{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T20:32:38Z","timestamp":1769977958914,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003100","name":"F\u00e9d\u00e9ration Fran\u00e7aise de Cardiologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003100","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Maquet SAS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Characteristics, management, and outcomes of patients with active cancer admitted for cardiogenic shock remain largely unknown. This study aimed to address this issue and identify the determinants of 30-day and 1-year mortality in a large cardiogenic shock cohort of all aetiologies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>FRENSHOCK is a prospective multicenter observational registry conducted in French critical care units between April and October 2016. \u2018Active cancer\u2019 was defined as a malignancy diagnosed within the previous weeks with planned or ongoing anticancer therapy. Among the 772 enrolled patients (mean age 65.7 \u00b1 14.9 years; 71.5% male), 51 (6.6%) had active cancer. Among them, the main cancer types were solid cancers (60.8%), and hematological malignancies (27.5%). Solid cancers were mainly urogenital (21.6%), gastrointestinal (15.7%), and lung cancer (9.8%). Medical history, clinical presentation, and baseline echocardiography were almost the same between groups. In-hospital management significantly differed: patients with cancers received more catecholamines or inotropes (norepinephrine 72% vs. 52%, P = 0.005 and norepinephrine-dobutamine combination 64.7% vs. 44.5%, P = 0.005), but had less mechanical circulatory support (5.9% vs. 19.5%, P = 0.016). They presented a similar 30-day mortality rate (29% vs. 26%) but a significantly higher mortality at 1-year (70.6% vs. 45.2%, P &amp;lt; 0.001). In multivariable analysis, active cancer was not associated with 30-day mortality but was significantly associated with 1-year mortality in 30-day survivors [HR 3.61 (1.29\u201310.11), P = 0.015].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Active cancer patients accounted for almost 7% of all cases of cardiogenic shock. Early mortality was the same regardless of active cancer or not, whereas long-term mortality was significantly increased in patients with active cancer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuad072","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T16:26:51Z","timestamp":1688660811000},"page":"682-692","source":"Crossref","is-referenced-by-count":7,"title":["Characteristics, management, and outcomes of active cancer patients with cardiogenic shock"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4670-1596","authenticated-orcid":false,"given":"Hamid","family":"Merdji","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Strasbourg (UNISTRA), Strasbourg university hospital, Nouvel H\u00f4pital Civil, Medical intensive care unit , Strasbourg , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3293-4903","authenticated-orcid":false,"given":"Justine","family":"Gantzer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Strasbourg-Europe Cancer Institute (ICANS) , Strasbourg , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Bonello","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9 , F-13385 Marseille , France"},{"name":"Intensive Care Unit, Department of Cardiology, Assistance Publique-H\u00f4pitaux de Marseille, H\u00f4pital Nord , F-13385 Marseille , France"},{"name":"Mediterranean Association for Research and Studies in Cardiology (MARS Cardio) , Marseille , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Lamblin","sequence":"additional","affiliation":[{"name":"Urgences et Soins Intensifs de Cardiologie, CHU Lille, University of Lille, Inserm U1167 , F-59000, Lille , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5288-9687","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Roubille","sequence":"additional","affiliation":[{"name":"Cardiology Department, PhyMedExp, Universit\u00e9 de Montpellier, INSERM, CNRS, INI-CRT, CHU de Montpellier , Montpellier , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Levy","sequence":"additional","affiliation":[{"name":"CHRU Nancy, R\u00e9animation M\u00e9dicale Brabois , Vandoeuvre-les Nancy , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien","family":"Champion","sequence":"additional","affiliation":[{"name":"Clinique de Parly 2, Ramsay G\u00e9n\u00e9rale de Sant\u00e9 , 21 rue Moxouris, 78150 Le Chesnay , 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