{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:11:32Z","timestamp":1790698292494,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012680","name":"University Medical Center Hamburg-Eppendorf","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2019_A142"],"award-info":[{"award-number":["2019_A142"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Shock of any cause leads to end-organ damage due to ischaemia, especially in perfusion-sensitive organs such as the liver. In septic shock, hypoxic hepatitis (S-HH) is defined as the 20-fold increase of the upper normal limit of aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) and is associated with a mortality of up to 60%. However, as pathophysiology, dynamics, and treatment differ between septic and cardiogenic shock (CS), the S-HH definition may not be suitable for CS. Therefore, we aim to evaluate if the S-HH definition is applicable in CS patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This analysis was based on a registry of all-comer CS patients treated between 2009 and 2019 at a tertiary care centre with exclusion of minors and patients without all necessary ASAT and ALAT values. N = 698. During in-hospital follow-up, 386 (55.3%) patients died. The S-HH was not significantly associated with in-hospital mortality in CS patients. To define HH among patients with CS (C-HH), optimal cut-off values were found to be \u22651.34-fold increase for ASAT and \u22651.51-fold increase for ALAT in serial measurements. The incidence of C-HH was 254\/698 patients (36%) and C-HH showed a strong association with in-hospital mortality (odds ratio 2.36, 95% confidence interval: 1.61, 3.49).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The C-HH is a frequent and relevant comorbidity in patients with CS, although its definition varies from the established definition of HH in patients with septic shock. As C-HH contributed to excess mortality risk, these findings emphasize the need for further investigation of therapies reducing the occurrence of C-HH and also improving the associated outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuad076","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T16:30:06Z","timestamp":1688661006000},"page":"663-670","source":"Crossref","is-referenced-by-count":15,"title":["Incidence of hypoxic hepatitis in patients with cardiogenic shock and association with mortality"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4315-2533","authenticated-orcid":false,"given":"Benedikt N","family":"Beer","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Medical Center Hamburg-Eppendorf , Martinistr. 52, Hamburg 20246 , Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg\/L\u00fcbeck\/Kiel , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Besch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Hamburg-Eppendorf , Martinistr. 52, Hamburg 20246 , Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg\/L\u00fcbeck\/Kiel , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-8766","authenticated-orcid":false,"given":"Jessica","family":"Weimann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Hamburg-Eppendorf , Martinistr. 52, Hamburg 20246 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore","family":"Surendra","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Hamburg-Eppendorf , Martinistr. 52, Hamburg 20246 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Roedl","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf , Martinistr. 52, Hamburg 20246 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn","family":"Grensemann","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf , Martinistr. 52, Hamburg 20246 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Sundermeyer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Hamburg-Eppendorf , Martinistr. 52, Hamburg 20246 , Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg\/L\u00fcbeck\/Kiel , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Dettling","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Hamburg-Eppendorf , Martinistr. 52, Hamburg 20246 , Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg\/L\u00fcbeck\/Kiel , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8391-3988","authenticated-orcid":false,"given":"Stefan","family":"Kluge","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf , Martinistr. 52, Hamburg 20246 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1881-0197","authenticated-orcid":false,"given":"Paulus","family":"Kirchhof","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Hamburg-Eppendorf , Martinistr. 52, Hamburg 20246 , Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg\/L\u00fcbeck\/Kiel , Germany"},{"name":"Institute of Cardiovascular Sciences, University of Birmingham , Edgbaston, Birmingham B15 2TT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Hamburg-Eppendorf , Martinistr. 52, Hamburg 20246 , Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg\/L\u00fcbeck\/Kiel , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-6793","authenticated-orcid":false,"given":"Clemens","family":"Scherer","sequence":"additional","affiliation":[{"name":"Department of Medicine I, University Hospital, LMU Munich , Marchioninistr. 15, Munich 81377 , 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