{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:51:38Z","timestamp":1781801498348,"version":"3.54.5"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Hypoperfusion portends adverse outcomes in acute heart failure (AHF). The gradient between end-organ inflow and outflow pressures may more closely reflect hypoperfusion than mean arterial pressure (MAP) alone. The aim of this study was to investigate organ perfusion pressure (OPP), calculated as MAP minus central venous pressure (CVP), as a prognostic marker in AHF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The Sodium NItroPrusside Treatment in Acute Heart Failure (SNIP)-AHF study was a multicentre retrospective cohort study of 200 consecutive patients hospitalized for AHF treated with sodium nitroprusside. Only patients with both MAP and invasive CVP data available from the SNIP-AHF cohort were included in this analysis. The primary endpoint was to assess OPP as a predictor of worsening heart failure (WHF), defined as the worsening of signs and symptoms of heart failure leading to intensification of therapy at 48\u2005h. One hundred and forty-six patients fulfilling the inclusion criteria were included [mean age: 61.1 \u00b1 13.5 years, 32 (21.9%) females; mean body mass index: 26.2 \u00b1 11.7\u2005kg\/m2; mean left ventricular ejection fraction: 23.8%\u00b111.4%, mean MAP: 80.2 \u00b1 13.2\u2005mmHg, and mean CVP: 14.0 \u00b1 6.1\u2005mmHg]. WHF occurred in 14 (9.6%) patients. At multivariable models including hemodynamic variables (OPP, shock index, and CVP), OPP at admission was the best predictor of WHF at 48\u2005h [OR 0.91 (95% confidence interval 0.86\u20130.96), P-value = 0.001] with an optimal cut-off value of 67.5\u2005mmHg (specificity 47.3%, sensitivity 100%, and AUC 0.784 \u00b1 0.054). In multivariable models, including univariable significant parameters available at first bedside assessment, namely New York Heart Association functional class, OPP, shock index, CVP, and left ventricular end-diastolic diameter, OPP consistently and significantly predicted WHF at 48\u2005h.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In this retrospective analysis on patients hospitalized for AHF treated with sodium nitroprusside, on-admission OPP significantly predicted WHF at 48\u2005h with high sensitivity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuad133","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T19:41:42Z","timestamp":1698349302000},"page":"215-224","source":"Crossref","is-referenced-by-count":5,"title":["Organ perfusion pressure at admission and clinical outcomes in patients hospitalized for acute heart 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-0891","authenticated-orcid":false,"given":"Filippo","family":"Angelini","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department, \u2018Citta della Salute e della Scienza\u2019 Hospital , Turin , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-6844","authenticated-orcid":false,"given":"Guglielmo","family":"Gallone","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department, \u2018Citta della Salute e della Scienza\u2019 Hospital , Turin , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Garatti","sequence":"additional","affiliation":[{"name":"Department of Cardiology De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Sacco","sequence":"additional","affiliation":[{"name":"Department of Cardiology De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Raineri","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department, \u2018Citta della Salute e della Scienza\u2019 Hospital , Turin , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pidello","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department, \u2018Citta della Salute e della Scienza\u2019 Hospital , Turin , 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