{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:34:17Z","timestamp":1780626857576,"version":"3.54.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Heart Research Foundation German Cardiac Society","award":["NCT01927549"],"award-info":[{"award-number":["NCT01927549"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We analysed consecutive patients with acute myocardial infarction complicated by cardiogenic shock (CS) who were enrolled into the CULPRIT-SHOCK randomized controlled trial (RCT) and those with exclusion criteria who were included into the accompanying registry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In total, 1075 patients with infarct-related CS were screened for CULPRIT-SHOCK in 83 specialized centres in Europe; 369 of them had exclusion criteria for the RCT and were enrolled into the registry. Patients were followed over 1 year. The mean age was 68 years and 260 (25%) were women. 13.5%, 30.9%, and 55.6% had one-vessel, two-vessel, and three-vessel coronary artery disease (CAD), respectively. Significant left main (LM) coronary artery stenosis was present in 8.0%. 54.2% of the patients had cardiac arrest before admission. Thrombolysis in myocardial infarction (TIMI) 3 patency of the infarct vessel after percutaneous coronary intervention was achieved in 83.6% of all patients. Mechanical circulatory support was applied in one-third of patients. Total mortality after 30 days and 1 year was 47.6% and 52.9%. Mortality after 1 year was highest in patients with LM coronary artery stenosis (63.5%), followed by three-vessel (56.6%), two-vessel (49.8%), and one-vessel CAD (38.6%), respectively. Mechanical complications were rare (21\/1008; 2.1%) but associated with a high mortality of 66.7% after 1 year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In specialized centres in Europe, short- and long-term mortality of patients with infarct-related CS treated with an invasive strategy is still high and mainly depends on the extent of CAD. Therefore, there is still a need for improvement of care to improve the prognosis of infarct-related CS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuae020","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T21:25:24Z","timestamp":1707773124000},"page":"335-346","source":"Crossref","is-referenced-by-count":5,"title":["Current spectrum and outcomes of infarct-related cardiogenic shock: insights from the CULPRIT-SHOCK registry and randomized controlled trial"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-283X","authenticated-orcid":false,"given":"Uwe","family":"Zeymer","sequence":"first","affiliation":[{"name":"Department of Cardiology, Klinikum der Stadt Ludwigshafen am Rhein , Bremserstra\u00dfe 79, 67063 Ludwigshafen , Germany"},{"name":"Stiftung Institut f\u00fcr Herzinfarktforschung , Bremserstra\u00dfe 79, 67063 Ludwigshafen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-9918","authenticated-orcid":false,"given":"Tobias","family":"Heer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, M\u00fcnchen Klinik Neuperlach, Academic Teaching Hospital, LMU University of Munich , Oskar-Maria-Graf-Ring 51, 81737 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7742-4408","authenticated-orcid":false,"given":"Taoufik","family":"Ouarrak","sequence":"additional","affiliation":[{"name":"Stiftung Institut f\u00fcr Herzinfarktforschung , Bremserstra\u00dfe 79, 67063 Ludwigshafen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-7115","authenticated-orcid":false,"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e4tsmedizin Mannheim , Mannheim , 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Sigmund Freud University , Vienna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2653-6762","authenticated-orcid":false,"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Bern, Inselspital , Bern , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-547X","authenticated-orcid":false,"given":"Stefano","family":"Savonitto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Manzoni Hospital , Lecco , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-5702","authenticated-orcid":false,"given":"Christiaan","family":"Vrints","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universitair Ziekenhuis Antwerp , Antwerp , 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