{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:55:14Z","timestamp":1791996914892,"version":"4.4.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Invasive haemodynamic assessment with a pulmonary artery catheter is often used to guide the management of patients with cardiogenic shock (CS) and may provide important prognostic information. We aimed to assess prognostic associations and relationships to end-organ dysfunction of presenting haemodynamic parameters in CS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The Critical Care Cardiology Trials Network is an investigator-initiated multicenter registry of cardiac intensive care units (CICUs) in North America coordinated by the TIMI Study Group. Patients with CS (2018\u20132022) who underwent invasive haemodynamic assessment within 24 h of CICU admission were included. Associations of haemodynamic parameters with in-hospital mortality were assessed using logistic regression, and associations with presenting serum lactate were assessed using least squares means regression. Sensitivity analyses were performed excluding patients on temporary mechanical circulatory support and adjusted for vasoactive-inotropic score. Among the 3603 admissions with CS, 1473 had haemodynamic data collected within 24 h of CICU admission. The median cardiac index was 1.9 (25th\u201375th percentile, 1.6\u20132.4) L\/min\/m2 and mean arterial pressure (MAP) was 74 (66\u201386) mmHg. Parameters associated with mortality included low MAP, low systolic blood pressure, low systemic vascular resistance, elevated right atrial pressure (RAP), elevated RAP\/pulmonary capillary wedge pressure ratio, and low pulmonary artery pulsatility index. These associations were generally consistent when controlling for the intensity of background pharmacologic and mechanical haemodynamic support. These parameters were also associated with higher presenting serum lactate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a contemporary CS population, presenting haemodynamic parameters reflecting decreased systemic arterial tone and right ventricular dysfunction are associated with adverse outcomes and systemic hypoperfusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuad095","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T18:02:49Z","timestamp":1692208969000},"page":"651-660","source":"Crossref","is-referenced-by-count":28,"title":["Prognostic significance of haemodynamic parameters in patients with cardiogenic shock"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-5492","authenticated-orcid":false,"given":"David D","family":"Berg","sequence":"first","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 60 Fenwood Road, Suite 7022, Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurleen","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin A","family":"Bohula","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 60 Fenwood Road, Suite 7022, Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian M","family":"Baird-Zars","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 60 Fenwood Road, Suite 7022, Boston, MA 02115 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos L","family":"Alviar","sequence":"additional","affiliation":[{"name":"Leon H Charney Division of Cardiology, Bellevue Hospital Center, New York University School of Medicine , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher F","family":"Barnett","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of California San Francisco , San Francisco, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W","family":"Barsness","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , Rochester, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A","family":"Burke","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Lehigh Valley Heart Network , Allentown, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunit-Preet","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Vincent Heart Center , Indianapolis, IN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meshe","family":"Chonde","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute , Cedars-Sinai Medical Center, Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A","family":"Cooper","sequence":"additional","affiliation":[{"name":"Westchester Medical Center, New York Medical College , Valhalla, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori B","family":"Daniels","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego , La Jolla, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W","family":"Dodson","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Intermountain Medical Center , Murray, UT , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A","family":"Gerber","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Stanford University School of Medicine , Stanford, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahab","family":"Ghafghazi","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine, University of Louisville , Louisville, KY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh K","family":"Gidwani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Zena and Michael A. 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