{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:35:51Z","timestamp":1785159351583,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>High- (HR) and intermediate-high risk (IHR) pulmonary embolisms (PEs) are related to high early mortality and long-term sequelae. We aimed to describe clinical outcomes and adverse events in IHR and HR pulmonary embolism (PE) treated with catheter-directed mechanical thrombectomy (CDMT) in a real-world population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Results<\/jats:title>\n                  <jats:p>This study is a multicenter, prospective registry enrolling 110 PE patients treated with CDMT between 2019 and 2022. The CDMT was performed using the 8F Indigo (Penumbra, Alameda, CA, USA) system bilaterally in pulmonary arteries (PAs). The primary safety endpoints included device or PE-related death during the 48-h after CDMT, procedure-related major bleeding, or other major adverse events. Secondary safety outcomes were all-cause mortality during hospitalization or the follow-up. The primary efficacy outcomes were the reduction of PA pressures and change in the right-to-left ventricular (RV\/L) ratio assessed in the imaging 24\u201348 h after the CDMT.<\/jats:p>\n                  <jats:p>71.8% of patients had IHR PE and 28.2% HR PE. 11.8% of patients had a failure and 34.5% had contraindications to thrombolysis, and 2.7% had polytrauma. There was 0.9% intraprocedural death related to RV failure and 5.5% deaths within the first 48 h. CDMT was complicated by major bleeding in 1.8%, pulmonary artery injury in 1.8%, and ischaemic stroke in 0.9%. Immediate haemodynamic improvements included a 10.4 \u00b1 7.8 mmHg (19.7%) drop in systolic PAP (P &amp;lt; 0.0001), a 6.1 \u00b1 4.2 mmHg (18.8%) drop in mean PAP, and 0.48 \u00b1 0.4 (36%) drop in RV\/LV ratio (P &amp;lt; 0.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These observational findings suggest that CDMT may improve hemodynamics with an acceptable safety profile in patients with IHR and HR PE.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuad066","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T20:02:28Z","timestamp":1686859348000},"page":"584-593","source":"Crossref","is-referenced-by-count":15,"title":["Catheter-directed mechanical aspiration thrombectomy in a real-world pulmonary embolism population: a multicenter registry"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1143-2485","authenticated-orcid":false,"given":"Sylwia","family":"S\u0142awek-Szmyt","sequence":"first","affiliation":[{"name":"Department of Cardiology, Poznan University of Medical Sciences , D\u0142uga 1\/2 Street, 61-848 Poznan , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"St\u0119pniewski","sequence":"additional","affiliation":[{"name":"Pulmonary Circulation Centre, Department of Cardiac and Vascular Disease, Jagiellonian University Medical College, John Paul II Hospital in Krakow, Pr\u0105dnicka 80 Street, 31-202 Krakow, Poland"},{"name":"Department of Medical Education, Jagiellonian University Medical College , Medyczna 7 Street, 30-688 Krakow , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Kurzyna","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Circulation, Thromboembolic Diseases and Cardiology European Health Centre Otwock, Medical Centre for Postgraduate Education , Borowa 14\/18 Street, 05-400 Otwock , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiktor","family":"Kuliczkowski","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Wroclaw Medical University , Borowska 213 Street, 50-556 Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanis\u0142aw","family":"Jankiewicz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Poznan University of Medical Sciences , D\u0142uga 1\/2 Street, 61-848 Poznan , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Kope\u0107","sequence":"additional","affiliation":[{"name":"Pulmonary Circulation Centre, Department of Cardiac and Vascular Disease, Jagiellonian University Medical College, John Paul II Hospital in Krakow, Pr\u0105dnicka 80 Street, 31-202 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szymon","family":"Darocha","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Circulation, Thromboembolic Diseases and Cardiology European Health Centre Otwock, Medical Centre for Postgraduate Education , Borowa 14\/18 Street, 05-400 Otwock , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Mroczek","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Wroclaw Medical University , Borowska 213 Street, 50-556 Wroclaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkadiusz","family":"Pietrasik","sequence":"additional","affiliation":[{"name":"Department and Faculty of Cardiology, Medical University of Warsaw , Banacha 1A Street, 02-097 Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Grygier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, 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