning Support Unit , St John's House, 30 East Street, Leicester, LE1 6NB , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C","family":"Lambert","sequence":"additional","affiliation":[{"name":"Biostatistics Research Group, Department of Health Sciences, George Davies Centre, University of Leicester , University Road, Leicester, LE1 7RH , UK"},{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , 171 77, Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Biostatistics Research Group, Department of Health Sciences, George Davies Centre, University of Leicester , University Road, Leicester, LE1 7RH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizz","family":"Paley","sequence":"additional","affiliation":[{"name":"National Disease Registration Service, NHS Digital , Wellington Place, Leeds, LS1 4AP , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh T","family":"Kadam","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre, University of Leicester, Leicester General Hospital , Gwendolen Road, Leicester, LE5 4PW , UK"},{"name":"Department of Health Sciences, George Davies Centre, University of Leicester , University Road, Leicester, LE1 7RH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare A","family":"Lawson","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre, University of Leicester, Leicester General Hospital , Gwendolen Road, Leicester, LE5 4PW , UK"},{"name":"Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital , Groby Road, Leicester, LE3 9QP , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Deanfield","sequence":"additional","affiliation":[{"name":"National Institute for Cardiovascular Outcomes Research, Arden & GEM Commissioning Support Unit , St John's House, 30 East Street, Leicester, LE1 6NB , UK"},{"name":"Institute of Cardiovascular Science, University College London , 62 Huntley Street, London, WC1E 6DD , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Peake","sequence":"additional","affiliation":[{"name":"National Disease Registration Service, NHS Digital , Wellington Place, Leeds, LS1 4AP , UK"},{"name":"Department of Respiratory Medicine, University of Leicester, Glenfield Hospital , Groby Road, Leicester, LE3 9QP , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"McDonagh","sequence":"additional","affiliation":[{"name":"King's College Hospital, Denmark Hill , London, SE5 9RS , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Sweeting","sequence":"additional","affiliation":[{"name":"Biostatistics Research Group, Department of Health Sciences, George Davies Centre, University of Leicester , University Road, Leicester, LE1 7RH , UK"},{"name":"Statistical Innovation, AstraZeneca, City House , Hills Road, Cambridge CB2 1RY , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-9884","authenticated-orcid":false,"given":"David","family":"Adlam","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital , Groby Road, Leicester, LE3 9QP , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"VICORI collaborative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Darby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Gale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jem","family":"Rashbass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Reulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair Ring Adam","family":"Timmis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally Vernon Jennifer","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Charlton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akosua","family":"Donkor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Fazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Gunesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Khushnood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Goodwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ludman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"McDonagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Murgatroyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Shand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Vernon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Forman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,8]]},"container-title":["European Heart Journal: Acute Cardiovascular Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjacc\/advance-article-pdf\/doi\/10.1093\/ehjacc\/zuad020\/50059683\/zuad020.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/12\/5\/315\/50189703\/zuad020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjacc\/article-pdf\/12\/5\/315\/50189703\/zuad020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T20:30:06Z","timestamp":1683145806000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjacc\/article\/12\/5\/315\/7072737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3,8]]},"published-print":{"date-parts":[[2023,5,4]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjacc\/zuad020","relation":{},"ISSN":["2048-8726","2048-8734"],"issn-type":[{"value":"2048-8726","type":"print"},{"value":"2048-8734","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,4]]},"published":{"date-parts":[[2023,3,8]]}}}