{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:06:08Z","timestamp":1793016368208,"version":"4.5.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008375","name":"University Basel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016015","name":"University Hospital Basel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004362","name":"Swiss Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016545","name":"Roche Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Astra Zeneca"},{"name":"Forschungsfond Kantonsspital Aarau"},{"DOI":"10.13039\/100007478","name":"Cardiovascular Research Foundation Basel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/23731\u20136"],"award-info":[{"award-number":["2015\/23731\u20136"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Perioperative myocardial infarction\/injury (PMI) is a surprisingly common yet difficult-to-predict cardiac complication in patients undergoing noncardiac surgery. We aimed to assess the incremental value of preoperative cardiac troponin (cTn) concentration in the prediction of PMI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Among prospectively recruited patients at high cardiovascular risk (age \u226565 years or \u226545 years with preexisting cardiovascular disease), PMI was defined as an absolute increase in high-sensitivity cTnT (hs-cTnT) concentration of \u226514 ng\/L (the 99th percentile) above the preoperative concentration. Perioperative myocardial infarction\/injury was centrally adjudicated by two independent cardiologists using serial measurements of hs-cTnT. Using logistic regression, three models were derived: Model 1 including patient- and procedure-related information, Model 2 adding routinely available laboratory values, and Model 3 further adding preoperative hs-cTnT concentration. Models were also compared vs. preoperative hs-cTnT alone. The findings were validated in two independent cohorts. Among 6944 patients, PMI occurred in 1058 patients (15.2%). The predictive accuracy as quantified by the area under the receiver operating characteristic curve was 0.73 [95% confidence interval (CI) 0.71\u20130.74] for Model 1, 0.75 (95% CI 0.74\u20130.77) for Model 2, 0.79 (95% CI 0.77\u20130.80) for Model 3, and 0.74 for hs-cTnT alone. Model 3 included 10 preoperative variables: age, body mass index, known coronary artery disease, metabolic equivalent &amp;gt;4, risk of surgery, emergency surgery, planned duration of surgery, haemoglobin, platelet count, and hs-cTnT. These findings were confirmed in both independent validation cohorts (n = 722 and n = 966).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Preoperative cTn adds incremental value above patient- and procedure-related variables as well as routine laboratory variables in the prediction of PMI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuad090","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T04:03:10Z","timestamp":1691121790000},"page":"729-739","source":"Crossref","is-referenced-by-count":10,"title":["Prediction of perioperative myocardial infarction\/injury in high-risk patients after noncardiac surgery"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3294-305X","authenticated-orcid":false,"given":"Rebecca","family":"Meister","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel , Spitalstrasse 2, CH-4031 Basel, Basel-Stadt , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3206-6349","authenticated-orcid":false,"given":"Christian","family":"Puelacher","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel , Spitalstrasse 2, CH-4031 Basel, Basel-Stadt , Switzerland"},{"name":"Department of Internal Medicine, University Hospital Basel, University of Basel , Spitalstrasse 21, 4031 Basel, Basel-Stadt , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Glarner","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel , Spitalstrasse 2, CH-4031 Basel, Basel-Stadt , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Menosi","family":"Gualandro","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel , Spitalstrasse 2, CH-4031 Basel, Basel-Stadt , Switzerland"},{"name":"Interdisciplinary Medicine in Cardiology Unit, Cardiology Department, Heart Institute (InCor), University of Sao Paulo Medical School , Av. Dr. En\u00e9as Carvalho de Aguiar, 44, Cerqueira C\u00e9sar, 05403-900 S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik A","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Link\u00f6ping University Hospital , SE-581 83 Link\u00f6ping , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Pargger","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel , Spitalstrasse 2, CH-4031 Basel, Basel-Stadt , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Hur\u00e9","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel , Spitalstrasse 2, CH-4031 Basel, Basel-Stadt , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgiana","family":"Virant","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel , Spitalstrasse 2, CH-4031 Basel, Basel-Stadt , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bolliger","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, University Hospital Basel, University of Basel , Spitalstrasse 21, 4031 Basel, Basel-Stadt , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Lampart","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, University Hospital Basel, University of Basel , Spitalstrasse 21, 4031 Basel, Basel-Stadt , 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Buse","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, University Hospital Dusseldorf , Moorenstr. 5 40225 D\u00fcsseldorf, NRW , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0464-3460","authenticated-orcid":false,"given":"Christoph","family":"Kindler","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Cantonal Hospital Aarau , Tellstrasse 25, 5001 Aarau, Aargau , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"G\u00fcrke","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Hospital Basel, University Basel , Spitalstrasse 21, 4031 Basel, Basel-Stadt , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edin","family":"Mujagic","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Hospital Basel, University Basel , Spitalstrasse 21, 4031 Basel, Basel-Stadt , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schaeren","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, University Hospital Basel, University Basel , Spitalstrasse 21, 4031 Basel, Basel-Stadt , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Clauss","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Center of Musculoskeletal Infections, University Hospital Basel, University Basel , Spitalstrasse 21, 4031 Basel, Basel-Stadt , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Lardinois","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospital Basel, University of Basel , Spitalstrasse 21, 4031 Basel, Basel-Stadt , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Hammerer-Lercher","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Cantonal Hospital Aarau , Tellstrasse 25, 5001 Aarau, Aargau , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Link\u00f6ping University Hospital , SE-581 83 Link\u00f6ping , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-6405","authenticated-orcid":false,"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel , Spitalstrasse 2, CH-4031 Basel, Basel-Stadt , 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