{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:22Z","timestamp":1792785862312,"version":"4.5.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH-NHLBI","award":["K08HL163328"],"award-info":[{"award-number":["K08HL163328"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The Shock Academic Research Consortium (SHARC) recently proposed pragmatic consensus definitions to standardize classification of cardiogenic shock (CS) in registries and clinical trials. We aimed to describe contemporary CS epidemiology using the SHARC definitions in a cardiac intensive care unit (CICU) population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The Critical Care Cardiology Trials Network (CCCTN) is a multinational research network of advanced CICUs coordinated by the TIMI Study Group (Boston, MA). Cardiogenic shock was defined as a cardiac disorder resulting in SBP &amp;lt; 90\u2005mmHg for \u226530\u2005min [or the need for vasopressors, inotropes, or mechanical circulatory support (MCS) to maintain SBP \u2265 90\u2005mmHg] with evidence of hypoperfusion. Primary aetiologic categories included acute myocardial infarction-related CS (AMI-CS), heart failure-related CS (HF-CS), and non-myocardial (secondary) CS. Post-cardiotomy CS was not included. Heart failure-related CS was further subcategorized as de novo vs. acute-on-chronic HF-CS. Patients with both cardiogenic and non-cardiogenic components of shock were classified separately as mixed CS. Of 8974 patients meeting shock criteria (2017\u201323), 65% had isolated CS and 17% had mixed shock. Among patients with CS (n = 5869), 27% had AMI-CS (65% STEMI), 59% HF-CS (72% acute-on-chronic, 28% de novo), and 14% secondary CS. Patients with AMI-CS and de novo HF-CS were most likely to have had concomitant cardiac arrest (P &amp;lt; 0.001). Patients with AMI-CS and mixed CS were most likely to present in more severe shock stages (SCAI D or E; P &amp;lt; 0.001). Temporary MCS use was highest in AMI-CS (59%). In-hospital mortality was highest in mixed CS (48%), followed by AMI-CS (41%), similar in de novo HF-CS (31%) and secondary CS (31%), and lowest in acute-on-chronic HF-CS (25%; P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SHARC consensus definitions for CS classification can be pragmatically applied in contemporary registries and reveal discrete subpopulations of CS with distinct phenotypes and outcomes that may be relevant to clinical practice and future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuae098","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T18:11:33Z","timestamp":1724955093000},"page":"709-714","source":"Crossref","is-referenced-by-count":29,"title":["Epidemiology of cardiogenic shock using the Shock Academic Research Consortium (SHARC) consensus definitions"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-5492","authenticated-orcid":false,"given":"David D","family":"Berg","sequence":"first","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 60 Fenwood Road, Suite 7022, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin A","family":"Bohula","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 60 Fenwood Road, Suite 7022, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth M","family":"Patel","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 60 Fenwood Road, Suite 7022, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Miami Hospital, University of Miami Miller School of Medicine , Miami, FL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos L","family":"Alviar","sequence":"additional","affiliation":[{"name":"Leon H Charney Division of Cardiology, New York University Grossman School of Medicine , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian M","family":"Baird-Zars","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 60 Fenwood Road, Suite 7022, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher F","family":"Barnett","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of California San Francisco , San Francisco, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W","family":"Barsness","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney E","family":"Bennett","sequence":"additional","affiliation":[{"name":"Lehigh Valley Heart Institute , Department of Cardiology, Allentown, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunit-Preet","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Vincent Heart Center , Indianapolis, IN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B","family":"Fordyce","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Vancouver General Hospital and The Centre for Cardiovascular Innovation, University of British Columbia , Vancouver, BC ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahab","family":"Ghafghazi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Louisville School of Medicine , Louisville, KY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh K","family":"Gidwani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Goldfarb","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Jewish General Hospital, McGill University , Montreal, QC ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason N","family":"Katz","sequence":"additional","affiliation":[{"name":"Leon H Charney Division of Cardiology, New York University Grossman School of Medicine , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4410-2677","authenticated-orcid":false,"given":"Venu","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Heart and Vascular Institute , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Elliott","family":"Miller","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale University , New Haven, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Kristin","family":"Newby","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine and Duke Clinical Research Institute, Duke University , Durham, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander I","family":"Papolos","sequence":"additional","affiliation":[{"name":"Departments of Cardiology and Critical Care, MedStar Washington Hospital Center , Washington, DC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4615-1747","authenticated-orcid":false,"given":"Jeong-Gun","family":"Park","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 60 Fenwood Road, Suite 7022, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Pierce","sequence":"additional","affiliation":[{"name":"Northwell Cardiovascular Institute , New Hyde Park, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair G","family":"Proudfoot","sequence":"additional","affiliation":[{"name":"Department of Perioperative Medicine, Barts Heart Centre, Barts Health NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank S","family":"Sinha","sequence":"additional","affiliation":[{"name":"Inova Schar Heart and Vascular, Inova Fairfax Medical Campus , Falls Church, VA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Sridharan","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Emory University School of Medicine , Atlanta, GA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea D","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Michigan , Ann Arbor, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-828X","authenticated-orcid":false,"given":"Sean","family":"van Diepen","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine and Division of Cardiology, Department of Medicine, University of Alberta , Edmonton, AB ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Morrow","sequence":"additional","affiliation":[{"name":"Levine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , 60 Fenwood Road, Suite 7022, Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"2024102905273044800_zuae098-B1","doi-asserted-by":"crossref","first-page":"e005618","DOI":"10.1161\/CIRCOUTCOMES.119.005618","article-title":"Epidemiology of shock in contemporary cardiac intensive care units","volume":"12","author":"Berg","year":"2019","journal-title":"Circ Cardiovasc Qual 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