{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:56:49Z","timestamp":1793555809662,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011949","name":"Abbott Vascular and Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific and Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Patients with premature coronary artery disease (CAD) have a higher incidence of myocardial infarction (MI) than patients with non-premature CAD. The aim of the present study is to asess differences in clinical outcome after a first acute MI, percutaneously treated with new-generation drug-eluting stents between patients with premature and non-premature CAD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We pooled and analysed the characteristics and clinical outcome of all patients with a first MI (and no previous coronary revascularization) at time of enrolment, in four large-scale drug-eluting stent trials. Coronary artery disease was classified premature in men aged &amp;lt;50 and women &amp;lt;55 years. Myocardial infarction patients with premature and non-premature CAD were compared. The main endpoint was major adverse cardiac events (MACE): all-cause mortality, any MI, emergent coronary artery bypass surgery, or clinically indicated target lesion revascularization. Of 3323 patients with a first MI, 582 (17.5%) had premature CAD. These patients had lower risk profiles and underwent less complex interventional procedures than patients with non-premature CAD. At 30-day follow-up, the rates of MACE [hazard ratio (HR): 0.22, 95% confidence interval (CI): 0.07\u20130.71; P = 0.005), MI (HR: 0.22, 95% CI: 0.05\u20130.89; P = 0.020), and target vessel failure (HR: 0.30, 95% CI: 0.11\u20130.82; P = 0.012) were lower in patients with premature CAD. At 1 year, premature CAD was independently associated with lower rates of MACE (adjusted HR: 0.50, 95% CI: 0.26\u20130.96; P = 0.037) and all-cause mortality (adjusted HR: 0.24, 95% CI: 0.06\u20130.98; P = 0.046). At 2 years, premature CAD was independently associated with lower mortality (adjusted HR: 0.16, 95% CI: 0.05\u20130.50; P = 0.002).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>First MI patients with premature CAD, treated with contemporary stents, showed lower rates of MACE and all-cause mortality than patients with non-premature CAD, which is most likely related to differences in cardiovascular risk profile.<\/jats:p>\n                  <jats:p>TWENTE trials: TWENTE I, clinicaltrials.gov: NCT01066650), DUTCH PEERS (TWENTE II, NCT01331707), BIO-RESORT (TWENTE III, NCT01674803), and BIONYX (TWENTE IV, NCT02508714)<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuad098","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T20:46:31Z","timestamp":1692737191000},"page":"774-781","source":"Crossref","is-referenced-by-count":4,"title":["First myocardial infarction in patients with premature coronary artery disease: insights into patient characteristics and outcome after treatment with contemporary stents"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-8742","authenticated-orcid":false,"given":"Tineke H","family":"Pinxterhuis","sequence":"first","affiliation":[{"name":"Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente , Koningsplein 1, Enschede 7512 KZ , The Netherlands"},{"name":"Department of Health Technology and Services Research, Faculty BMS, Technical Medical Centre, University of Twente , Hallenweg 5, 7522 NH Enschede , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline H","family":"Ploumen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente , Koningsplein 1, Enschede 7512 KZ , The Netherlands"},{"name":"Department of Health Technology and Services Research, Faculty BMS, Technical Medical Centre, University of Twente , Hallenweg 5, 7522 NH Enschede , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine J M","family":"Doggen","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Services Research, Faculty BMS, Technical Medical Centre, University of Twente , Hallenweg 5, 7522 NH Enschede , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente , Koningsplein 1, Enschede 7512 KZ , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl E","family":"Schotborgh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Haga Hospital , The Hague , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutger L","family":"Anthonio","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Treant Zorggroep, Scheper Hospital , Emmen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Roguin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hillel Yaffe Medical Center, Hadera and B. Rappaport-Faculty of Medicine, Israel Institute of Technology , Haifa , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W","family":"Danse","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rijnstate Hospital , Arnhem , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Benit","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jessa Hospital , Hasselt , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Aminian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centre Hospitalier Universitaire de Charleroi , Charleroi , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard C M","family":"Linssen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuisgroep Twente , Almelo and Hengelo , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5128-2832","authenticated-orcid":false,"given":"Clemens","family":"von Birgelen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente , Koningsplein 1, Enschede 7512 KZ , The Netherlands"},{"name":"Department of Health Technology and Services Research, Faculty BMS, Technical Medical Centre, University of Twente , Hallenweg 5, 7522 NH Enschede , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"2023111619512730900_zuad098-B1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.mayocp.2019.05.001","article-title":"Acute myocardial infarction in young individuals","volume":"95","author":"Gulati","year":"2020","journal-title":"Mayo Clin 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