{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:17:16Z","timestamp":1785831436507,"version":"3.56.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF17OC0028706 and NNF22OC0079649"],"award-info":[{"award-number":["NNF17OC0028706 and NNF22OC0079649"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20SA0067242"],"award-info":[{"award-number":["NNF20SA0067242"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Danish Cardiovascular Academy"},{"DOI":"10.13039\/100007405","name":"Danish Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Anxiety, depression, and post-traumatic stress disorder (PTSD) among out-of-hospital cardiac arrest (OHCA) survivors may impact long-term recovery. Coping and perception of symptoms may vary between sexes. The aim was to explore sex differences in psychological consequences following OHCA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This was a prospective observational study of OHCA survivors who attended a structured 3-month follow-up. Symptoms of anxiety\/depression were measured using the Hospital Anxiety and Depression Scale, range 0\u201321, with a cut-off score of \u22658 for significant symptoms; PTSD was measured with the PTSD Checklist for DSM-5 (PCL-5), range 0\u201380. A score of \u226533 indicated PTSD symptoms. Cognitive function was assessed by the Montreal Cognitive Assessment. From 2016 to 2021, 381 consecutive comatose OHCA survivors were invited. Of these, 288 patients (76%) participated in the follow-up visit [53 (18%) females out of 80 survivors and 235 (82%) males out of 300 alive at follow-up (78%)]. Significant symptoms of anxiety were present in 47 (20%) males and 19 (36%) females (P = 0.01). Significant symptoms of PTSD were present in 30% of males and 55% of females (P = 0.01). Adjusting for pre-specified covariates using multivariable logistic regression, female sex was significantly associated with anxiety [odds ratio (OR): 2.18, confidence interval (CI): 1.09\u20134.38, P = 0.03]. This difference was especially pronounced among young females (below median age, ORadjusted: 3.31, CI: 1.32\u20138.29, P = 0.01) compared with young males. No significant sex difference was observed for depression or cognitive function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Symptoms of anxiety and PTSD are frequent in OHCA survivors, and female survivors report significantly more symptoms of anxiety and PTSD compared with males. In particular, young females were significantly more symptomatic than young males.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuad093","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T08:18:20Z","timestamp":1691482700000},"page":"765-773","source":"Crossref","is-referenced-by-count":10,"title":["Sex differences in symptoms of anxiety, depression, post-traumatic stress disorder, and cognitive function among survivors of out-of-hospital cardiac arrest"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5511-4668","authenticated-orcid":false,"given":"Johannes","family":"Grand","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Blegdamsvej 9, 2100 Copenhagen , Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital Amager-Hvidovre , Ketteg\u00e5rd Alle 30, 2650 Hvidovre , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie","family":"Fuglsbjerg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2702-0231","authenticated-orcid":false,"given":"Britt","family":"Borregaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital , J. B. Winsl\u00f8ws Vej 4, 5000 Odense , Denmark"},{"name":"Department of Cardiac, Thoracic and Vascular Surgery , Odense University Hospital, J. B. Winsl\u00f8ws Vej 4, 5000 Odense , Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark , Campusvej 55, 5230 Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9461-1416","authenticated-orcid":false,"given":"Mette Kirstine","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid Rolin","family":"Kragh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte","family":"Bekker-Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital , J. B. 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Winsl\u00f8ws Vej 4, 5000 Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Glud","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Blegdamsvej 9, 2100 Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1199-0981","authenticated-orcid":false,"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Blegdamsvej 9, 2100 Copenhagen , Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen , Blegdamsvej 3B, 2200 K\u00f8benhavn , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"Kikkenborg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet , Blegdamsvej 9, 2100 Copenhagen 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