{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:27:46Z","timestamp":1793125666862,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A recently published trial has shown no differences in outcomes between patients with new-onset supraventricular arrhythmia (SVA) in septic shock treated with either propafenone or amiodarone. However, these outcome data have not been evaluated in relation to the presence or absence of a dilated left atrium (LA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with SVA and a left ventricular ejection fraction \u226535% were randomized to receive intravenous propafenone (70mg bolus followed by 400-840mg\/24h) or amiodarone (300mg bolus followed by 600-1800mg\/24h). They were divided into groups based on whether their end-systolic left atrial volume (LAVI) was \u226540 ml\/m\u00b2. The subgroup outcomes assessed were survival at ICU discharge, 1-month, 3-months, 6-months, and 12-months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Propafenone cardioverted earlier (p=0.009) and with fewer recurrences (p=0.001) in the patients without LA enlargement (n=133). Patients with LAVI\u02c240ml\/m2 demonstrated a mortality benefit of propafenone over the follow up of 1-year (Cox regression, HR 0.6 (95% CI 0.4; 0.9), p=0.014). Patients with dilated LA (n=37) achieved rhythm control earlier in amiodarone (p=0.05) with similar rates of recurrences (p=0.5) compared to propafenone. The outcomes for patients with LAVI\u226540 ml\/m2 were less favourable with propafenone compared to amiodarone at 1-month (HR 3.6 (95% CI 1.03; 12.5), p=0.045) however, it did not reach statistical significance at 1 year (HR 1.9 (95% CI 0.8; 4.4), p=0.138).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with non-dilated LA who achieved rhythm control with propafenone in the setting of septic shock had better short-term and long-term outcomes than those treated with amiodarone, which seemed to be more effective in patients with LAVI\u226540 ml\/m\u00b2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov Identifier: NCT03029169, registered on 24th of January 2017<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuae023","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T16:26:08Z","timestamp":1708014368000},"source":"Crossref","is-referenced-by-count":9,"title":["The outcomes of patients with septic shock treated with propafenone compared to amiodarone for supraventricular arrhythmias are related to end-systolic left atrial volume"],"prefix":"10.1093","author":[{"given":"P","family":"Waldauf","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital in Prague , Czechia, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Porizka","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 1st Faculty of Medicine, Charles University and General University Hospital in Prague"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Horejsek","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 1st Faculty of Medicine, Charles University and General University Hospital in Prague"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Otahal","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 1st Faculty of Medicine, Charles University and General University Hospital in Prague"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Svobodova","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 1st Faculty of Medicine, Charles University and General University Hospital in Prague"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Jurisinova","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 1st Faculty of Medicine, Charles University and General University Hospital in Prague"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Maly","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 1st Faculty of Medicine, Charles University and General University Hospital in Prague"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Brozek","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 1st Faculty of Medicine, Charles University and General University Hospital in Prague"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Rulisek","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 1st Faculty of Medicine, Charles University and General University Hospital in Prague"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Trachta","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 1st Faculty of Medicine, Charles University and General University Hospital in Prague"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Tencer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital in Prague , Czechia, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Krajcova","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital in Prague , Czechia, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Duska","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 3rd Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital in Prague , Czechia, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1864-2143","authenticated-orcid":false,"given":"M","family":"Balik","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, 1st Faculty of Medicine, Charles University and General University Hospital in Prague"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,19]]},"container-title":["European Heart Journal: Acute Cardiovascular Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjacc\/advance-article-pdf\/doi\/10.1093\/ehjacc\/zuae023\/56705387\/zuae023.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjacc\/advance-article-pdf\/doi\/10.1093\/ehjacc\/zuae023\/56705387\/zuae023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T09:32:12Z","timestamp":1708335132000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjacc\/advance-article\/doi\/10.1093\/ehjacc\/zuae023\/7610476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ehjacc\/zuae023","relation":{},"ISSN":["2048-8726","2048-8734"],"issn-type":[{"value":"2048-8726","type":"print"},{"value":"2048-8734","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]},"article-number":"zuae023"}}