{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:35:38Z","timestamp":1785285338308,"version":"3.55.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung and Blood Institute","doi-asserted-by":"publisher","award":["T32HL007604"],"award-info":[{"award-number":["T32HL007604"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Eugene Braunwald Cardiovascular Physician Scientist Junior Faculty"},{"name":"Heart and Vascular Center Faculty"},{"DOI":"10.13039\/100005292","name":"Brigham and Women\u2019s Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005292","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals, Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We sought to characterize circulating protein biomarkers associated with cardiogenic shock (CS) using highly multiplex proteomic profiling.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This analysis employed a cross-sectional case\u2013control study design using a biorepository of patients admitted to a cardiac intensive care unit between 2017 and 2020. Cases were patients adjudicated to have CS, and controls were those presenting for cardiac critical care without shock, including subsets of patients with isolated hypotension or heart failure (HF). The Olink platform was used to analyse 359 biomarkers with Bonferroni correction. The analysis included 239 patients presenting for cardiac critical care (69 cases with CS, 170 non-shock controls). A total of 63 biomarkers (17.7%) were significantly associated with CS after Bonferroni correction compared with all controls. Of these, nine biomarkers remained significantly associated with CS when separately cross-validated in subsets of controls presenting with isolated hypotension and HF: cathepsin D, fibroblast growth factor (FGF)-21 and -23, growth differentiation factor (GDF)-15, insulin-like growth factor-binding protein-1, N-terminal pro-B-type natriuretic peptide, osteopontin, oncostatin-M-specific receptor subunit beta (OSMR), and soluble ST2 protein (sST2). Four biomarkers were identified as providing complementary information for CS diagnosis with development of a multi-marker model: sST2, FGF-23, CTSD, and GDF-15.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In this pilot study of targeted proteomic profiling in CS, we identified nine biomarkers significantly associated with CS when cross-validated against non-shock controls including those with HF or isolated hypotension, illustrating the potential application of a targeted proteomic approach to identify novel candidates that may support the diagnosis of CS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuae068","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T20:48:46Z","timestamp":1717015726000},"page":"624-628","source":"Crossref","is-referenced-by-count":6,"title":["Targeted proteomic profiling of cardiogenic shock in the cardiac intensive care unit"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4637-4361","authenticated-orcid":false,"given":"Siddharth M","family":"Patel","sequence":"first","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 75 Francis St., Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew S","family":"Lopes","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 75 Francis St., Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Morrow","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 75 Francis St., Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bellavia","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 75 Francis St., Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankeet S","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kaiser Permanente San Francisco Medical Center and Division of Research , San Francisco, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayleigh K","family":"Butler","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 75 Francis St., Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"D\u2019Antonio","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc. , Tarrytown, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dunn","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc. , Tarrytown, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Antonio A","family":"Fagundes","sequence":"additional","affiliation":[{"name":"IDOR, D\u2019Or Institute for Research and Education, DFStar Hospital , Bras\u00edlia, DF ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9612-8652","authenticated-orcid":false,"given":"Petr","family":"Jarolim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan P","family":"Marin","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc. , Tarrytown, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Morton","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc. , Tarrytown, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A","family":"Olenchock","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc. , Tarrytown, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balimkiz","family":"Senman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Duke University School of Medicine , Durham, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danuzia S","family":"da Silva","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical School , Minneapolis, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anubodh S","family":"Varshney","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Stanford University , Palo Alto, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin A","family":"Bohula","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 75 Francis St., Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-5492","authenticated-orcid":false,"given":"David 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registry","volume":"27","author":"Bhatt","year":"2021","journal-title":"J Card Fail"},{"key":"2025030516281464500_zuae068-B3","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1161\/CIR.0000000000000525","article-title":"Contemporary management of cardiogenic shock: a scientific statement from the American Heart Association","volume":"136","author":"van Diepen","year":"2017","journal-title":"Circulation"},{"key":"2025030516281464500_zuae068-B4","doi-asserted-by":"crossref","first-page":"e009714","DOI":"10.1161\/CIRCHEARTFAILURE.122.009714","article-title":"Clinician and algorithmic application of the 2019 and 2022 Society of Cardiovascular Angiography and Intervention Shock Stages in the Critical Care Cardiology Trials Network registry","volume":"16","author":"Patel","year":"2023","journal-title":"Circ Heart Fail"},{"key":"2025030516281464500_zuae068-B5","first-page":"1","article-title":"Advances in the staging and phenotyping of cardiogenic shock","volume":"1","author":"Jentzer","year":"2022","journal-title":"JACC: Advances"},{"key":"2025030516281464500_zuae068-B6","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1093\/eurheartj\/ehz294","article-title":"Protein-based cardiogenic shock patient classifier","volume":"40","author":"Rueda","year":"2019","journal-title":"Eur Heart J"},{"key":"2025030516281464500_zuae068-B7","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/ejhf.117","article-title":"Growth-differentiation factor 15 and osteoprotegerin in acute myocardial infarction complicated by cardiogenic shock: a biomarker substudy of the IABP-SHOCK II-trial","volume":"16","author":"Fuernau","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"2025030516281464500_zuae068-B8","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1093\/eurheartj\/ehz783","article-title":"Molecular signature of cardiogenic shock","volume":"41","author":"Iborra-Egea","year":"2020","journal-title":"Eur Heart J"}],"container-title":["European Heart Journal: Acute Cardiovascular 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