{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:16:23Z","timestamp":1789150583859,"version":"build-2803163510"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Despite increased temporary mechanical circulatory support (tMCS) utilization for acute myocardial infarction complicated by cardiogenic shock (AMI-CS), data regarding efficacy and optimal timing for tMCS support are limited. This study aimed to describe outcomes based on tMCS timing in AMI-CS and to identify predictors of 30-day mortality and readmission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Patients with AMI-CS identified in the National Readmissions Database were grouped according to the use of tMCS and early (&amp;lt;24\u2005h) vs. delayed (\u226524\u2005h) tMCS. The correlation between tMCS timing and inpatient outcomes was evaluated using linear regression. Multivariate logistic regression was used to identify variables associated with 30-day mortality and readmission. Of 294 839 patients with AMI-CS, 109 148 patients were supported with tMCS (8067 veno-arterial extracorporeal membrane oxygenation, 33 577 Impella, and 79 161 intra-aortic balloon pump). Of patients requiring tMCS, patients who received early tMCS (n = 79 906) had shorter lengths of stay (7 vs. 15 days, P &amp;lt; 0.001) and lower rates of ischaemic and bleeding complications than those with delayed tMCS (n = 32 241). Patients requiring tMCS had higher in-hospital mortality [odds ratio (95% confidence interval)] [1.7 (1.7\u20131.8), P &amp;lt; 0.001]. Among patients requiring tMCS, early support was associated with fewer complications, lower mortality [0.90 (0.85\u20130.94), P &amp;lt; 0.001], and fewer 30-day readmissions [0.91 (0.85\u20130.97), P = 0.005] compared with patients with delayed tMCS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Among patients receiving tMCS for AMI-CS, early tMCS was associated with fewer complications, shorter lengths of stay, lower hospital costs, and fewer deaths and readmissions at 30 days.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuae034","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T19:58:01Z","timestamp":1710878281000},"page":"390-397","source":"Crossref","is-referenced-by-count":13,"title":["Early vs. delayed mechanical circulatory support in patients with acute myocardial infarction and cardiogenic shock"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3465-5681","authenticated-orcid":false,"given":"Kevin G","family":"Buda","sequence":"first","affiliation":[{"name":"Allina Health\u2014Minneapolis Heart Institute , 800 E 28th St, Heart Hospital, Minneapolis, MN 55407 , USA"},{"name":"Cardiology Division, Department of Internal Medicine, Hennepin Healthcare , 730 S. 8th St, Minneapolis, MN 55415 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Hryniewicz","sequence":"additional","affiliation":[{"name":"Allina Health\u2014Minneapolis Heart Institute , 800 E 28th St, Heart Hospital, Minneapolis, MN 55407 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M","family":"Eckman","sequence":"additional","affiliation":[{"name":"Allina Health\u2014Minneapolis Heart Institute , 800 E 28th St, Heart Hospital, Minneapolis, MN 55407 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir B","family":"Basir","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Henry Ford Hospital , 2799 W Grand Blvd, Detroit, MI 48208 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Cowger","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Henry Ford Hospital , 2799 W Grand Blvd, Detroit, MI 48208 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaldoon","family":"Alaswad","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Henry Ford Hospital , 2799 W Grand Blvd, Detroit, MI 48208 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srini","family":"Mukundan","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute, Oregon Health and Science University , 3303 S Bond Ave, Building 1, 7th Floor, Portland, OR 97239 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yader","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Allina Health\u2014Minneapolis Heart Institute , 800 E 28th St, Heart Hospital, Minneapolis, MN 55407 , USA"},{"name":"Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation , 920 East 28th Street, Suite 100, Minneapolis, MN 55407 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Elliott","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Minnesota , 401 E River Pkwy, Minneapolis, MN 55455 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil S","family":"Brilakis","sequence":"additional","affiliation":[{"name":"Allina Health\u2014Minneapolis Heart Institute , 800 E 28th St, Heart Hospital, Minneapolis, MN 55407 , USA"},{"name":"Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation , 920 East 28th Street, Suite 100, Minneapolis, MN 55407 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S","family":"Megaly","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Willis Knighton Heart Institute , 2400 Hospital Drive #350, Shreveport, LA 71111 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"2024052816272882500_zuae034-B1","first-page":"341","article-title":"Temporal trends and outcomes of patients undergoing percutaneous coronary interventions for cardiogenic shock in the setting of acute myocardial infarction: a report from the CathPCI Registry","volume":"9","author":"Wayangankar","year":"2016","journal-title":"Cardiovasc Interv"},{"key":"2024052816272882500_zuae034-B2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jacasi.2022.10.004","article-title":"Prognosis in patients with cardiogenic shock who received temporary 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