{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:43:24Z","timestamp":1740167004374,"version":"3.37.3"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Korean Society of Interventional Cardiology","award":["2016-1"],"award-info":[{"award-number":["2016-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Although culprit-only revascularization during the index procedure has been recommended in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS), the reduction in residual ischaemia is also emphasized to improve clinical outcomes. However, few data are available about the significance of residual ischaemia in patients undergoing mechanical circulatory supports. This study aimed to evaluate the effects of residual ischaemia on clinical outcomes in patients with AMI undergoing venoarterial\u2013extracorporeal membrane oxygenation (VA-ECMO).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Patients with AMI with multivessel disease who underwent VA-ECMO due to refractory CS were pooled from the RESCUE and SMC-ECMO registries. The included patients were classified into three groups according to residual ischaemia evaluated using the residual Synergy between percutaneous coronary intervention with Taxus and Cardiac Surgery (SYNTAX) score (rSS): rSS = 0, 0 &amp;lt; rSS \u2264 8, and rSS &amp;gt; 8. The primary outcome was 1-year all-cause death. A total of 408 patients were classified into the rSS = 0 (n = 100, 24.5%), 0 &amp;lt; rSS \u2264 8 (n = 136, 33.3%), and rSS &amp;gt; 8 (n = 172, 42.2%) groups. The cumulative incidence of the primary outcome differed significantly according to rSS (33.9 vs. 55.4 vs. 66.1% for rSS = 0, 0 &amp;lt; rSS \u2264 8, and rSS &amp;gt; 8, respectively, overall P &amp;lt; 0.001). In a multivariable model, rSS was independently associated with the risk of 1-year all-cause death (adjusted hazard ratio 1.03, 95% confidence interval 1.01\u20131.05, P = 0.003). Conversely, the baseline SYNTAX score was not associated with the risk of the primary outcome. Furthermore, when patients were stratified by rSS, the primary outcome did not differ significantly between the high and low delta SYNTAX score groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with AMI with refractory CS who underwent VA-ECMO, residual ischaemia was associated with an increased risk of 1-year mortality. Future studies are needed to evaluate the efficacy and safety of revascularization strategies to minimize residual ischaemia in patients with CS supported with VA-ECMO.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trial registration<\/jats:title>\n                  <jats:p>REtrospective and Prospective Observational Study to Investigate Clinical oUtcomes and Efficacy of Left Ventricular Assist Device for Korean Patients With Cardiogenic Shock (RESCUE), NCT02985008.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuae058","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T17:51:18Z","timestamp":1714758678000},"page":"525-534","source":"Crossref","is-referenced-by-count":3,"title":["Clinical significance of residual ischaemia in acute myocardial infarction complicated by cardiogenic shock undergoing venoarterial\u2013extracorporeal membrane oxygenation"],"prefix":"10.1093","volume":"13","author":[{"given":"David","family":"Hong","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-ro, Gangnam-gu, Seoul 06351 , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Hong","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-ro, Gangnam-gu, Seoul 06351 , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul-Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine , Seoul , South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol Woong","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital , Seoul , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ik Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine , Changwon , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Jin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ewha Woman\u2019s University Seoul Hospital, Ewha Woman\u2019s University School of Medicine , Seoul , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Konkuk University Medical Center, School of Medicine, Konkuk University , Seoul , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang-Whan","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chungbuk National University College of Medicine , Cheongju , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Uk","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Ilsan Paik Hospital, University of Inje College of Medicine , Seoul , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Jong","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Sejong General Hospital , Bucheon , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Chung-Ang University Hospital , Seoul , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Ok","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Chungnam National University Hospital , Daejeon , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Don","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Inha University Hospital , Incheon , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taek Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-ro, Gangnam-gu, Seoul 06351 , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2178-4014","authenticated-orcid":false,"given":"Joo Myung","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-ro, Gangnam-gu, Seoul 06351 , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3986-9152","authenticated-orcid":false,"given":"Young Bin","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-ro, Gangnam-gu, Seoul 06351 , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo-Yong","family":"Hahn","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81 Irwon-ro, Gangnam-gu, Seoul 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