{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T13:24:12Z","timestamp":1763990652441,"version":"3.45.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R01HL168040-01"],"award-info":[{"award-number":["1R01HL168040-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022183","name":"Danish Society of Anaesthesiology and Intensive Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022183","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","award":["L-2022-00176"],"award-info":[{"award-number":["L-2022-00176"]}],"id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006308","name":"Helga og Peter Kornings Fond","doi-asserted-by":"publisher","award":["DC472123- 007-30"],"award-info":[{"award-number":["DC472123- 007-30"]}],"id":[{"id":"10.13039\/501100006308","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009918","name":"Oda og Hans Svenningsens fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009918","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004331","name":"Snedkermester Jacobsen og hustru Astrid Jacobsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004046","name":"Karen Elise Jensens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Acute intermediate-high-risk pulmonary embolism (PE) causes a pathological increase in pulmonary artery pressure and right ventricle afterload that may progress to right ventricle failure and cardiopulmonary collapse. Patients may require mechanical ventilation, further increasing pulmonary vascular resistance (PVR) and artery pressure. We aimed to investigate the ability of ventilator settings adjustments to reduce pulmonary artery pressure in a porcine model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Eleven Danish female pigs (Landrace\/Yorkshire\/Duroc) of \u224860\u2005kg were used to perform a randomized, blinded, cross-over, experimental study. Following induction of acute PE, the animals were subject to four randomized interventions with wash-out periods in between: (1) changes in positive end-expiratory pressure (PEEP) (from 5 to 0, 10 and 15 cmH2O), (2) 50 and 100% increase in minute ventilation (hypocapnia), (3) increase in fraction of inspired oxygen (FiO2, from 21 to 40%), and (4) infusion of sodium bicarbonate to induce alkalosis. The main outcome was mean pulmonary artery pressure (mPAP). mPAP was reduced by a reduction in PEEP (28 \u00b1 6 vs. 26 \u00b1 5\u2005mmHg, P = 0.011), hypocapnia (27 \u00b1 6 vs. 23 \u00b1 5\u2005mmHg, P = 0.0004), alkalosis (27 \u00b1 4 vs. 25 \u00b1 5\u2005mmHg, P = 0.003), and increased fraction of inspired oxygen (28 \u00b1 6 vs. 23 \u00b1 5\u2005mmHg, P &amp;lt; 0.0001). Changes in PVR showed similar patterns (P &amp;lt; 0.05 for all).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a porcine model of acute PE reduction of PEEP, permissive hypocapnia through hyperventilation, alkalosis, and increased fraction of inspired oxygen can reduce mPAP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjacc\/zuaf036","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T16:32:07Z","timestamp":1741105927000},"page":"455-462","source":"Crossref","is-referenced-by-count":1,"title":["Mechanical ventilation in acute pulmonary embolism: a randomized, experimental, crossover study"],"prefix":"10.1093","volume":"14","author":[{"given":"Cecilie Dahl","family":"Baltsen","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Aarhus University Hospital , Palle Juul Jensens Boulevard 99, 8200 Aarhus N ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Aarhus University , 8200 Aarhus N ,","place":["Denmark"]},{"name":"Department of Emergency Medicine, Center for Vascular Emergencies, Massachusetts General Hospital , 125 Nashua Street, Suite 460, Boston, 02114 MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark Stoltenberg","family":"Ellegaard","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Aarhus University Hospital , Palle Juul Jensens Boulevard 99, 8200 Aarhus N ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Aarhus University , 8200 Aarhus N ,","place":["Denmark"]},{"name":"Department of Emergency Medicine, Center for Vascular Emergencies, Massachusetts General Hospital , 125 Nashua Street, Suite 460, Boston, 02114 MA, 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,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8699-7176","authenticated-orcid":false,"given":"Christopher","family":"Kabrhel","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Center for Vascular Emergencies, Massachusetts General Hospital , 125 Nashua Street, Suite 460, Boston, 02114 MA, USA"},{"name":"Department of Emergency Medicine, Harvard Medical School , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9102-3130","authenticated-orcid":false,"given":"Asger","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University , 8200 Aarhus N ,","place":["Denmark"]},{"name":"Department of Cardiology, Aarhus University Hospital , 8200 Aarhus N 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